Questions tagged [pharmacology]
Pharmacology is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function.
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Decreasing Risks of MAOIs [migrated]
Are MAOIs as dangerous as they are made out to be? I am new to pharmacology, but here is my understanding of MAOIs and antidepressants in general:
There is a presynaptic neuron that stores serotonin ...
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Concentration of active ingredient
For some time now, I have been wondering why, when a tablet is taken, the concentration of active ingredient undergoes an exponential decrease after the maximum concentration value in the blood is ...
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Why does warfarin decrease biological activity of protein C?
Warfarin inhibits VKOR. Hence it disrupts vitamin K dependent $\gamma$-carboxylation of Fc- II, VII, IX, X.
But what exactly it does to Protein C and Protein S? How does it also affect anticoagulant ...
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Can you find the mass of drug X remaining in the body after an oral dose with only bioavailability and half-life?
I'm reviewing this question and think you can't find the answer with the information given.
A patient receives 1g of drug X as a single oral dose. Drug X has a
half-life of 12 hours and an oral ...
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Does one wing of a housefly contain toxins/microbes and the other one antibodies ? (Indonesian university claim) [duplicate]
so recently ı saw this paper but it didn't sound right like how come a flies one wing could have bacterial growth and the other don't. Could someone provide more information about wheter or not this ...
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Does one wing of fly contain harmful microbes and the other contain only antibodies?
There was this study but the conclusion and it's source's relability seemed a bit off. How come a house flies one wing contain all microbe and the other don't.
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What is the purpose of an siRNA screen in drug discovery?
In the paper "A genome-wide siRNA screen identifies a druggable host pathway essential for the Ebola virus life cycle" by Martin et al. the authors try to disrupt the Ebola life-cycle by ...
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Why do molecular generation models maximize “penalized logP” as a measure of drug-likeliness?
I found that Lipinski's rule of five states that Log P (octanol-water partition coefficient, lipophilicity measure) usually should not exceed 5.
Many papers about drug discovery machine learning ...
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Why is the IC50 an interesting measure for in vitro cancer drug screenings?
Large-scale in vitro screenings of (potential) cancer drugs are done to access their effectivity depending on the actual transcriptome of a tumor cell line. Databases like GDSC or CCLE supply data of ...
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Why do animal cells “mistake” rubidium ions for potassium ions?
So, I was browsing the Wikipedia article for rubidium, and came across this interesting tidbit:
Rubidium is not a known nutrient for any living organisms. However, rubidium ions have the same charge ...
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How do prodrugs exactly work? Are there multiple varieties of prodrugs?
I have been reading about a (new?) prodrug of LSD, 1CP-LSD, which is being synthesized in the body to LSD.
However, I don't know how exactly. I read somewhere, that another prodrug of LSD, 1P-LSD was ...
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Does LSD “stay” in your fat storage and then “returns” back?
This rumor was told me by a very anti-drug person. A stance I agree with only lightly.
The rumor was that when you take LSD, it stores itself in your fat storage, and then returns back in 3-6 months, ...
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Could a vaccine injecting B cells theoretically work?
So I was in the car riding to school today when I was struck with genius. Each B cell is attuned to a different pathogen, am I correct? By that logic, would a vaccine injecting a dose of B cells ...
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Are drugs made bitter artificially to prevent being mistaken for candy?
All drugs I remember tasting (with the notable exception of Aspirin) have bitter taste. Is the taste due to the active substance, or is a bittering agent added to them, perhaps to prevent overdose?
...
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Scatchard Plots and Total Receptor Concentration
Im having trouble understanding Scatchard plots.
Y Axis = Bound/Free Ligand
X Axis = Bound Ligand
The graph has a negative slope.
Why when there is almost no Bound (Y axis = 0) do we get a high ...
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How exactly does chemotherapy cause anemia?
I’ve been trying to figure this out for the past few hours but I still can’t find something as in depth as I’m looking for. So far all I’ve found is that chemo drugs kill bone marrow cells and some ...
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What degree of influence do SNPs have on activity of ligands at receptors?
