Questions tagged [mutations]

A change in an organism's genomic sequence.

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11
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3answers
577 views

If Tumors have lots of mutations in them how is it the immune system can't detect them?

If a cancerous tumor has a lot of mutations in them why can't the immune system detect them? If a person has cancer could this somehow alter the person's immune system so it doesn't function ...
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2answers
78 views

New ORFs occurring in SARS-CoV-2 due to mutations

Are there examples of new ORFs in SARS-CoV-2 created by mutations? The ORFs should not be present in the reference virus, but they should occur in a lineage occurring in the wild (at best, being part ...
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1answer
28 views

What is the mathematical relationship between selection coefficient and dN/dS

dN/dS is often used as a measure of the intensity of selective pressure on a mutation or gene, but I'm curious about how it can be written as a function of the selection coefficient. I'm specifically ...
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0answers
43 views

Extensions of proteins in SARS-CoV-2 variants

What lineages of the coronavirus SARS-CoV-2 occurring in the wild show some extensions, i.e., mutations of the stop codons to codons encoding amino acids (mutations to another stop codon don't count ...
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2answers
54 views

Do the genes for external viral epitopes mutate faster than for viral machinery (e.g. Proteases)?

To fight SARS-COV-2 we use vaccines which train our immune system against viral epitopes like the external S(pike) protein. Since these structures change a lot, would it not have been a better idea to ...
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2answers
98 views

Coronavirus lineages with amino acid insertions

Is there an overview over SARS-CoV-2 lineages that have some insertions in their genomes? Tools based on GISAID sequences do not show them. I am aware of a few lineages with insertions Mu with S:...
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1answer
89 views

Mutations in a Petri dish overnight

How long does it take for a bacterial culture in a Petri dish to experience all possible single base pair mutations? Can 12 hours be enough? I want to get an intuition for whether a given mutation is ...
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0answers
23 views

Monogenic disorders vs multifactorial inheritance disorders

There's a condition called SYNGAP1-related intellectual disability which is caused by mutations to the SYNGAP1 gene. I believe that this is called a monogenic disorder, while disorders that are caused ...
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1answer
60 views

Do mutations that cause the loss of a complex trait occur more often than mutations causing gain of a complex traits?

The Wiki entry on the evolution of biological complexity states that "[m]utations causing loss of a complex trait occur more often than mutations causing gain of a complex trait". There is ...
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1answer
85 views

How are random mutations in cells of an organism controlled?

Even in the most stable conditions cells undergo mutations. So in humans(an example) with millions of cells, mutations must be a common affair. But how is that we are still basically the same ...
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1answer
1k views

Do mutations occur while growing virus for preparing inactivated viral vaccine?

The development of mutations in virus is reported to happen during replication, especially for an mRNA type virus like SARS-COV-2 Viruses that encode their genome in RNA, such as SARS-CoV-2, HIV and ...
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0answers
55 views

Mutation rate breakdown by original and mutated nucleotide for Coronaviridae

In a discussion of the mutations S:Q677H and S:Q677P in SARS-CoV-2 it was mentioned that the mutations leading to this result are "against the tendency" of preferred mutations on the ...
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1answer
59 views

How to calculate the probability that a mutation occurred?

According to the internet, there is a 7% chance that two brown-eyed parents will have a green-eyed child. However, Dominance says that it is impossible for this to happen. Is the internet correct? If ...
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0answers
17 views

Are the kind of mutations different in an antibiotic setting than they are in a non antibiotic setting?

Hy everyone! I'm looking for experiments that deal with the kind of mutations that arise in antibiotic environment, as opposed to non antibiotic environment. As far as I understand, AB (anti biotic) ...
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2answers
588 views

Have there been attempts to identify Chomsky's "language mutation" in humans?

I'm not versed in either biology or linguistics so please forgive any naiveties I may commit. I've learned that Noam Chomsky thinks that language is a result of a single genetic mutation in humans. ...
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0answers
368 views

Why are adenoviral vector vaccines safe in terms of insertion mutagenesis due to genome integration and E4 region's proteins effects?

