Questions tagged [neuroscience]

The study of the structure and function of the nervous system and its components.

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36 views

How easy is it for quantum dots to enter the intracellular portions of cells?

As quantum dots have better quantum yield than organic dyes, many are being developed as a substitute for them. Nonetheless, could these substitutes be small enough to enter inside cells as current ...
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Image recognition for neuron-astrocyte connections

For my research, I am interested in training a deep learning model to recognize images of brain circuitry. From my understanding, there is technology for detecting neuronal wiring (neuron-neuron ...
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Question about using primary neuronal cultures from mice to support findings from in vivo models

I am analysing synapse formation during early postnatal development using the brains of postnatal day 2 (P2) and postnatal day 10 (P10) wild-type and knockout mice. Through Western blot analysis, I ...
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1answer
41 views

What is the process by which fluorescent proteins in two photon microscopy are optically stimulated by membrane depolarization?

How does the flow of calcium ions through neurons cause the dyes to activate? The voltage is extremely small, so the dyes have to be extremely close to the neurons, which would disrupt the cells, so ...
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Toxoplasma gondii

Very widespread. It infects most mammals but can only reproduce in a cat. Sapolsky indicated that an infected mouse has less aversion to cat urine than an uninfected mouse. So lessening aversion ...
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Clarifying Resting membrane potential [duplicate]

I need some help understanding how the resting membrane potential is maintained in neurons. I understand that there are more K+ leak channels than Na+ leak channels, meaning that more K+ ions leave ...
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3answers
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Is there a difference between human neuron cells compared to those of other animals?

Thanks for looking. Firstly, I am nowhere near biologist, just a student, so my apologies if this isn't a "good" question. Background: So I was searching about intelligence, brains and ...
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1answer
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How are electrodes working? (EEG) [closed]

How do electrodes receive signals from the brain when using/doing an EEG? Is there some "circuit" for it? Is it harmful if you have many (more than 50-100) on your head? I found out that ...
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1answer
53 views

Cumulative synaptic transmission delay

Assume the following: there are at least 10^11 neurons in the human brain there are approximately 10^14 synaptic connections in the human brain (because on average each neuron gets inputs from ...
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How Fast can the Electrochemical Gradient on a Neron be Reestablished?

The electrochemical gradient of Na+, K+, Ca2+, and Cl- between the inside and outside of a neuron is vital for its function. When a neuron fires, this gradient reverses. How long does it take for the ...
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1answer
37 views

Read neural activity only having access to the brain from the “outside”

Is it possible to read neural activity from the outside of the head and if you had an machine learning algorithm that could learn what the signals "mean" (for example moving the right arm)? ...
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56 views

Purposeful usage of Synaptic Pruning

Is it possible to make use of synaptic pruning after age of 20 so to purposefully dislike something you do on habit (Like eating more, smoking, etc.)? What happens in people's brain from the ...
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How do brains find the peak/valley point on a curve?

It costs O(n) time if we find the max/min value in a number sequence with the length n. However, if we convert this sequence into a curve and find the peak/valley point with our eyes, it will use much ...
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19 views

Specified effect of trans cranial electric stimulation on neurotransmitters

Can a specific voltage from a trans cranial stimulation activate specific neurotransmitter receptors or channels? By specific, it means receptors dedicated to specific neurotransmitters such as ...
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75 views

By what means do “nerve agent” compounds like VX spread through the human body so quickly?

It has been demonstrated that so-called nerve agents are able to incapacitate and kill a human in only minutes after exposure. One such substance, VX, only requires a few milligrams to contact the ...
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How does the presynaptic terminal stay at the postsynaptic neuron? [duplicate]

I wondered about this because the two neurons never actually touch. The synaptic cleft is very small, but if there is no connection the neurons might easily separate... [in chemical synapses]
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1answer
60 views

Is there an 'opposite' neurotransmitter to dopamine?

