Questions tagged [metabolism]

Metabolism is the set of defined biochemical transformations occurring within the cells of living organisms.

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14k views

What is/are the molecular differences between HDL and LDL cholesterol?

Why exactly is HDL-cholesterol good for us and LDL-cholesterol bad for us. It has been well-established that LDL-cholesterol is associated with atherosclerosis and that HDL-cholesterol helps remove ...
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What is a coupled reaction and why do cells couple reactions?

I was wondering what exactly a coupled reaction is and why cells couple them. I read the wikipedia article as well as several others, such as life.illinois.edu but I still don't get it. Could ...
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Are carbohydrates an essential component of human diet?

Are people able to satisfy all the needs of a healthy diet without consuming carbohydrates? My question includes the assumption that a person has no health condition that would prevent them from ...
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Why are there so many medicinal plants?

Question Quite a few plant species can be used for medicinal purposes wiki. As an example, Filipendula ulmaria is rich in acetylsalicylic acid (aspirin). An allele that produces a substance which is ...
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Why is the brain dependent on glucose?

The strict dependence of the (human) brain on glucose has always been puzzling to me. While ketones can substitute for a portion of the brain's energy needs, it cannot substitute completely: blood ...
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During starvation, does the human body do anything to prioritize which organs receive nutrients?

When food is scarce, the body slows its metabolic rate to conserve energy. Are there any other systems or processes that prioritize which organs receive nutrients?
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In humans what is the last metabolic process to cease after death?

After death which of our body's metabolic processes will continue functioning for the longest?
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How can haired mammals synthesize vitamin D?

The human body can synthesize vitamin D in the skin from cholesterol, when sun exposure is adequate. But how can haired mammals do it? Do not they need it?
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How much energy does a small spider expend per day just waiting for its web to vibrate?

Roughly speaking, a small, complex electronic circuit or IC might sit in "sleep mode" using a current of roughly 1 µA (e.g. 1, 2), thereby using roughly $3\times 10^{-6}$ Watts, and that ...
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Statistical method for characterizing the relationship between body mass and metabolic rate

There is a dataset that contains body mass ($x$) and metabolic rate ($y$) from many different organisms. It is common to fit the data to the model of the form $y=ax^b$ and estimate the parameters $a$ ...
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Why only 6 water molecules are formed in the aerobic degradation of glucose?

I am studying the aerobic degradation of glucose and it seems that for every glucose molecule we should obtain $\ce{10H2O}$ molecules. However, it is known that we only obtain 6. $\ce{C6H12O6 + 6O2 -&...
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What is the source of the electrons generated in the Krebs cycle?

In the Krebs cycle, where do the hydrogens and electrons that NAD+ and FAD accept come from? It seems that citric acid only loses two hydrogens because it starts out with eight hydrogens and then ...
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What is the purpose of gluconeogenesis?

The gluconeogenesis pathway seems quite pointless to me. I don't understand why an organism would want to spend energy to create a molecule that can then be metabolized again for less energy? The ...
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Is palmitic acid really that dangerous?

According to Wikipedia, "Palmitic acid is the most common saturated fatty acid found in animals, plants and microorganisms. It is also the first fatty acid produced during fatty acid synthesis and is ...
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What is the molecular basis of hangovers?

Well, most of us have experienced the wonderful feeling of the dreaded hangover. How does it work exactly? I imagine it has something to do with dehydration but what are the underlying mechanisms? ...
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Why is a magnesium ion essential for ATP activity in enzymic reactions?

The Wikipedia entry on Magnesium in Biology includes the following: ATP (adenosine triphosphate), the main source of energy in cells, must be bound to a magnesium ion in order to be biologically ...
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Is it wrong to consider an allosteric inhibitor a non-competitive inhibitor?

Supose Caspase-1 is allosterically inhibited. Since the inhibitor is not binding in the active site but instead in the allosteric binding site, can I conclude it is a non-competitive inhibitor?
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Apparent paradox in Glucagon action

Glucagon stimulates glycogenolysis and gluconeogenesis, thus increasing the plasma glucose concentration — so that tissues get enough glucose in the fasting state. However glucagon also inhibits ...
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222 views

What is the energy consumption of the brain?

What is the energy consumption of the brain, and is there a difference in consumption when waking and sleeping?
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Does Glycolysis produce lactate, or pyruvate?

EDIT- Somebody suggested that this is the same question as this, it isn't. This one is asking about the definition of glycolysis. That one was asking about the definition of fermentation. Does ...
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What mechanisms tell temperate trees when to drop leaves?

I've been looking around and cannot find a definite answer on what it is that tells trees to change their metabolism and drop leaves. I see that such activity is called Deciduous. What interests me ...
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Circulation through the liver in light of drug metabolism

I have a lingering question which stems from an answer that I gave to What hydrolyses aspirin within the digestive tract and blood stream? When a drug or any other substance is absorbed into the ...
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Do plants need O₂ to consume energy they've stored via sugar?

This question came up as I work my way through the answers to another question I just asked. My understanding is that plant photosynthesis looks something like this (though with lots more going on ...
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Do plants take in the same amount of CO2 as they release?

There are many claims in the media that trees remove more carbon dioxide form the atmosphere than they release back into the atmosphere. By what chemical pathway can this occur? The law that matter is ...
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Is there any use of CO₂ in human body?

We all know CO₂ as a waste product of metabolism . Does CO₂ have any helpful role , apart from having a role in pH of blood ?
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In Japan, the official average body temperature is 36.0 °C. Why so different from that of Europe?