Disclaimer: I'm neither a genetics professional nor an anti-vax fanatic, I just tried to compare COVID-19 vaccine types currently available on the market and got some questions that I'd like to answer ...
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2answers
44 views

Are SNPs or SSR copy number variation mutations more prominent?

I'm trying to get a sense of the dominant way that mutations occur. I have seen various numbers which seem at least at first glance to conflict, and I was curious if anyone had clarification on this. ...
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3answers
179 views

Saturated Mutagenesis Screening

I am hoping to mutate the active site of the enzyme I am researching that has 5 residues in proximity with the substrate. I am wondering how many colonies I'll have to assess to theoretically sample ...
12
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2answers
8k views

Are all mutagens carcinogens?

Not all carcinogens are mutagens. Alcohol and estrogen, for example, does not damage DNA. It's one of the assumptions of the Ames test that mutagenicity implies carcinogenicity, but is this always ...
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2answers
131 views

DNA mutations in humans are generally bad, but why to they make viruses stronger?

When I read about DNA mutations in humans, the mutations are generally bad. When I read about mutations in viruses such as the recent emerging strains of COVID-19, however, it seems to be good for the ...
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0answers
71 views

How difficult is it to adapt an existing vaccine to a virus variant?

There is (at least in France) an ongoing discussion about the Astra-Zeneca vaccine which is perceived as "outdated" because of the prevalence of new variants (the vaccine was designed based ...
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2answers
151 views

How can mutation of viruses lead to loss of fit to antibodies without loss of fit to antigen of cells they infect?

Viruses are known to mutate, thereby escaping immune cells and evading vaccination. Given that there is one and the same specificity of the key to both the receptor on the infected cell causing the ...
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5answers
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Is it plausible that strict lockdowns made it more likely for the new variant of COVID to have emerged?

My idea is that strict lockdowns put greater evolutionary pressure on the coronavirus by restricting oppurtunities to be transmitted, meaning that a faster-spreading variant had much less competition. ...
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2answers
107 views

Does a critical mass of infected individuals exist after which mutations will overtake vaccination attempts?

As we know, all organisms have a probability to undergo mutations when they replicate. For every infected individual with the Covid-19 their bodies are environments in which the SARS-CoV-2 may mutate ...
5
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1answer
202 views

At what rate do chromosomal rearrangements occur?

How often do chromosomal rearrangements occur? I am interested about these kind of chromosomal rearrangements that are passed on to the descendants, i.e. germ line chromosomal rearrangements. The ...
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1answer
62 views

Is there an example of a new species through mutation breeding? [duplicate]

Is there a demonstrable species that went through mutation breeding and through successive generations it drifted so far away from its initial parent species that it can't breed with them anymore? (I ...
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1answer
37 views

What is the difference between mutation per base pair and mutation per genome? [closed]

Isn't genome size considered to be the number of base pairs present in DNA? So what is the difference between the mutation per base pair and mutation per genome? Are they similar or different?
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1answer
87 views

What is the probability of virus undergoing a specific dangerous mutation? [closed]

Non-biologist here so apologies if the question is violating too many of the community standards for asking a question in the forum. What got me thinking was imagining how much more terrifying the ...
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2answers
81 views

Coronavirus mutation: bad luck or a consequence of vaccination?

I would like to know whether a mutation within a virus (such as the new coronavirus mutation that appeared in England source) is a consequence of the vaccination program - maybe because it is ...
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3answers
2k views

Are all carcinogens mutagens?

I assume that all carcinogens must be mutagens, but I've read that this is not the case. However, I can't find any good examples or an explanation of why it is not the case. How can a non-mutagenic ...
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0answers
24 views

What is the minimum-volume : neutral-volume : maximum-volume of the molecules that make up the SARS-Cov-2 virus-fusion machine?

The "neutral-volume" is the over-lapping volume between minimum-volume & maximum-volume of the molecules that make up the SARS-Cov-2-fusion machine. Those identifying potential ...
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1answer
32 views

Can the mutation rate vary for individuals of the same species, growing in similar environments?

Suppose we consider several populations who originally inherited their genome from the same ancestor, and that we put for a few thousands generations in similar environments. Could the mutation rate ...
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0answers
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For which animals, can we make iPS-derived reproductive chimeras?

