Questions tagged [pharmacology]
Pharmacology is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function
347
questions
-1
votes
0answers
45 views
Do nutrients enter bloodstream via the tongue? [duplicate]
is there any possibility for nutrients to enter the blood stream instantly upon oral administration
1
vote
0answers
20 views
Can a drug induce specific mechanism of resistance in tumors?
For example, can a drug that targets a given protein induce overexpression of that protein or increase the copy number of the gene coding that protein?
I strongly suspect that antineoplastic ...
0
votes
0answers
9 views
Gaba and Magnesium
I read read that magnesium divalent ion binds to gaba receptors and induces the same effects as if gaba has binded. Does anyone know what happens to the gaba that would have been synthesised and ...
2
votes
0answers
20 views
Could Racemic Epinephrine be used to Treat Anaphylaxis? [closed]
To be clear, this question is not a personal health question nor a question seeking health advice, it is only a theoretical question born of a curiosity for the pharmacology and biochemistry of ...
0
votes
1answer
35 views
Does ingestion of alcohol with methylphenidate make it act more like dexmethylphenidate?
Methylphenidate (MPH) is a dopamine and norepinephrine reuptake inhibitor. It is the racemic mixture of d-MPH and l-MPH. According to the binding profile info on Wikipedia, based on studies, it is at ...
-1
votes
1answer
45 views
Why males are more prone to cardiovascular diseases such as heart attacks than females?
I often see more people of males undergoing treatment for heart disease. It is often said that female reproductive hormone (oestrogen) has some cardio-protective action by preventing constriction of ...
1
vote
2answers
48 views
Can a person be infected with Polio even after vaccination in childhood?
We know that a person develops antibodies by active immunisation after the administration of vaccines (either in dead form / live attenuated form). Is there any chance of developing the same disease ...
0
votes
0answers
18 views
Theoretical basis for amphetamine salt combo(Adderall) vs Dextroamphetamine
After re-reading the help questions I think this belongs here as I am more interested in the biochemical motivations rather than any medical query or advice(but may also fit Chemistry SE).
So from ...
5
votes
0answers
24 views
Are there pre-synaptic alpha 2 receptors in the post-ganglionic synapses of the heart?
Are there pre-synaptic alpha 2 receptors in the post-ganglionic synapses of the heart?
I haven't found any sources that clearly state whether they do or not. I'm also not sure if they exist in most ...
1
vote
0answers
10 views
Why do some texts say that noncompetitive antagonist dose no change in ED50 of agonist in Dose-respond curve?
Competitive antagonists increase the ED50 while the Emax remains the same. Non-competitive antagonists do not change the ED50 while decreases the Emax.
I wonder how does this happen as Non-...
2
votes
0answers
39 views
Pharmacokinetics and cell-membrane permeability of Adenosine triphosphate disodium hydrate
【My Question】
(1) Please tell me the pharmacokinetics of this ATP (or Adenosine triphosphate disodium hydrate) when it is administered orally or intravenously. In particular, Does this material has ...
1
vote
1answer
52 views
Difference between “controlled release” vs “prolonged release”
My sister is using the epilepsy drug Tegretol which has both CR and retard (previous naming for prolonged release according to https://www.medicines.org.uk/emc/product/5932/smpc) versions in different ...
1
vote
0answers
23 views
Can you predict what the metabolites of pipradrol would be? Are they similar to those of methylphenidate? [closed]
As these drugs are structurally very similar, I am curious about how the body would handle them. Ritalinic acid is a major metabolite of methylphenidate, but that's about all I know.
Thanks
...
0
votes
0answers
14 views
Presence of anti-drug-antibodies in patients prior to drug exposure (Mabs)?
How do we explain the presence of anti-drug-antibodies in patients prior to exposure to a drug - specifically for monoclonal antibodies (Mabs)?
0
votes
1answer
31 views
Protein inhibitory process
I usually find substances that activates proteins, like ApoA-I, but I don't find substances that inhibit it.
So in an experimental design, could I consider the absence of a drug that directly acts ...
2
votes
0answers
46 views
What's the difference between veterinary and human snake antivenom?
Recently, out of curiosity, I looked online if snake antivenom for humans were actually sold for individuals. I found out they aren't. Not only that, but bills can get really high on countries that ...
1
vote
1answer
53 views
What would happen if VEGF was injected into a person?
Couldn't VEGF help with ligament recovery? I looked it up and found some studies in rats, but nothing on people. VEGF inhibitors tend to be used more often then VEGF.
