Questions tagged [mhc]

The major histocompatibility complex is an extremely diverse genome region in vertebrates that is responsible for antigen presentation. There are two main classes, MHC I and MHC II.

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What is meant by 'fixing' of an antigen presenting cell?

Can someone please explain what does 'fixing' of an antigen presenting cell mean?
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Can MHC class I be used for presenting peptides of extracellular origin by non-professional APCs?

Wikipedia says that: "The antigens presented by MHC class II are derived from extracellular proteins (not cytosolic as in MHC class I)." So does this mean that MHC class I cannot be used for ...
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How are Cytotoxic T cells transfered?

We learned that Cytotoxic T cells are MHC dependent, and if CMH matchup doesn't occur between the T cell and the cancer cell for example, the former won't attack the latter. If this is the case then ...
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Mouse H2 allele sequences

I've been trying to find complete sequences of mouse (Mus musculus) MHC H2 locus haplotypes for quite some time now with limited success. The EBI IMGT database has a table of mouse H2 haplotypes, yet ...
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CD4 Proteins & Antigen presenting cells

If Helper T-Cells express CD4+ proteins on their surface to bind to MHC Class ll proteins on antigen presenting cells, why do antigen presenting cells also have CD4+ Proteins?
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Are MHC Proteins the Most Polymorphic Human Proteins Known?

There is a paragraph titled "MHC Proteins Are the Most Polymorphic Human Proteins Known" in the "Molecular Biology of the Cell" by Alberts et al. 6th ed. 2014. But someone has recently told me that ...
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Is the whole MHC haplotype expressed and so their proteins are exhibited on each nucleated cell membrane?

Am I correct if I guess the following (?): If we inherit both maternal and paternal MHC haplotypes, the functional (non-pseudo)genes are expressed and all of their products (MHC molecules) are ...
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Why are kidney discard rates so high?

A recent report from UNOS states: The kidney discard rate has returned to pre-KAS levels, dropping from 20.2 percent in the first six months to 18.4 percent in months 7-10. To me, this seems quite ...
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Corneal transplant and HLA matching

Is HLA matching/ blood grouping required for corneal transplants ? I think,it shouldn't be, because cornea is avascular. I tried searching on the net but most of the references are old and ...
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What is the genomic position of HLA-B*1502 variation?

I've searched the position and SNP ID of HLA-B*1502 variation. However, I couldn't find that where this variant exactly located on genome or HLA-B gene.
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Primer design for HLA locus

i have designed primers for HLA locus DPA1(exon 2 region) based on Real-Time PCR (qPCR) Primer Design guidelines. primer will start from intron regions to cover full exonic region. F-...
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allogeneic organ transplant and the immune response

What happens when an allogeneic organ transplant is performed on an immunocompetent recipient vs. when it is performed on an immunosuppresed recipient using a donated organ with immunocompetent cells?
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Why cytotoxic T cells don't kill dendritic cells when they present antigen?

When a cytotoxic T cell (CTL) recognizes a peptide presented in the MHC-1 of a dendritic cell (APC), why it doesn't kill this cell? I know that initially, in the lymph node, the T cell is inactivated....
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Presence of MHC on red blood cells

Do red blood cells have no MHC? (I have often heard that they do not.) If so why are they not destroyed by immune cells?
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A possible cause of autoimmunity

I read that Doherty and Zinkernagel found that MHC- heterozygotes present more antigens to the immune system than homozygotes; yet, the infected heterozygous mice in their experiment all died, ...
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Variation in MHC in humans

What evolutionary process lead to so much variation in MHC? What is the advantage of having such variation?
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Number of MHCs in neurons

I have read that neurons have proportionately less MHC molecules than other cells of the body. What is the advantage of this?
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Do T-cells express MHC molecules?

T-cells recognize the MHC molecules and body's own peptides. When it doesn't, it alarms the immune system. But do T-cells express MHC molecules ? If so, how are they using it? If not, what happens ...
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Do you know of any disease where HLA / MHC association discovery has led to better treatment or management?

If we discover an association between a disease and a particular HLA type (MHC class I or class II molecule) then it may provide us with some insight into the disease in a very basic way. However, ...