If I'm right, there are two types of pluripotent stem cells: naïve and prime. The naïve form is more undifferentiated. It would seem to me that it would be easier to make genetically engineered ...
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0answers
25 views

Is there something amounting to "check sums" in genetic code?

Humans use checksums for many different applications in informational processes. Genetic code is used as a "program" to synthesize proteins, so it could (I'm a layman when it comes to ...
5
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1answer
197 views

A mutation question from the Indian National Biology Olympiad

DNA was isolated from wild type (Gal+) and mutant (Gal-) E. coli cells and separated by density gradient centrifugation technique. DNA from Gal- strain acquired a lower position. This indicates that ...
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1answer
34 views

Could a mutation on neutral part of genome become deleterious?

I know that silent mutations are neutral because they dont affect function of the protein/gene, and a missense mutation would. But lets say both occur on a neutral portion, could one or the other ...
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0answers
16 views

Would an enrichment of pyrimidine runs of two of more nucleotides be an early indicator of DNA to be damaged?

I am analysing two categories of protein coding genes comparing their relative characteristics. What I am observing is that one of these, in comparison to the other, is enriched in pyrimidine runs (...
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0answers
19 views

Estimate mutation rate in UVC treated cells

I am wondering how to get a coarse estimate of the number of mutation I obtain doing UVC treatment on eukaryotic cells (microalgae) starting from information such as the survival rate, genome size, ...
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2answers
757 views

What is the modern state of the theory of evolution?

When I studied biology at my medical school, we used to learn topics around a century old: the famous Darwin's voyage on "Beagle" to the Galapagos Islands, the classical triad of his Theory ...
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1answer
71 views

At what point during an organism’s lifespan do mutations occur?

I’m a software developer and I’m implementing something called a Genetic Algorithm. I would like some input on when during an organism’s lifespan mutations occur. Genes mutate throughout the lifetime ...
8
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1answer
133 views

Who invented dN/dS?

I am writing a paper, and I want to refer to the original paper that coined the term dN/dS (or Ka/Ks for that matter). I have found early works on dN and dS (like Miyata and Yasunaga 1980), but cannot ...
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1answer
71 views

Why is the relative expression in qPCR so low?

When analyzing different mutations through qPCR I found the $2^{-\Delta\Delta ct}$ value for each mutation. All the mutation have similar values compared to the wild type gene, however one of the ...
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0answers
38 views

When cancer is detectable, how many sub-clones are there at that stage?

I have read somewhere that cancer is detectable when the number of cells reaches $10^7 - 10^9$, which probably varies according to the specific tumor. At this early stage, what is the expected number ...
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1answer
48 views

Are probabilities of mutations symmetric?

For the premise of this quiestion let's assume that there is an allele A and an allele B. The allele A has a probability P to mutate into the allele B in the given timeframe. Is it also true that the ...
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1answer
157 views

Is natural selection actually random?

In the Theory of Evolution, two main factors take place: One is random, which are the different mutations that organisms' DNA suffer. This process adds genetic variability to a given population. The ...
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1answer
54 views

De novo mutation selectivity

I was recently reading about genetic diseases and came to understand that many of them are caused by de novo mutations in the prezygotic or early embryonic stages of the life cycle of the organism. ...
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1answer
46 views

gene inversion and DNA directionality

The directionality of the DNA goes from the 3-prime end to the 5-prime end. Thus, the inversion of a gene would connect a 5-prime to a 5-prime. How could that be? Maybe inverting a gene also ...
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1answer
76 views

Are there known chains of beneficial mutations?

Are there known examples of chains of beneficial mutations? What I mean by that is a mutation that leads to a series of mutations occurring after each other over a relatively short period of time ...
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1answer
120 views

Can mutation take place in G1 and G2 phases during the cell cycle?

We know that the DNA replicates during the S phase in Interphase. There it might undergo a number of mutations. We also know that the forward half strands are more susceptible to undergoing a mutation ...
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1answer
29 views

Why the major gene model can be supported by finding de novo mutations in affected cases?

I found a sentence which I can't fully understand in a publication on the genetics of autism. The unified major gene model is supported by the significant increase in damaging de novo mutations ...

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