Questions tagged [prion]

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How many different proteins are able to form prions?

The Wikipedia article on prions and other sources seem to only talk about variants of PrP protein. I think I remember a previous version of Wikipedia saying something about another protein able to ...
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Intelligence of nervous system vs other human intelligence? [closed]

Viral proteins are shown to be used in intelligence such as for memory: https://www.sciencedaily.com/releases/2018/01/180111141450.htm I wondered since proteins able to form prions are the most ...
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Is there any evidence that pancreatic cancer might be caused by an infectious agent?

I'm talking primarily(though perhaps not exclusively) about pancreatic ductal adenocarcinoma(PDAC). I could not find any citations suggesting a viral cause for it but I did find this article ...
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Why there aren't any pandemic diseases by prions?

Learning biology in school, I became interested in the fact that there aren't any diseases by prions which are globally infectious (as far as I know), unlike diseases by viruses (ex. COVID-19, SARS ...
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In terms of Prions is there a possibility, that other proteins apart from PRPC could be misfolded [closed]

This is as from research PRPC seems to be the cause of all Prion related diseases. Thank you
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86 views

Could a virus produce prions, leading to prion disease? [closed]

Viruses can make cells produce proteins that are not a part of the new viruses themselves, but are used to help with replication. However in the case of rotavirus, one of these proteins (NSP4) is ...
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188 views

Are prions a recent biological phenomenon?

Is there evidence to suggest whether prions have existed for a large portion of evolutionary history, played a role in evolutionary history, or could they actually be a recent biological technology ...
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3answers
115 views

Are there any proteins not found in the brain that are affected by prions?

A prion is an abnormally folded protein that is capable of causing otherwise normal proteins to also misfold and become prions. They are responsible for causing diseases such as Kuru and Creutzfeldt–...
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952 views

Difference between prions and amyloid proteins?

Amyloid and prions are misfolded proteins, but what, if any, is the difference between them? Is amyloid a type of prion with a fibrillar structure?
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At what rate does C-BSE occur spontaneously?

BSE is back in the news here in the UK thanks to a new detection in Scotland. I haven't looked into transmissible spongiform encephalopathies much for a decade or so, but as I understand it the ...
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1answer
70 views

How do PrP mutations lead to prion disease?

My understanding is: The PrP gene in human cells is expressed as both PrP-c (normal protein) and PrP-sc (prion disease protein). This happens post transcriptionally, that is, the normal and the ...
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Why do you get prion diseases from eating animal brains but not other parts of the animal?

Eating animal brains is considered a delicacy in parts of China. We know that eating animal brains can lead to prion related diseases. Prions are misfolded proteins that are potentially infectious. ...
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437 views

How do prions cross the blood brain barrier?

How does the PrP scrapie protein maintain its confirmation while going through the GI tract? How does the PrP scrapie protein cross the blood brain barrier? Wouldn't the host immune system recognize ...
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1answer
475 views

What's the difference between prions and prion-like proteins?

If I added a prion domain to a protein, does that make the protein a prion-like protein or would it be considered a prion at that point? I'm trying to understand what prions are, how they aggregate ...
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2k views

Is prion a term used to describe the normal form of the protein as well as the disease causing form?

I've been reading my textbook and it refers to prions as a normal protein with a helpful function but it can turn into a disease causing form. However, I look in my other textbook and it refers to the ...
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Could the denaturation of protein during cooking could generate a prion, by any chance?

It may sound silly, but it appeared to me as a theoretical possibility; not a practical fear. On a healthy and correctly folded protein if cooking process is applied (that includes heating and ...
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1answer
650 views

How does mad cow disease evade immune system? [closed]

The mad cow disease is caused by prions right? So how do prions avoid white blood cells and antibodies?
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What negative effects does cannabalism have in other species (like prion diseases) and how are they mitigated?

It is well known that human cannibals are likely to suffer from a variety of ailments, particularly prion diseases. However a great many other species, from insect to ape practice cannibalism at much ...
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354 views

How do prions transmit their conformation to other proteins?

I was reading about prions and many sources say something to this effect: "Prions may propagate by transmitting their misfolded protein state: When a prion enters a healthy organism, it induces ...
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1answer
692 views

What is the origin of prions?

We know something about the origin of the first cell. But what do we know about prions? How did they originate?
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1answer
145 views

Potential to destroy viruses using prions? [closed]

Could a prion be used to sufficiently deform a viral protein in order to make the virus it is a part of incapable of reproducing? For example, take the common cold's VP1 protein and turn it into a ...
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264 views

How can ingesting a prion "infect" someone?

That's something that's been bugging me for a while... Our gastrointestinal tract produces proteases that degrade proteins. Prions are proteins. Shouldn't they be broken by proteases? Also, how can ...
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1answer
333 views

Can Alzheimer's disease be caused by Slow Prion infection?

I found this claim in my study materials with explanation of amyloi plaques, in comparison to CJD (Creutzfeldt-Jakob Disease). Its characteristic are Long doubling time of at least 5.2 days (I think ...