Questions tagged [medicine]

Medicine is the doctrine of prevention, diagnosis and treatment of diseases and injuries in humans and animals. Health and medicine questions are off-topic unless dealing with the biology underlying health and medicine. Please carefully explore the tour, help centre, and meta before posting health and medicine questions.

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Monoclonal antibody mass production

There is a long conversation taking place these days about monoclonal antibodies against COVID-19. From a few biology courses I had a long time ago, I remember that the process of creating mAbs was a ...
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Can a man produce higher levels of estrogen than a woman if he has Aromatase Excess Syndrome?

I was reading about Aromatase Excess Syndrome and I found out that a man can produce large amounts of estrogen if they have this condition but I want to know if he could produce more estrogen than a ...
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Why is syphilis not resistant to penicilin?

How is it that we are dealing with so many antiobiotic resistant infections in iatrogenic settings, and yet this very old bacterial pathogen has still not acquired resistance to penicilin (the oldest ...
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Why exactly does UMN lesion cause hypertonia?

The corticospinal tracts are excitatory in nature (Glutaminergic). So damage of the CST would mean less excitatory input to the LMN. By this logic, there should not be hypertonia. What is the ...
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Why is heparin contraindicated in patients with severe uncontrolled hypertension?

Heparin is a parenteral anti coagulant- prevents clot formation by inhibiting factors 2 a and 10 a mainly. Now, patients with severe uncontrolled hypertension- have persistent bp of more than 140/90. ...
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Ingredients in Pfizer vaccine

The ingredients in the Pfizer vaccine have been listed in a number of websites, including government healthcare ones. This site claims that the list includes ALL of the ingredients of the vaccine. ...
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Safety in Liposomal Amphotericin B

From reading about Amphotericin B antifungal, I understand it is quite a toxic medicine for kidney, but I am not able to find any details as to how Liposomal version of same medication is so safe, in ...
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Is P-Glycoprotein (or lack thereof) associated with sulfa drug sensitivity / allergy?

A deficiency in membrane P-Glycoprotein is known to cause toxic effects in some organ systems due to the increased bio-availability of drugs that are transported by P-Gp. Has it been shown that sulfa-...
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How does the immune system fight scabies mites?

After a distressing episode involving my elderly mother and a nursing home, I've been reading up on scabies. It seems that in healthy people, the immune system limits the mite population to around 10 ...
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124 views

Concentration of active ingredient

For some time now, I have been wondering why, when a tablet is taken, the concentration of active ingredient undergoes an exponential decrease after the maximum concentration value in the blood is ...
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Why does warfarin decrease biological activity of protein C?

Warfarin inhibits VKOR. Hence it disrupts vitamin K dependent $\gamma$-carboxylation of Fc- II, VII, IX, X. But what exactly it does to Protein C and Protein S? How does it also affect anticoagulant ...
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Pathophysiology of pink frothy sputum in pulmonary edema

Pulmonary edema is a condition where fluid leaks into the alveolar spaces. This can be due to to hemodynamic causes like left heart failure and pulmonary venous obstruction or microvascular injury or ...
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How do APCs find their specific T-cells in the lymph nodes?

My understanding is that when an APC (more specifically a dendritic cell) encounters an antigen in the periphery, it ingests it and presents it on its surface. It then migrates to lymph nodes to ...
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What exactly makes red meat (probably) unhealthy?

It seems generally agreed that (even fresh, unprocessed) red meat is at least somewhat bad for human health. But why exactly is this the case? It's difficult to find any attempt at an explanation, ...
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How do physics notions of fluid dynamics relate to pressure gradients in circulation?

I'm having a hard time comprehending why sometimes physiology notions seem to contradict each other and contradict physics teachings. More specifically I don't understand why aortic coarctation causes ...
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What are the coverings of femoral hernia?

It was my Viva question and I was really puzzled.I know what is femoral hernia and it route like the abdominal content moves down the femoral canal and further through the saphenous opening and all ...
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Why is the IC50 an interesting measure for in vitro cancer drug screenings?

