Questions tagged [neurotransmitter]

Small molecules involved in the propagation of a nerve signal across the synapses.

22 questions with no upvoted or accepted answers
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547 views

Can dopamine antagonists be used as dopamine upregulation?

Can dopamine antagonists such as Thorazine that are used to treat schizophrenia and bipolar be used to upregulate dopamine in the long term in healthy (non schizophrenic or bipolar) users to get a ...
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52 views

Does Doxylamine have any Influence on the Monoaminergic System?

Does doxylamine have any affects on the monoaminergic system? Specifically I am interested in adrenergic or serotonergic activity but additional information on its dopaminergic activity won't hurt ...
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0answers
745 views

Acetylcholine and muscles- excitatory or inhibitory? (muscle atonia and myasthenia gravis)

I have heard that acetylcholine can be excitatory or inhibitory, but I am confused as to which it is when it comes to muscles. On the one hand, I believe that muscle atonia during REM sleep is ...
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51 views

What Effect Does the Endocannabinoid System have on Monoaminergic Neurotransmission?

I know that Δ9-tetrahydrocannabinol and other cannabinoids increase dopaminergic neurotransmission in the nucleus accumbens and that this is what results in the euphoria experienced by cannabis users. ...
2
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0answers
32 views

To what extent does the distribution of nerual transmiters in the brain vary human to human?

Suppose $x$ is a position in the brain, and $n_i(x)$ is the density of neuro recepter $i$ around that point. Any given human will have some distribution of neruo recepters $n_i(x)$ through out there ...
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111 views

Loss of nerves in asthma

This site says: VIP [vasoactive intestinal peptide] nerves are absent in severely asthmatic subjects. Mice with targeted deletion of the VIP gene exhibit histopathologic features of airway ...
2
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51 views

What are the on-rate and off-rate constants for 5-HT1 receptors binding 5-HT?

The class of 5-HT1 receptors binds serotonin (5-HT) reversibly (Wikipedia). I'm interested in the on-rate and off-rate constants $k_{\text{on}}$ and $k_{\text{off}}$ of this process. So my question ...
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40 views

Is it reasonable to assume that RNA polymerase would bind preferentially to the promoter of the long allele of the SERT gene?

I'm trying to come up with an idea for a school project (a hypothetical research study). I'm looking at depression and the serotonin transporter gene, which is highly expressed in the human ...
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77 views

How long does it take the neurotransmitters to diffuse accross the synaptic cleft?

Neurotransmitters get from the pre-synaptic neuron to the receptors on the post-synaptic neuron by diffusion across the gap between these two (the synaptic cleft). My question is, how much time does ...
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46 views

What substances can selectively destroy certain cells?

Recently, I've watched a documentary about how, in the 1980s, people were buying and using drugs from the streets and then becoming paralyzed a few days afterwards. The drugs that they were using were ...
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57 views

Visual maps of the neuronal membrane

There are lots of visual maps of the brain as a whole, especially the cortex, that show the distribution of "features" over a two-dimensional map, e.g. the Brodman areas (their morphology and their ...
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152 views

If I receive dopamine only from doing difficult things will I eventually enjoy them?

I've recently read a post from reddit about how dopamine affects our motivation. Author states: Dopamine is pleasure. Your brain craves more pleasure. You get too much pleasure and your brain adapts ...
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182 views

How does the brain manifest and realize the intention to resist sleep?

The question title says it all. What happens in my brain when I resist sleep? I would appreciate explanations on neurotransmitter changes, what areas of the brain activate to resist sleep, what can an ...
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41 views

Gastroenteritis virus causing mutation of the Enterochromaffin cells

I am working on the solution to a worldwide problem: IBS or chronic diarrhea following a viral gastroenteritis infection. I think I have an answer. The only missing piece to the puzzle I found in a ...
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33 views

Does regulate always mean suppress when it comes to heteroreceptors?

Do heteroreceptors always suppress the release of the neurotransmitter they regulate upon their (the heteroreceptor's) activation?
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19 views

Specified effect of trans cranial electric stimulation on neurotransmitters

Can a specific voltage from a trans cranial stimulation activate specific neurotransmitter receptors or channels? By specific, it means receptors dedicated to specific neurotransmitters such as ...
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12 views

Using serotonin for relief from allergies

When someone suffers from an allergy, due some allergens they are given drugs like anti-histamine, adrenaline or serotonin. How does serotonin affects the body to give a relieve from the action of ...
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66 views

Action potential frequency presynaptic neuron comared with in post-synaptic neuron/ muscle cells

I am a physicist interested in knowing how the action potential frequency in a presynaptic neuron compares with that in a) a post-synaptic neuron and b) membrane depolarisation of muslce cells, ...
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71 views

Solubility of lithium carbonate in blood

When a person with Bipolar Disorder ingests a pill of $\ce{Li_2CO_3}$ and it enters the stomach the pill cap is dissolved in the hydrochloric acid; however, when it gets absorbed in the blood how does ...
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1k views

Can human be emotionless?

Is it possible that a person can't produce, like, dopamine, serotonin, and other emotion hormones? Or, a part of the brain can't function to make one feel something?
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1answer
9k views

How long does it take for dopamine to reach normal levels after a significant drop?

The building block sequence for is: Phenylalanine << Tyrosine << L-Dopa << Dopamine. It’s produced in only a few, very specific regions: Substantia Nigra and the Ventral Tegmental ...
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1answer
38 views

Alternative hypothesis for learning in brain beyond the hebbian rule

I was reading on wikipedia that there are exceptions to the hebbian rule, and I was curious about the possibilities of other hypotheses of how learning occur in the brain. So I would like to know: ...