Dopamine is a neurotransmitter (i.e. chemical) in the brain that gives us great feeling. From here: Dopamine plays a role in how we feel pleasure. It's a big part of our unique human ability to ...
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Does estrogen have a more potent neural pruning effect in adolescence than testosterone?

I have read a study here which finds that female rats with their oestrogen inhibited had more neurones in a region of the visual cortex than intact female rats. To me, this suggests that estrogen may ...
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How does expansion of the skin via mitosis influence the density of its specialised nerve endings

I found a reddit question Do nerves & nerve endings expand with skin or does skin expansion causes loss of nerve density where a user references the study Assessment of Epidermal Nerve Fibers: A ...
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1answer
34 views

What is the number of synaptic vesicles in an axon terminal?

Is there any research as to the average number of synaptic vesicles per axon terminal in a human neuron's axon? On top of that, what percentage of those vesicles are used in a single action potential ...
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11 views

Is B27 necessary to culture neural stem cells?

I've seen many papers using B27 (e.g. https://pubmed.ncbi.nlm.nih.gov/24694094/ & https://www.sciencedirect.com/science/article/pii/S0167488919300242) but it is really expensive and I was ...
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1answer
103 views

Why do women have less synapses / neurons / brain mass than men despite having the same average IQ?

I don't mean to cause offence or suggest than men and women shouldn't be of the same intelligence — that's not something I'm here to dispute. What I want to understand is how this is possible given ...
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1answer
26 views

Connectivity Relation between axon terminal synapses and dendrites

With regards to the synapses between axon terminals and dendrites, what is the relation between a given neuron's axon terminals and its neighbouring neurons' dendrites? Does each axon synapse on only ...
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2answers
111 views

What makes the neurons of the auditory nerve with such high-speed?

What makes the neurons of the auditory nerve with such high-speed? So the most labile are the fibers of the auditory nerve, in which the frequency of the generation of PD reaches 1000 Hz, while for ...
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Are bFGF and/or EGF necessary in NSC expansion medium?

My understanding is that it isn't necessary since it appears that the idea behind a feeder layer is that the stem cells produce their own bFGF & EGF along with other growth factors. Yet I've still ...
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23 views

Brain centers vs areas (and how they relate to nuclei)

I'm looking for a reputable source that can provide succinct definitions differentiating the following terms in the central nervous system (CNS; particularly in the brain): Area Center Nucleus ...
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57 views

Why is there a notch in the Na curve for an action potential?

Just out of curiosity, why does the Na curve dip down like in the figure below? I can't seem to find an explanation!
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Neanderthal minibrains vs human minibrains

Minibrains are lab-grown balls of neurons that have some (distant) semblance to a brain. One study showed that cells with the genome replaced with Neanderthal genes produced mini-brains that were &...
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In-plane rotation of vectors of neural population responses

In this paper on fear conditioning, the following is given: The n-dimensional population vector (activity of n neurons) evoked by the conditioned stimulus (CS+, auditory tone) before conditioning The ...
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1answer
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Comparing angles between population vectors of neural activity

I am reading this paper on fear conditioning, where the following is given: The n-dimensional population vector (activity of n neurons) evoked by the conditioned stimulus (CS+, auditory tone) before ...
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53 views

How are thoughts biologicaly generated?

I want to know how thoughts are biologicaly generated. I know that electrical impulses can trigger formed memories in the brain but what I want to know is how the electrical impulse is generated in ...
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Why exactly does UMN lesion cause hypertonia?

The corticospinal tracts are excitatory in nature (Glutaminergic). So damage of the CST would mean less excitatory input to the LMN. By this logic, there should not be hypertonia. What is the ...
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What are “inactive” cells during Ca2+ imaging of neurons?

I am reading this paper, and have found the following Figure (Extended Data Figure 5) where they show maps of active cells in the amygdala as imaged with a miniscope and GCaMP6m: Legend: Using the ...
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1answer
66 views

Can we decode memories?