Large-scale in vitro screenings of (potential) cancer drugs are done to access their effectivity depending on the actual transcriptome of a tumor cell line. Databases like GDSC or CCLE supply data of ...
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Is Valerian extract a diuretic or an antidiuretic?

I am trying to determine if valepotriates (valerian extract) is a diuretic or an antidiuretic. Some individuals take valerian as an herbal supplement for anxiety disorders. Some individuals claim that ...
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Are there any medical treatments which no longer work because humans have evolved?

(Not sure if this should be on the medicine SE) There've been plenty of medicines that no longer work because the target pathogen has evolved resistance, e.g. penicillin is no longer an effective ...
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Why do beta-1 and beta-2 adrenergic receptors result in two completely different effects (though both use Gs pathway)?

$\beta_2$ adrenergic Receptors are $G_s$-coupled 7-TM proteins. Considering that $G_s$ , by activation increases $[\text{cAMP}]_\text{cytosol}$ which inhibits MLCK of smooth muscles (and causes ...
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150 views

Why is Ibuprofen contraindicated in asthma patients?

So yesterday a patient showed up at the clinic with a massive swelling in his left face region. Upon examination it was found to be due to infected first premolar. Dentist recommended him to get the ...
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Does Topiramate work by supplanting Pyridoxal phosphate in enzymes?

I have seen it said that the precise mechanism of action of migraine medicine Topiramate is not known. But I certainly see a resemblance between that molecule and PLP (Pyridoxal phosphate, the ...
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Why is half dose of Oxford's vaccine of covid more effective than full dose?

I recently read in a newspaper that the half dose of the Oxford's vaccine is 90% effective while the full dose is only 62% effective. Why is this the case ?
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What are the physiological effects of retinal exposure to 380–400nm light?

There are two categories of sunglasses: UV380 sunglasses block all light with wavelength 380nm or lower, while UV400 sunglasses block all light with wavelength 400nm or lower. This made me wonder, ...
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The relation of a schizophrenia drug side effect and caffeine intake

I am listening to the book Surviving Schizophrenia and in the book, it is mentioned that drugs like Clozapine increases in blood level if the patient takes Caffeine, and can have side effects due to ...
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Why is the current flow shown to be flowing from the negative area towards the positive area?

When I was studying the ECG chapter in the book "Guyton and Hall Textbook of Medical Physiology", I noticed something odd in one of the pictures: As you can see the current is shown to be ...
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What is the mechanism of aspirin as an anticoagulant? [duplicate]

I understand that aspirin prevents blood clots from forming by interfering with the clotting action. I want to know at which stage aspirin interferes with clot forming and what really happens in the ...
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How does a Coronavirus "test kit" work?

A number of countries are using test kits for detecting new cases of nCoV (2019-Coronavirus) and apparently China is running low. What exactly is in a nCoV "Test Kit" — How does it work? (Surely ...
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Are there any real life instances of kidney organoid transplants in human?

Googling the terms "kidney organoid", "artificial kidney" etc. shows quite a huge amount of research papers regarding studies about kidney organoid synthesis from pluripotent stem ...
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Difference between dysentery and bloody diarrhea

The difference between diarrhoea and dysentery is quite clear; but the appearance of blood in stool or bloody diarrhoea is a very confusing term when compared with dysentery. Are they different in the ...
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1answer
52 views

Why is prothrombin time used to monitor warfarin and not activated partial thromboplastin time?

Warfarin is said to change prothrombin time (PT) but not activated partial thromboplastin time (aPTT) (for practical purposes at least anyways, not really sure). But looking at the mechanism of action ...
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1answer
47 views

How does the age of a parent affect the chances of occurrence of certain genetically transmitted diseases?

Do genetically transmitted age-related diseases (like hypertension, arthritis etc.)have the probability of occurring at an earlier(younger) age in the offspring if they are born at a later age to ...
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About how many covid-19 virus particles is required in the human body before infection and sickness follows?