The Japanese Wikipedia states that the average human body temperature is 36.0 °C (here,"ヒト"). The statement references the data from the Japanese government. Actually all of my Japanese friends think ...
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Should we induce fever to assist healing?

I am currently reading "The Fundamentals of Anatomy Physiology" 10th edition, and have found it an incredibly interesting book. I have just been reading about the lymphatic system, and the various ...
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Why are many fruits sour?

Many fruits (like apples, berries, citrus fruits etc.) contain high levels of organic acids, especially malic acid and citric acid. Are there any evolutionary functions of those acids in ripe fruits? ...
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Why is glucose our primary source of energy?

Is there any evolutionary reason for glucose being the "main" molecule used as a source of energy, beginning with glycolysis and subsequently cellular respiration (after being converted to two ...
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Why can't the brain and red blood cells use fuels other than glucose?

The question is rather straight forward: I have always been curious as to why, but cannot find an explanation online. I can imagine that the mechanism is different for each, but why does brain tissue ...
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If so many different hormones/molecules work by activating adenylyl cyclase, how do they have different effects?

It seems that many hormones and molecules work by activating adenylyl cyclase to convert $\text{ATP}$ to $\text{cAMP}$, such as adrenaline and glucagon. Both of these seem to bind to $\text G$ protein ...
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Why our body does not produce polyunsaturated fatty acids?

Our body does not produce two polyunsaturated fatty acids (PUFA): linoleic acid and alfa-linolenic acid. I am thinking reasons for it. Saturated fatty acids have more energy than unsaturated. ...
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What is the brain's preferred energy source? Glucose or ketones?

As with all cells in our body, I know that the brain can get fed from both glucose and ketones, so my question is, given both of them, which one would the brain prefer to utilize first?
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Is there a way to quantify in vivo cholesterol transport rates?

I have always had trouble grasping the physiology of lipoprotein cholesterol transport. The "standard" description found in the literature is that liver synthesizes cholesterol which is carried in "...
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Why are both glucagon and cortisol released in hypoglycemia?

Cortisol is released in response to prolonged stresses; one situation when cortisol is released is when blood glucose level is low. In this situation cortisol acts on adipose tissue promoting fatty ...
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How Does Green Tea Increase Metabolic Rate?

According to the article "Green Tea Supplementation Affects Body Weight, Lipids, and Lipid Peroxidation in Obese Subjects with Metabolic Syndrome", Green tea increases metabolism and fat loss: ...
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What preceded ATP synthase?

ATP Synthase is ubiquitous throughout life on earth and so most probably evolved within the last universal common ancestor (LUCA) before that lineage diversified into the various kingdoms of life. ...
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Where do the four ADPs come from in the second stage of glycolysis?

In the first stage of glycolysis, the two molecules of ATP are broken down into 2 ADPs + 2 Pi through hydrolysis, then in the second stage of glycolysis they are phosphorilazed to obtain 2 ATPs. How ...
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How much does a human brain's metabolic rate vary? [duplicate]

Possible Duplicate: How does brain energy consumption depend on mental activity? Our brains consume about 20% of our energy when we're at rest. How variable is a human brain's energy consumption? ...
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1answer
424 views

Are alpha-ketoglutarate and glutamate involved in all transamination reactions?

Is it true that for all biochemical transamination reactions, that alpha-ketoglutarate and glutamate serve as the amino group acceptor and donor, respectively? If this is true, then is it safe to ...
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How to relate human metabolic model reactions and cancer drug targets / reactome items?

Trying to find a way to take a cancer drug (from CancerDR, for instance) and infer the metabolic reactions that are affected by it in the Human Metabolic Model. Essentially, I would like to know ...
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Relationship between our microbiome and personalized nutrition

Recently, it has been asked whether there are 'metabolic types' between humans that can benefit from a sort of personalized nutrition. One answer suggested that one discerning factor could be the ...
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How long does it take for E. coli to shift feedstocks?

With our fermentations we're noticing that it takes an appreciable amount of time for E. coli (K12 variant) to change from being metabolically streamlined on amino acids to being metabolically ...
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Does mixing alcoholic drinks really make you more drunk?

There is plenty of anecdotal evidence ("beer after wine and you'll feel fine, wine after beer will make you feel queer") that mixing alcoholic drink types leads to a stronger effect, but I can't find ...
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Effect of cold showers after intense training

What is the effect of cold showers after very intense training (body fully covered in sweat, high pulse, increased body temperature)? I'm especially interested in how it affects perspiration.
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How should I feed and keep an ant queen?

I have captured wandering ant queen. I guess she was just fertilised and was looking for a place to start a hive. I'd like to create my own ant hive in artificial environment. I unfortunately only ...
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How many, and how severe, are known single gene polymorphisms for obesity?

A fairly recent meta-analysis of studies examining the association between adult obesity and polymorphisms of the FTO gene (Peng et al., 2011). The paper looked at 59 studies and concluded that, "FTO ...
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Does THC excretion increase if urine volume increases?

In regards to the body metabolizing and excreting THC: if urination is increased as a result of drinking lots of fluids, does that mean that more THC is leaving the body? To rephrase the question, is ...
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Is there such thing as a generic “metabolic type”?

A while ago I picked up a book called "Eat right for your metabolic type". The book discussed the effects of the endocrine system on the overall shape and the speed of metabolism. The book outlined ...
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Can animals make their own unsaturated fatty acids?

I know that animals can't make poly-unsaturated fatty acids (PUFA) and so require them from dietary sources. For eg.Omega -3 and Omega 6 fatty acids. My questions : Can animals synthesize other ...