Premise: I don't have a strong background in neuroscience or human biology, so I would ask you to answer like you would at a 5 years old child. I have done a couple of research on the web, as well as ...
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1answer
35 views

Are synaptic boutons always located on axons?

I am learning about the protein Synaptophysin and I have read that it is an integral membrane protein localised to synaptic vesicles. I have also read that it is a specific and sensitive marker for ...
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1answer
25 views

What is meant by the term synaptic targeting?

I am studying whether a protein interacts with the mitochondria in the synapses of neurons and I have come across the term "synaptic targeting". I am reading this paper and I have come ...
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Is there a word that describes symmetrical correlations between a damaged brain region and behavioral disability?

Specifically, I'm looking to address phenomena such as (1) how damage to only one side of the substantia nigra leads to Parkinson's symptoms on only one side of the body, or (2) retinotopy, how ...
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26 views

Can Inositol triphosphate (IP3)-mediated Calcium release on its own cause membrane depolarization?

This is about smooth muscles. I know that the Voltage-operated Ca²+ channels on the smooth muscle membrane can be opened by membrane depolarization to threshold. I also know that this depolarization ...
2
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1answer
69 views

Why is gyrification advantageous?

Standard 'Explanation': I've seen countless neuroscience articles and experts explain that 'cortical gyrification is advantageous because it increases surface area which obviously increases your ...
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1answer
42 views

Would tinnitus be explained by perpetually-bent/opened hairs in the cochlea?

When I look around for what causes tinnitus and the like, the usual response is "Well, loud sounds and hearing damage" but I feel like that's a little plain and I am curious about the ...
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1answer
548 views

How does pressure travel through the cochlea exactly?

I cannot find this answer anywhere. What I do know is that the stapes pounds on the round window of the cochlea and this causes the fluid to move inside the cochlea itself, which has the three ...
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1answer
36 views

Why do water molecules diffuse along axons direction?

I am studying tractography technique which aims to reconstruct bundles of axons in brain by following the diffusion direction of water. It is very interesting because it is non-invasive. It exploits ...
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3answers
14k views

Are humans more adapted to “light mode” or “dark mode”?

I was discussing with a colleague about using dark-mode vs. light mode and remembered an article arguing that humans vision is more adapted to light-mode rather than dark-mode: I know that the trend “...
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24 views

Has anyone tried using functional near-infrared spectropathy to quantitively measure sodium concentrations in the brain?

Functional near-infrared spectropathy "fNIRS", is a biophysics/medical technique that uses the near-infrared part of the electromagnetic spectrum (around 680nm to 810nm in wavelength) to ...
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1answer
85 views

Looking for source: Biologic reactions of people saying “no” [closed]

Searching for this topic is incredibly tedious because the word "no" is the main point of interest and I always end up on sites saying how "saying no is good for your health" but I ...
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2answers
67 views

Distribution of hearing loss

Low-frequency sounds are more penetrating, damaging. Hearing damage caused by blasts typically occurs at frequencies around 2 - 8 kHz, while age-related hearing loss starts at the high frequencies. ...
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1answer
93 views

Can scientists “see” thought?

Touching an object activates a nerve - something that can be observed by scientists. Scientists can also trace the resulting "signal" through your nerves to your brain. They may know which ...
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1answer
56 views

Why don't sodium Voltage Gated Channels open during Repolarization?

During Depolarization the Sodium VGC open when they receive the Threshold Stimulus. But when Repolarization occurs there comes a point when the cell interior has exactly the the same potential that it ...
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Is the neural area TEO distinct from the inferotemporal cortex?

I am finding conflicting literature with regards to the division of the inferior temporal (IT) cortex of the brain. For some, I see that area TEO is equivalent to the posterior IT. Which would make ...
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Using coefficient of variation (CV) for GCaMP6 'synchronised episode' spikes, good idea or not?

Using GCaMP6 we have recorded fluorescence activity of kisspeptin neurons that exhibit synchronised pulsatile firing activity. I measured the intervals between each episode, which are quite variable. ...

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