Our immune systems are often able to destroy germs and virus particles. About how many of them does it take to make a 70 year old healthy male sick ? Any ideas ?
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Would intravenous insulin + glucose significantly accelerate glycogen synthesis?

Would an intravenous injection of insulin + glucose result in significantly quicker replenishment of exhausted glycogen stores than an injection of glucose alone? This is a strictly theoretical ...
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Why is there no herd immunity against common cold coronaviruses?

In discussions of herd immunity against SARS-CoV-2 the underlying assumption usually appears to be that the virus basically stops spreading once a sufficient percentage of the population has overcome ...
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116 views

How do painkillers prevent shock?

I was reading about the Placebo effect and came across this little story: The roots of the placebo problem can be traced to a lie told by an Army nurse during World War II as Allied forces ...
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What are some good books on oncology?

I'm looking for some book suggestions on oncology, preferably I want them to be fairly recent. I am not worried if they are fairly technical, as long as they have good accurate content and layout.
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What causes rashes to appear in specific parts of the body without a site specific trigger?

Why do rashes appear randomly at highly specific locations (and not others), without location specific triggers? Like, if it's a systemic issue, then it should be distributed to other areas on the ...
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Alzheimer's disease - Hyperexcitability

I am trying to read literature on Alzheimer's disease. A very important phenomenon that occurs in AD patients, is hyperexcitability in neurons close to A-beta concentrations. Some authors only ...
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1answer
46 views

What fraction of human cells gets infected during a viral infection?

As I understand, if a cell gets infected during a viral infection then it eventually dies. If an individual does not die of an infection, the percentage of cells that gets infected in the course of ...
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327 views

Why do doctors still advise HIV+ couples to wear a condom during sex?

HIV infected people already have HIV, but why do doctors still advise condom use for HIV+ couples?
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Edema and hydrostatic pressure

I'm currently studying Robbins basic pathology, and I'm confused about a specific statement: It states in the book that when hydrostatic pressure is low due to a lack of albumin synthesis, it leads ...
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How does the surface of the eye remain moist during sleep?

When we are awake, blinking helps distribute the tears so the cornea and the entire conjunctiva are wet and moist. But how is this maintained during the night, when we are sleep and there is no ...
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258 views

Is it possible to synthesize chiral version of an organism (incompatible with our pathogens)?

In theory, it should be possible to synthesize chiral (mirror image) version of some organism: with all molecules replaced with their enantiomers, e.g. L-sugars in place of our D-sugars. Direct ...
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72 views

How far can free radicals from UV radiation diffuse through the skin?

UV radiation damages DNA through two separate mechanisms. Direct damage occurs when a photon is absorbed by DNA. Indirect damage occurs when a photon is absorbed by a chromophore, and the excited ...
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Can far-UVC light be safely used as germicide? (help understanding a paper)

I've been trying to familiarize myself with the literature on far UVC light as a germicide. My question mostly pertains to figure 4 of this paper. The paper investigates the efficacy of 207 nm light ...
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Can erythrocytes Function without plasma?

my title is not very specific. So i will proceed to clarify it. I am trying to make sure that the only blood cells in a sample are Erytocytes, since i want to evaluate their metabolism, I am aware ...
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Inability of vultures to digest diclofenac

The population of Indian vultures has been rapidly declining since 2003. This is attributed to the diclofenac present in the carcasses which the vultures eat. Vultures seem to digest all sorts of food ...
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Why is insulin given in type 2 diabetes?

For this reason "insulin insensitivity", or a decrease in insulin receptor signaling, leads to diabetes mellitus type 2 – the cells are unable to take up glucose, and the result is hyperglycemia (an ...
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WHO Essential Medicines vs Essential Medicines for Children

Per the WHO (World Health Organization), there are a list of "Essential Medicines" such as those listed on their Wikipedia page. Is there a database link for this directly other than Wikipedia? What ...

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