Questions tagged [mice]

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At what age are mice considered too old for their thymus to stop being functional and produce T cells?

I am studying the effects of radiation on the immune system of mice. After exposing them to radiation, we will be harvesting their spleen, lymph nodes and blood to investigate immune cells such as T ...
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0answers
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Treatment validation on mouse models

I am struggling to set up a project proposal for validation of a known treatment for metastatic colorectal cancer in mouse models. I want to see how SNPs in patients contribute to their drug ...
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1answer
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Mouse Colony Software

I am looking for a good mouse colony census program that tracks the mice we have in the lab, breeding success of breeders, lineages, multiple user access, etc. Jackson labs has a program that does ...
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Do I need to use the same WT C57BL individual for back-crossing or can I use a new one for each generation?

I've just received heterozygote C57BL mice from COMP and I need to start back-crossing them. I've read many colony management protocols, but couldn't understand if I need to use the same WT mouse for ...
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1answer
39 views

Primers on Dystonia

Where can I get a good biochemical overview of dystonia? I will be working in a research lab that focuses on dystonia and I would like to not be clueless.
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2answers
85 views

Protocol for measuring stamina of arthritic mice

I am going to make some mice ill with arthritis. The medicine which I am testing as control is known to cause extreme fatigue. I think I've improved it. I'd like to humanly measure their stamina in ...