Questions tagged [neurodegenerative-disorders]

Neurodegenerative disorders are disorders characterised by progressive neuronal cell death.

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Recent developments in the diagnosis of Parkinson's Disease

I was reading a research paper titled - "Discovery of Volatile Biomarkers of Parkinson’s Disease from Sebum" by Drupad K. Trivedi. I am Providing a short summary of it. Discovery of ...
Ankush Yadav's user avatar
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Is there in vivo evidence of Amyloid beta toxicity?

Amyloid beta is thought to be toxic, however from a brief search, this is based on (1) in vitro (2) measurements of some proxies of toxicity (e.g. Ultrasensitive Measurement of Ca2+ Influx into Lipid ...
guzey's user avatar
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Can Huntington's Disease be homozygous dominant?

Can Huntington's Disease be homozygous dominant? I am not sure whether the individual who is homozygous dominant for Huntington's Disease will survive into adulthood, or die when they are infants or ...
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Do lychees cause encephalitis?

In India, there is a recent outbreak of this disease after many consumed lychees. Many people link this to lychee's "toxins". I'm not a biology major hence can't elaborate further on this, but here ...
user226375's user avatar
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Why are prions in animal diets not destroyed by the digestive system?

According to CBC: Mad cow disease is the common name for a condition known technically as bovine spongiform encephalopathy, or BSE. [...] The only known source of mad cow disease is from animal-...
Milla's user avatar
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What is it that specifically kills ALS patients?

ALS is a fatal motor neuron disease, and even though there are many different articles out there on the topic "How does ALS actually kill you?", none of them really delve deep enough into biology to ...
smeeb's user avatar
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Are axons capable of endocytosis?

There is evidence for the uptake of toxic substances like prions from the cell bodies of neurons via endocytosis. There is also evidence for prion deposition in white matter. But I haven't been able ...
vrume21's user avatar
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How much should one smoke in order to prevent Parkinson's? [closed]

There are studies who claim that nicotine has a neuroprotective effect against Parkinson's(such as this: What would be the minimum amount of nicotine(...
Flowryn's user avatar
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Of people who develop Alzheimer disease, are those people genetically predisposed to it?

I have read a lot lately about microbiological pathogens that are found in blood vessels in the brain of patient's with Alzheimer disease (positive association). So, I am confused whether there are ...
SSimon's user avatar
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Why to use transgenic mice in ALS models?

In ALS mice model with mutant SOD1 - there are use of transgenic mice, with insert of human mutant SOD1. Why is that? Why not to mutate directly mice SOD1 ? In transgenic mice, after few generations ...
Robertos's user avatar
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Why does ALS start in middle age?

Amyotrophic lateral sclerosis (ALS) often starts at middle age, but I didn't find any suggestion why. Something seems to trigger the symptoms in middle age. If I am not mistaken, the sporadic ALS is ...
Robertos's user avatar
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Does breath-holding cause permanent brain damage?

My question is: Does voluntarily holding your breath at atmospheric pressure for a few minutes can cause brain damage? I'm talking about periods of time around 3 minutes. I've read there are some ...
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What is the mechanism behind tinnitus?

I seem to have come across two contrasting explanations for tinnitus induced by loud noises- i.e. damage to the hair cells in the cochlea. On the one hand, I have read that damage to the hair cells ...
Meep's user avatar
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24 votes
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Why do adults lose hearing at high frequencies?

Children and teens can hear high pitched sounds that adults can't hear anymore. Why do adults lose high-frequency hearing?
ZZZ's user avatar
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7 votes
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Congenital blindness due to retinitis pigmentosa - does it exist?

Retinitis pigmentosa (RP) patients typically become blind after a period of years in which their eye sight slowly deteriorates due to photoreceptor degeneration. Generally RP patients develop night-...
AliceD's user avatar
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3 votes
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The use of proteins in memory creation

I have very limited knowledge of how the human memory works as I think, at this time, most people do. However, I have been reading and some articles which say, and I quote the article just linked ...
Harvey's user avatar
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Do insomniacs yawn?

According to wikipedia, the jury is still out on the function a yawn serves. The article referenced above however writes to say Yawning most often occurs in adults immediately before and after ...
Everyone's user avatar
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8 votes
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What causes autism?

What causes autism? By this I don't mean what is to blame i.e. Vaccines, Gluten or Pharmaceuticals etc.. I mean what exactly is happening in the brain to cause the autistic behaviors such as little ...
Four_0h_Three's user avatar
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What factors govern the variable age of onset in Huntington's Disease?

"Huntington's disease (HD) is a neurodegenerative genetic disorder that affects muscle coordination and leads to cognitive decline and psychiatric problems." As we all know, this genetic disease ...
LanceLafontaine's user avatar
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What does effect would Sulforaphane have on Kennedy's Disease?

Sulforaphane is a isothiocyanate found in cruciferous vegetables including broccoli and cauliflower. Its 2D structure is as follows: It's been found to serve as a histone deacetylase 6 (HDAC6) ...
Josh Pinto's user avatar
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What are some of the immediate challenges to break through before finding a cure for mad cow disease?

What are the immediate challenges to break through in seeking a cure for mad cow disease? I know that mad cow disease has no treatment as of yet.
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