Why isn't VEGF being used in ...
1
vote
1answer
45 views
Application of molecular dynamics simulation (or alternatives) for the full pathways of protein interactions?
If one would like to control the biological system (e.g. to treat disease or aging/senescence) then one should introduce the drugs in the system, that initiate complex protein interaction pathways ...
1
vote
0answers
30 views
What physiological pathways lie behind inhalants hallucinogenic effect?
I searched through the web and surprisingly I found pretty much nothing on the physiology of hallucinogenic effects of inhalants. Any idea how people get high with inhalants (household and industrial ...
1
vote
1answer
93 views
What exactly does 'reverse use-dependence' mean?
I understand 'use-dependence' related to a drug, for instance, more angiotensin2 effects in a hypertensive more prominent is the action of angiotensin2 receptor blockers. But I do not get the term, '...
6
votes
2answers
250 views
What structural features make a molecule a potent opioid receptor agonist?
For instance, take morphine. It is used as a baseline for measuring the potency of opioid agonists. Its structure looks like this:
But then, take heroin, around three times as potent, its structure ...
2
votes
2answers
65 views
Is it impossible to increase skeletal bone mass, as opposed to just bone density? [closed]
I've heard exercise and resistance/strength training increases the density, but doesn't increase mass. So basically, experimentally or theoretically possible at least, can modern science do this/is it ...
2
votes
0answers
43 views
Could certain drugs enable one to consistently eat above TDEE or BMR without fat gains?
I heard anabolic steroids and stuff like DNP and ephedrine and etc. can somewhat enable one to eat more and get away with it without much or any fat gain, despite eating more than the body would ...
0
votes
0answers
23 views
How are drugs distributed in regards to bone marrow?
I know that as volumes of distribution increase they correspond to the blood, then the vascular rich group (heart, kidneys, liver, brain if BBB permeable), then muscle then adipose. But things like ...
0
votes
0answers
23 views
Why does our body absorb toxic substances or toxic concentrations of a substance if it is capable of regulating gastrointestinal absorption?
Our gastrointestinal system is filled with regulatory molecules that place brakes in the absorption process. For instance, the food that we consume daily is filled with harmful substances that our ...
0
votes
0answers
11 views
Increased receptor occupancy by blocking non-target receptors?
Let's say we have drug X, which is a full agonist at receptor A and a partial agonist at receptor B. We also have drug Y, which has no affinity for receptor A, but is a potent full antagonist at ...
0
votes
1answer
387 views
What is a Archival Tumor Tissue ? For What Purpose is it collected?
Over the course of Conducting trials various tissue and tumor samples are collected from the patients.
One such sample is the Archival Tumor Tissue.
Could someone kindly clarify what is the meaning ...
1
vote
0answers
26 views
Do antimuscarinic drugs increase cAMP or cGMP
Activation of muscarinic receptors M2 and M4 inhibits adenylate cyclase which reduces cAMP levels. It would be expected that antimuscarinics such as ipratropium would increase cAMP levels. However, ...
2
votes
1answer
49 views
How does the body detect irreversible binding to receptors?
I have read an article on Wikipedia about irreversible agonists and antagonists. These permanently bind to a target receptor on a cell. However, the receptor protein is then internalized and recycled ...
1
vote
1answer
63 views
Can (or have) antiviral drugs created drug-resistant viruses?
Evolution/emergence of antibiotic-resistance in bacteria is a known effect of extensive use of pharmaceutical antibiotics.
Pharmaceutical antivirals have come into extensive use in recent decades – e....
1
vote
1answer
52 views
Influenza infections and drug design
Why is the neuraminidase used as a target for drugs against influenza virus instead of haemagglutinin? Is there some basic reason that this will make a more effective drug?
0
votes
0answers
48 views
What is the role of plasminogen used in the preparation of APSAC? (Anisoylated Plasminogen Streptokinase Activator Complex)
What is the role of plasminogen in APSAC, and how is there indirect activation of plasmin through APSAC?
Reference https://www.sciencedirect.com/topics/chemistry/fibrinolytic-agent
2
votes
3answers
182 views
Is reverse senescence/“anti-aging” actually scientifically possible among humans yet?
I have been very interested in this since I myself am interested in reversing my skin's aging/genes/damage/etc. I also am interested in volunteering any future genetic altering of skin quality.
...
