Questions tagged [mutations]

A change in an organism's genomic sequence.

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20
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4answers
5k views

Are mutations a source of genetic variation?

Here is a question from the book SAT II Success Biology E/M (where the SAT is the exam taken by the American high school students): Which of the following statements is true about mutations? (A) ...
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How do we explain the white feathers of an albino peacock?

Peacock feathers are supposed to produce colours by surface structures modulating the light (in addition to the usual absorption/reflection mechanism)... https://en.wikipedia.org/wiki/...
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1answer
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How many times has SARS-CoV-2 mutated?

According to Coronavirus has mutated at least once The novel coronavirus that has infected thousands of people across the world may have mutated at least once — meaning there may be two ...
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2answers
657 views

Looking for a cancer drug target database to guide sequencing of patient tumor DNA

I have a question I would like to pose to the community. I have recently received access to a bench-top ion torrent DNA sequencer. Our idea is to use this machine to sequence the DNA from patient’s ...
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3answers
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Are all carcinogens mutagens?

I assume that all carcinogens must be mutagens, but I've read that this is not the case. However, I can't find any good examples or an explanation of why it is not the case. How can a non-mutagenic ...
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3answers
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Number of beneficial mutations cataloged?

I can see from Wikipedia that there are possibly thousands of harmful mutations that have been cataloged and linked to disease. There are also unnumbered neutral mutations. But, does anyone know how ...
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2answers
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Are all mutagens carcinogens?

Not all carcinogens are mutagens. Alcohol and estrogen, for example, does not damage DNA. It's one of the assumptions of the Ames test that mutagenicity implies carcinogenicity, but is this always ...
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If Tumors have lots of mutations in them how is it the immune system can't detect them?

If a cancerous tumor has a lot of mutations in them why can't the immune system detect them? If a person has cancer could this somehow alter the person's immune system so it doesn't function ...
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What is the modern state of the theory of evolution?

When I studied biology at my medical school, we used to learn topics around a century old: the famous Darwin's voyage on "Beagle" to the Galapagos Islands, the classical triad of his Theory ...
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How close genetically is the most human-like chimpanzee to the most chimp-like human?

I understand that: Chimpanzees are the closest species to humans genetically. Only 1%-6% of their genes are different. Within any species there is genetic diversity, i.e. no two individuals have the ...
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1answer
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Do mutations occur while growing virus for preparing inactivated viral vaccine?

The development of mutations in virus is reported to happen during replication, especially for an mRNA type virus like SARS-COV-2 Viruses that encode their genome in RNA, such as SARS-CoV-2, HIV and ...
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Which bacteria have the highest mutation rate?

From my reading on M. tuberculosis, I know that this organism has a pretty high mutation rate due to uncorrected sloppy replication, which leads to a high rate of development of spontaneous resistance ...
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Why are adenoviral vector vaccines safe in terms of insertion mutagenesis due to genome integration and E4 region's proteins effects?

Disclaimer: I'm neither a genetics professional nor an anti-vax fanatic, I just tried to compare COVID-19 vaccine types currently available on the market and got some questions that I'd like to answer ...
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Is Mutation Theory still "valid" for complex organisms?

I'm afraid like most people I suffer from having learned "A History of Evolution" in school, rather than cutting to the chase and learning the actual "up to date" version of the subject. (Imagine if ...
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How does Darwinian Evolution work?

Let me explain... A friend and I read some articles, part of a Biology book, and watched a video on evolution. We then tried to explain what Evolution is to each other. My friend said that Natural ...
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2answers
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Are STOP codons impacted by base insertion or deletion mutation?

I am learning about base insertion and deletion mutations. An example in my textbook is given below. GUU CCA CAU AUC. So if there is an insertion (of guanine): GUU GCC ACA UAU C_ _ (there will be a ...
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Can cancer cells in the same person, organ, and origin have different DNA?

Is it possible for cells from the same tumor to have different genetic material, and if so, to what degree is it possible (how fast do they mutate) ?
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Have there been attempts to identify Chomsky's "language mutation" in humans?

I'm not versed in either biology or linguistics so please forgive any naiveties I may commit. I've learned that Noam Chomsky thinks that language is a result of a single genetic mutation in humans. ...
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1answer
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Who invented dN/dS?

I am writing a paper, and I want to refer to the original paper that coined the term dN/dS (or Ka/Ks for that matter). I have found early works on dN and dS (like Miyata and Yasunaga 1980), but cannot ...
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Difference between mutation and DNA damage

What is the strict difference between mutation and DNA damage? As far as I understand it, a mutation is an alteration in the genetic sequence, having "tricked" the repairing machinery and thus ...
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What has caused life to choose this unfathomably tiny subset of all possible proteins?

I wonder why life uses the particular proteins that it does, about 10^6 different proteins, I think? Evolution cannot explain it because the number of possible proteins is far far too large to ever ...
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2answers
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Are mutations random?

The following claim Mutations are random or just the use of the expression Random mutations are very common among lay people. The claim is very common among lay people. The claim is often ...
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Isn't biological immortality strictly speaking impossible?

This question relates to both immortal cells such as cancers and organisms like the Hydra genus. Isn't it technically impossible for these "immortal" biological systems to live forever, even ...
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Cancer biology: Can tumors form from cells that are genetically identical to non-cancerous cells?

Can a tumor begin to form without any genetic mutations? I'm specifically interested in a tumor which could later lead to cancer.
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1answer
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Are four-leaf clovers mutations, developmental errors, or something more complicated?

What causes about 1 in 10,000 clovers to have four instead of three leaves? Will progeny(?) grown from its flower's seeds have a higher probability than that of also having four leaves? From the ...
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4answers
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Why does DNA mutate?

