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Questions tagged [mice]

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How do I find genes related to monocytes in mice gut?

My PI just gave me a task where I've got to find genes related to monocytes in the mice gut using single-cell RNA seq. I feel all out of my depth. I've looked up cell expression atlas but don't ...
jai yadav's user avatar
1 vote
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Knock-Out (KO) Mice

We have generated an induced KO mice line for a specific gene. However when i perform IF staining I can still see substantial levels of the protein for this specific gene produced, even though the ...
shaii's user avatar
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How quickly could mice evolve to avoid mousetraps through artificial selection?

So, we have a mouse problem in our attic. I set traps routinely to keep the population down. We have taken pains to exclude them by sealing cracks and holes, etc., but they still manage to find ...
nuggethead's user avatar
25 votes
1 answer

Why are drug dosages so high in some mice studies?

On reading through some research on the effects of certain drugs I often come across staggeringly high dosages such as in this paper: Römer, B., Pfeiffer, N., Lewicka, S., Ben-Abdallah, N., Vogt, M. ...
kcpm's user avatar
  • 353
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Treatment validation on mouse models

I am struggling to set up a project proposal for validation of a known treatment for metastatic colorectal cancer in mouse models. I want to see how SNPs in patients contribute to their drug ...
Danae Velts's user avatar
5 votes
1 answer

Mouse Colony Software

I am looking for a good mouse colony census program that tracks the mice we have in the lab, breeding success of breeders, lineages, multiple user access, etc. Jackson labs has a program that does ...
The Nightman's user avatar
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3 votes
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Do I need to use the same WT C57BL individual for back-crossing or can I use a new one for each generation?

I've just received heterozygote C57BL mice from COMP and I need to start back-crossing them. I've read many colony management protocols, but couldn't understand if I need to use the same WT mouse for ...
Snork's user avatar
  • 31
1 vote
1 answer

Primers on Dystonia

Where can I get a good biochemical overview of dystonia? I will be working in a research lab that focuses on dystonia and I would like to not be clueless.
Dissenter's user avatar
  • 499
1 vote
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Protocol for measuring stamina of arthritic mice

I am going to make some mice ill with arthritis. The medicine which I am testing as control is known to cause extreme fatigue. I think I've improved it. I'd like to humanly measure their stamina in ...
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