1
vote
2answers
114 views
What happens to drug metabolism when CYP450 enzymes are presented with two substrates
What happens when two substances, both substrates for Cytochrome P450 metabolism, are both present in the bloodstream?
For example, with sertraline and cannabidiol (CBD), if someone took a sertraline ...
0
votes
1answer
15 views
Does reversion of resistant strains to wild-type only occur when no more drug pressure is exerted
We always read that wild-type reversion of a resistant strain occurs when no more drug pressure is exerted. Could resistance reversion also occur under drug pressure, but from a drug other than the ...
1
vote
0answers
86 views
How does alcohol interact with sympathomimetics to affect the cardiovascular system?
There is a fair amount of information on the cardiovascular effects of alcohol, and of sympathomimetics. How do they work? And how do their mechanisms interact?
We know that similar pathologies ...
0
votes
0answers
30 views
How does a CRISPR therapy work?
Afaik you can use CRISPR to edit genes of a cell.
But how should therapy for a human work based on CRISPR? Can a drug perform it on vast numbers of ill cells?
1
vote
1answer
35 views
Why are $\beta_2$ receptors present on bronchial smooth muscles , considering that they have only parasympathetic innervation?
It is well known that the bronchial muscles have only parasympathetic innervation. But they still express $\beta_2$ receptors. How does this system still cause bronchial relaxation? What is the exact ...
1
vote
1answer
115 views
What characteristic(s) of inverse agonists allow for inhibitory effects?
I know that inverse agonists have similar structure to its complement agonist; and, as a result, they have the ability to bind to the same receptor, causing an inhibition of the pathway considered.
...
1
vote
1answer
887 views
Why are semi log graphs used in drug Dose response curves?
Why are Dose response curves, as well as most biological graphs shown in semi log graphs and not normal graphs? What is the advantage of semi log graphs over regular graphs? I still haven't gotten an ...
2
votes
1answer
458 views
Why is atropine a CNS stimulant, although it blocks the muscarinic receptors in the brain?
I know that atropine is a muscarinic antagonist, so why does atropine have excitatory actions on the brain while it is blocking muscarinic receptors?
2
votes
0answers
51 views
Hematuria due to Nitric Oxide
Drug interactions between properly dosed NO and other medications are not expected, but side effects may include noisy breathing, hematuria, or possibly atelectasis. (pg.no:577; Goodman and Gilman ...
2
votes
2answers
367 views
Umbrella term for agonist, antagonist, inverse antagonist, etc.
For most receptors there exist different ligands that induce different responses. Depending on the response these different ligands can be classified into different groups such as agonists, ...
1
vote
1answer
42 views
Which kind of drugs get absorbed through epidermis?
Some drugs such as nicotine can be administered through skin. I thought the layers of skin are designed to prevent in-flow of any chemical/germs. Not all drugs get absorbed in this fashion. So do ...
4
votes
2answers
242 views
Humans have Cannabinoid receptors. Does that mean we're meant to consume cannabis?
I know the answer is no. But what then explains the name of these receptors being specific to Cannabinoid found in cannabis? Aren't Cannabinoid receptors exclusive to Cannabinoid? Why are they named ...
3
votes
1answer
424 views
İrreversible dopamine antagonist vs. Dopamine agonist
Can a dopamine agonist reverse the effects of an irreversible dopamine antagonist?
2
votes
1answer
109 views
How long does it take for a blocked dopamine receptor to be broken down by the body?
Do the blocked dopamine receptors get broken down by the body and if so how often ?
In other words how long does it take for the dopamine receptors blocked by irreversible dopamine antagonists to ...
2
votes
0answers
403 views
Why do new atypical antipsychotics like Zyprexa cause TD at lower rates?
When the d2 receptors are blocked for long periods of time they tend to up regulate. This is what causes tardive dyskinesia.
Why do the newer atypical anti psychotics cause such at a lower rate? ...
2
votes
1answer
815 views
Mechanism by which hypokalemia reduces insulin secretion
Is there any known mechanism by which hypokalemia reduces insulin secretion?
This video explains a mechanism, but its inherently wrong because ATP dependent K+ channels will allow movement of K+ from ...
2
votes
1answer
80 views
Is an X ml dose of a drug at 50% bioavailability roughly equivalent to a 2X ml dose at 25% bioavailability?
For the sake of simplicity, assume:
The two doses are the same drug metabolized in the exact same way, and the only difference is the amount that reaches the bloodstream (and thereafter the brain).
...