I just read that pregnancy in space would be super dangerous because - among other reasons - of a higher risk of mutations due to radiation. This made me wonder: why does the DNA in organisms mutate? ...
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What is the standing genetic variation?

I am reading this review. In the first part, the author introduces Standing Genetic Variation, described as: STANDING GENETIC VARIATION Allelic variation that is currently segregating within a ...
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1answer
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Why do haemophillic females $X^hX^h$ die before birth?

I just came across a statement in my book , while reading genetics, that haemophiliac females do not survive till birth (the reason not mentioned here why) . Before posting this question here I ...
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3answers
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Following DNA replication during S-phase of the cell-cycle, are all genomic regions subjected to the same stringent level of DNA-Repair?

To my (limited) understanding, there are 2 main ways that mutations can occur in DNA: Environmental (UV, etc) and mistakes during cell division. I was wondering if there is a mechanism that can give ...
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1answer
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Do organisms have a mechanism to control how fast mutations occur?

Sometimes the environment and other species can change rapidly (climate changes, changes in terrains from erosion, new river paths, etc), and it seems like a regular slow mutation rate would be bad, ...
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1answer
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Is it possible to express a mutant gene only in a specific tissue?

Imagine that someone tries to develop a knockout mouse for a gene, but this result in lethality for the homozygous. Is it possible to express that mutant gene only in a specific tissue of interest to ...
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(How) can a pink grasshopper exist?

I saw this foto on Reddit recently: Is this possible? How can a grasshopper become like this? Is this just natural genetic mutation?
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Correlation between genome size and mutation rate?

Martin Nowak in his book "Evolutionary Dynamics" talks about a given correlation between genome size and mutation rate. What correlation does exactly exist between these two concepts? Is it a linear ...
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1answer
795 views

How do scientists create specific mutations?

Suppose I want to create a mutant like Antennapaedia how will I go about accomplishing it ? I know that radiation and certain chemicals are mutagenic. So do scientists subject animals to such ...
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1answer
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How do point mutations arise from mistakes in DNA replication?

Hi! I'm trying to make sense of this illustration (from the textbook Biological Science by Scott Freeman). The general question is: How do point mutations arise from mistakes in DNA replication? If ...
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1answer
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Are there any mutagens that can undo the mutations they cause?

I was reading a section from my textbook about tautomeric shifts, and it seems to suggest that there are some mutagens that can be directly responsible for the phenomenon. The section is mainly ...
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1answer
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How well supported is the hypothesis that aging is mainly caused by the number of mutations in tissues?

I heard the hypothesis, that the (main) reason of aging is the increasing number of mutations in body tissues. The higher the number of mutations is, the older tissue is. Is this true? And how well ...
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1answer
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Mutation-immunity in Luria-Delbruck experiment

If experiments like those of Luria and Delbruck on E. coli and T1 phage are the main source of our confidence in the mutation-immunity model, is it then highly unlikely that there are other types of ...
6
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1answer
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How does bonding between non-complementary bases occur?

My teacher told me that when DNA polymerase makes an error (roughly every 10 million nucleotides?) that if, for example, it matches an A with a G that the error remains and is the main cause of point ...
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1answer
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How can the phenotypic effects of a tumor suppressor mutation be silenced?

I've been reading a little about the "two-hit" hypothesis for tumor suppressor genes here, which mentions that some genes exhibiting haploinsufficiency are exceptions to the hypothesis. I've read ...
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Do mutant alleles result from mutation of the wild type?

The allele that encodes for the most common form of a phenotype in natural population is called a wild type allele and all the rest of the alleles encoding forms other than the wild type are called ...
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1answer
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What is the difference between Single Nucleotide Polymorphism (SNP), Mutation and Structural Variation(SV)?

This is a question which plagues many people and today I was wondering it myself while writing a grant. Indeed, I've seen many people use the terms interchangeably, but they are all very different ...
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3answers
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Saturated Mutagenesis Screening

I am hoping to mutate the active site of the enzyme I am researching that has 5 residues in proximity with the substrate. I am wondering how many colonies I'll have to assess to theoretically sample ...
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3answers
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What is the difference between silent and synonymous mutations?

Several sources all caution that silent mutations and synonymous substitutions are not the same thing and should not be confused. But they seem to draw different actual distinctions between the terms: ...
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2answers
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A and AB blood types from B and O?

My grandma is O- blood type, my grandpa is B+, but my mother is A+ and my aunt is AB+. Is that possible? I've just looked at different sources like this and all of them are saying that from O and B, ...
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Are the changes required to produce genetically manipulated organisms (GMOS) considered to be mutations

By definition, are mutations required to be natural, or are synthetic lab-induced genetic changes considered mutations too? Furthermore, are genetically manipulated organisms (GMOs) considered forced ...
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1answer
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Most human-like teratoma ever recorded?

I'm curious to learn about the 'most human' teratoma ever recorded. By that I mean a teratoma which most resembles the form of a human being. I suppose there are several factors which would ...
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1answer
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A mutation question from the Indian National Biology Olympiad

DNA was isolated from wild type (Gal+) and mutant (Gal-) E. coli cells and separated by density gradient centrifugation technique. DNA from Gal- strain acquired a lower position. This indicates that ...
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How do transgenic transformations cause off-target phenotypes?

I read that transgene insertions can cause off-target mutations that result in a phenotype being overly ascribed to the transgene, e.g. the increase of lifespan being ascribed to Sir2 overexpression (...
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What does 'direction' mean in the statement "mutations are non-directional"?

I was reading the Mutation theory of De Vries; there I encountered this following statements Mutations are discontinuous, random & non-directional.This is in contrast to Darwinism where ...

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