Questions tagged [recombination]

The process of breaking and recombining strands of DNA.

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Recombinations between Distant coronaviruses

With recombination I mean long ones, say > 1000 nucleotides, so that the two parents must be coronaviruses and the two pieces of genomes must have compatible genomic coordinates for the recombinant ...
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Question about genetic recombination

I am having some difficulty understanding a few things about genetic recombination, in part because of confusion from different diagrams in books. First of all, I wanted to verify whether I have ...
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Are highly-polyploid organisms more resistant to ionising-radiation-induced DNA damage?

Homologous recombination, although most famous for its use to mix together maternal and paternal alleles during meiosis, is most commonly used as a DNA-repair mechanism, allowing cells to repair ...
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How is randomness of the branch migration process ensured?

Branch migration (part of genetic recombination) is a random process. It looks like Ruv-ABC proteins are mainly responsible for this process, but how is randomness ensured? After all, it can only be a ...
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Meiotic recombination hotspots

Im trying to find a proper and general file with chromosomal coordinates for meiotic recombination hotspots. I know that ucsc hgtables, has a table with recombination regions and their recombination ...
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Help with gene linkage and mapping!

Here's an interesting question I've been trying to figure out: My annotations are in red. So far, I've figured out: We know 630 colonies survived when plated with ACD antibiotics...meaning they ...
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chromosome 19 and recombination

Im doing a project with structural variation created by recombination within the human genome during spermatogenesis, where im especially examining intrachromatid homolog recombination. I find that ...
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How is the right amount of nucleotides synthesised during homologous recombination?

I'm reading about homologous recombination in the context of double-strand break repair. It seems like the trick is that around the break, homologous recombination uses a template duplex to generate ...
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Need clarification on Coalescent with Recombination

I've been reading about recombination with coalescent. The link to that file is as follows: http://www.stats.ox.ac.uk/__data/assets/pdf_file/0008/4688/Reading_for_Recombination.pdf I get the part ...
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Is recombination suppressed in the males of all Drosophila species? Any other species?

Following up from this question, I am wondering if the phenomenon of genome-wide suppressed male recombination is limited to Drosophila melanogaster or is common to all Drosophila? The answer to the ...
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QA/monitoring in recombinant vaccine manufacturing

On a16z[0] podcast on vaccines[1], an interesting tidbit came up: vaccine manufacturing in cell cultures is expected to hit a major challenge in terms of quality control due to unpredictable behaviour ...
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Why do genetic testing companies (FTDNA,AncestryDNA,23andme) express DNA shared in centimorgans (cM) instead of in number of base pairs or in percent?

Expressing DNA shared in number of base pairs or in percent of total genome would be so much simpler and easier to understand for the customers. .
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How did the molecular machinery for recombination originate?

I'm wondering about the origins of genetic recombination. During crossover new chromosomes are created. They have different allele combinations from the original two chromosomes. This process allows ...
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Cis and trans linkage

Question: Two dominant non-allelic genes are 50map units apart, the linkage is: (A) Cis type (B) Trans Type (C) Complete (D) Absent/Incomplete My take: After a lot of searching on the net I found ...
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Join a linear plasmid just using a primer (without ligase enzyme)

Can I use just a primer and PCR to join the cutted plasmid like this ? without using any further enzyme like ligase. After the linear dsDNA plasmid annealed into 2 ssDNA, primer will bind to middle. ...
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DNA strand displacement and Branch migration- the same or different or interrelated?

So, recently I have begun studying DNA strand displacement and then I come across the term 'branch migration' (p.s. I am not a biology major student). What I understand is that branch migration is ...