I know that generally, evolution tends to evolve towards having some wiggle room in respect to effect of polymorphisms on binding of endogenous ligands, but with synthetic ligands, especially modern ...
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1answer
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Does GABA enhance or inhibit negative effects of glutamate? [closed]
A study on NCBI studied the correlation between a depressive mood and chronic pain. I researched this because today I noticed unusual emotional volatility as a result of 2 days of acute back pain ...
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Why do beta-1 and beta-2 adrenergic receptors result in two completely different effects (though both use Gs pathway)?
$\beta_2$ adrenergic Receptors are $G_s$-coupled 7-TM proteins. Considering that $G_s$ , by activation increases $[\text{cAMP}]_\text{cytosol}$ which inhibits MLCK of smooth muscles (and causes ...
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Can severe vasoconstriction increase systolic blood pressure?
I know that, vasoconstriction results in increased total peripheral resistance which is responsible for the rise in diastolic blood pressure. Also, cardiac output is responsible for the systolic blood ...
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1answer
43 views
How does noradrenaline result in rise of systolic blood pressure even when the cardiac output is decreasing?
Systolic blood pressure[SBP] depends on the cardiac output. When Nor adrenaline is given there is vasoconstriction due to alpha-1 action on blood vessel, vasoconstriction results in increased total ...
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Is there an antidote for caffeine, e.g. as a supplicant for caffeine-intolerant persons?
First, let me state I'm not talking about a medical emergency. No one is in a serious condition.
My girlfriend is, we think, caffeine-intolerant. She loves the smell of coffee and the habit of coffee ...
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1answer
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Why is prothrombin time used to monitor warfarin and not activated partial thromboplastin time?
Warfarin is said to change prothrombin time (PT) but not activated partial thromboplastin time (aPTT) (for practical purposes at least anyways, not really sure). But looking at the mechanism of action ...
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49 views
Area under the curve in a drug concentration curve
I am not from a background on pharamacokinetics and trying to learn some concepts.
I noticed that the definition for AUC involve the first 24 hours. For example in here AUC is defined as "the area ...
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Same target receptor different mechanism of action?
If different drugs have the same receptor as a target, does that imply that they have the same mechanism of action?
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Why is ACE2 not used as drug against covid? [closed]
Can ACE2 be produced and used as drug against covid? I read it is the receptor molecule. If it is in the organism the virus should bind to it and could not attack cells anymore? Is that right?
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Why do the calicheamicins bind to DNA at the minor, rather than the major, groove?
I am trying to understand why some drugs bind only to the minor groove and not to the major groove. More specifically, I am interested in calicheamicins.
They target DNA and cause strand scission. ...
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how does acetic acid induce pain?
how does acetic acid induce pain? I am finding the whole mechanism of it but cannot find any papers or writings. please help.
If you have links that would be nice too.
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Is this trial that reversed aging in humans worth taking seriously?
In September 2019 Fahy et al. published results from the TRIIM (Thymus Regeneration, Immunorestoration, and Insulin Mitigation) trial. Their stated goals were to investigate whether they could restore ...
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120 views
Do biologists use the word “solubilize” to mean “dissolve”?
I work with biologists who often use the word "solubilize" to mean "dissolve".
Is this correct usage? I keep correcting them (I'm not a biologist, but I help with writing), and we'...
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1answer
40 views
Difference between rate of elimination and clearance? [closed]
I honesty don't get the difference. I need a simple explanation so that I can grasp it.
Rate of elimination is
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Why does plasma protein saturation of a drug increase its volume of distribution and clearance rate?
I need help understanding this statement from Goodman and Gilman's "The Pharmacological Basis of Therapeutics:"
For a drug that is metabolized
by the liver with a low intrinsic clearance-...
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Does the zeta potential of a nanoparticle generally take into account ligand charge?
For example, if I had a quantum dot nanoparticle with conjugated linker peptides capped with polyarginine tracts.
Would the localization of negative charge from arginine change the zeta potential ...
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Is ampicillin a good choice of drug to treat a urinary tract infection caused by E.coli
Is ampicillin a good choice of drug to treat a urinary tract infection (cystitis) caused by E.coli? How does the environment of the urinary tract effect its ability to treat the bacteria.
When ...
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579 views
Why don't anti-viral drugs like “Acyclovir” work against coronaviruses?
I've always used Acyclovir to treat cold sores, why doesn't it work on other viruses?
How do coronaviruses differ from herpesviruses?
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What disposition means in the context of registering clinical studies?
I was diving into the AACT database, and in the studies table I had noticed some columns containing the term disposition such as:
...
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Why is Ibuprofen contraindicated in asthma patients?
So yesterday a patient showed up at the clinic with a massive swelling in his left face region. Upon examination it was found to be due to infected first premolar. Dentist recommended him to get the ...
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1answer
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Does the composition of a meal play a big, or small, role in food's thermogenic effect on the body?
Reading in: "Diet and Health: Implications for Reducing Chronic Disease Risk / Calories: Total Macronutrient Intake, Energy Expenditure, and Net Energy Stores" [NCBI Resources]:
"The thermogenic ...
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Combining MAOIs with Stimulants [closed]
Is it dangerous to combine MAOIs with stimulants? According to wikpedia, Parnate, for example, "leads to an increase in the availability of monoamines, such as serotonin, norepinephrine, and dopamine, ...
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What is “irrational” drug/molecule design?
Both the papers "Directed evolution: the 'rational' basis for 'irrational' design" by Tobin et al. and "Rational and 'Irrational' Design of Proteins and Their Use in Biotechnology" ...
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1answer
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Are omeprazole and other members estrogenic and/or antiandrenergic?
As of 2020, omeprazole is a widely used OTC medicine for various types of acute heartburn and some other gastrointestinal disorders.
Almost every time I read about it I read that one of the possible ...
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1answer
23 views
How exactly can a drug affecting squalene epoxidase affect the methylation cycle, necessitating the use of 5-MTHF?
I found a case report in which the authors say that Terbinafine might have possibly affected the methylation cycle in a patient, necessitating the prescription of 5-methylfolate to correct the ...
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A question about dicumarol
I know that dicumarol was discovered in moldy sweet clover as it caused hemorrhage in cattles, but if someone had thromboembolic disorders causing uncontrolled thrombosis,would it be fine to eat moldy ...
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1answer
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Why is therapeutic index a ratio instead of an interval?
The therapeutic index of a drug is defined as its toxic dose ($TD_{50}$) divided by its effective dose ($ED_{50}$). Why is it defined as a ratio rather than the difference $TD_{50} - ED_{50}$?
For ...
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109 views
What is the difference between Molecular and Cellular tolerance?
Although I've read that there are three types of tolerance, molecular cellular and behavioural, I cannot seem to find any mechanism of cellular other than desensitization of receptors. If someone can ...
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Is PrEP used for anything other than HIV?
In the field of HIV prevention, PrEP is an abbreviation of pre-exposure prophylaxis. This is a very generic term. Are any diseases other than HIV prevented using a similar approach? Do they use the ...
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How does the dopamine spike from drugs compare quantitatively to pleasurable non-drug activities?
I did find this popular press article that quotes a researcher offering the following quantification: "in lab experiments done on animals, sex causes dopamine levels to jump from 100 to 200 units, and ...
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What is the relevance of the constant in the clearance equation?
I have seen the equation for drug half lives described variously as (0.7xVd)/Cl, (0.693xVd)/Cl, and (ln2xVd)/Cl.
What is the origin of this numerical constant in the numerator? What does it signify?
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Is it true that ethanol can have some positive effects?
I recently was reading this inforgrafics about excessive alcohol use. It is written:
No one should begin drinking or drink more frequently based on
potential health benefits
I am surprised. Is ...
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1answer
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Can a drug induce specific mechanism of resistance in tumors?
For example, can a drug that targets a given protein induce overexpression of that protein or increase the copy number of the gene coding that protein?
I strongly suspect that antineoplastic ...
