Questions tagged [senescence]

The process of biological aging or the state of an organism being biologically old.

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Why does ageing happen in the human body? [closed]

Cells are continuously renewed all the time as the old cells die and may get recycled by (I believe macrophage ) cells. When mitosis happens to create the new cells, there are many check points in ...
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DNA damage theory of aging and sex

If aging is due to accumulation of damages in DNA, then shouldn't the DNA in gametes also be damaged and so the next generation should be borne old! How does gametes avoid this DNA damage accumulation?...
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Aging: Only humans have grey hair?

I am not sure if I ever saw a monkey or a bird age and lose hair pigment as it grows. It maybe due to my lack of information. But it appears to be a general presumption that only humans age and lose ...
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Is this trial that reversed aging in humans worth taking seriously?

In September 2019 Fahy et al. published results from the TRIIM (Thymus Regeneration, Immunorestoration, and Insulin Mitigation) trial. Their stated goals were to investigate whether they could restore ...
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Why might long telomeres be selected for in laboratory mice?

In a recent episode of The Portal, Eric Weinstein sits down with his brother Bret Weinstein to discuss Bret's Reserve-Capacity Hypothesis. It's an incredible story of scientific discovery and and ...
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Can sleep be a barrier against aging?

I know that what I'm writing about may be a little strange, but as far as I know,when we are asleep, our human body is programmed to carry on biological functionalities in a really optimized way and ...
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What makes learning more difficult as we age?

Why is it harder to adapt yourself to different cultures, places, and languages as you age? What makes breaking up with emotional patterns or ideas after years of habit more difficult? Is there a ...
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Identify brain junk - What are all the known intracellular and extracellular substances which build up with age and clog the brain?

What are the known junk substances which the body is unable to dispose of and which build up in the brain with age to eventually causes age related problems? Starting with the most obvious ones: ...
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Why can't a genetically sound human stay alive for an indefinite amount of time given all the ideal conditions? [duplicate]

I have read that even if we can control our food and lifestyle and keep things as ideal as possible, there are other factors beyond our control like effects from neutrinos passing through our body ...
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Is reverse senescence/“anti-aging” actually scientifically possible among humans yet?

I have been very interested in this since I myself am interested in reversing my skin's aging/genes/damage/etc. I also am interested in volunteering any future genetic altering of skin quality. ...
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What is the longest-lasting protein in a human body?

Protein life times are, on average, not particularly long, on a human life timescale. I was wondering, how old is the oldest protein in a human body? Just to clarify, I mean in terms of seconds/...
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Why do humans lose subcutaneous fat tissue with age?

Why exactly do humans lose subcutaneous fat tissue with age? It appears that we either lose fat cell volume or we might actually be losing the number of fat cells with age. One hypothesis is that as ...
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which of these fields will cure aging? [closed]

life extension is expected to happen as a result of breakthroughs in tissue rejuvenation, stem cells, regenerative medicine, molecular repair, gene therapy, pharmaceuticals, and organ replacement. ...
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Saving lives by “conjoining” people

There are many deaths which occur as a result of a cascade of organ failures triggered by a single event, for example traumatic injuries, severe burns, infections and so on. Since blood transfusion ...
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If senescent cells are removed by the immune system, how can they contribute to ageing?

It is said that senescent cells, also called zombie cells, can cause biological ageing. These senescent cells are also killed by immune cells. It does not make sense as to how they cause ageing if ...
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How are negligibly senescent animals dealing with senescent cell buildup?

Well known animals like the rougheye rockfish, which can be bought from the fish market, appear to be negligily senecent. Senecent cell buildup appears to play a key role in senecence, in mice at ...
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Whitening of hair at old age [duplicate]

Human beings have evolved from their ancestors to their modern forms adapting many changes in structure and I would assume that every change has a significance. So, what is the cause of our hair ...
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What is the average age of my flesh and my bone?

A study reported in the New York Times on August 2, 2005, claims that the average age of all cells in a middle age human is 7-10 years. This was based on new techniques at the time that allowed for ...
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Excercise and fitness in old age [closed]

I have seen so many news and study online, saying exercise keeps body healthy in old age and keeps us fit? how is this possible normal tear and wear will become more with activity hence more mutation ...
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Biomedical consensus on human aging and lifespan [closed]

Medical technology is improving quickly. Unless there is a global disaster and human progress is set back significantly, e.g. by an asteroid or a global nuclear war, there will come a day when humans ...
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Aging and death of perennials

Perennial plants species generate a new plant annually from the same parent root stock. At the end of the year that new shoot withers and dies, to re-appear the next year. Hence, the above-ground ...
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Isn't biological immortality strictly speaking impossible?

This question relates to both immortal cells such as cancers and organisms like the Hydra genus. Isn't it technically impossible for these "immortal" biological systems to live forever, even ...
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Why are the positions of simple sequence repeats at the gene and related transcript sequences different?

I'm working on the simple sequence repeat (SSR). I found just one region (about 21 bp) with an SSR motif in a given gene. This gene has multiple transcripts, with the same SSR motif located in various ...
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If crocodiles are k-selected, why do they supposedly “not age,” as in avoid senescence?

I recently saw a few sources stating that Crocodiles do not biologically age, implying negligible senescence. Basically, a 70 year old crocodile is in the same physical/health condition as a 7 year ...
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Determination of Ageing by ECG inclusions/exclusions?

I am studying ageing and considering ECG signal because of its high sensitivity in theory (escardio). Some factors Sensitivity Gender Medical treatment ... Benchmark: RTG dental + wrist uncertainty ...
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Does the second law of thermodynamics cause aging? [closed]

What is the current understanding as to why organisms age and die? In the following explanation on Ask an Engineer, entropy is not even considered (despite it being answered by an engineer). Unless ...
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Why are cancer rates low in large animals?

Large animals generally have more cells and live longer than smaller animals. For example, bowhead whales live up to 200 years and weigh up to 100 tonnes, as opposed to humans (living ~71 years and ...
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What is the term for being younger than the body age?

I remember that I once attended a seminar in which the speaker talked about the heart rate of different kinds of butterflies. Normally, the heart rate of the adult butterfly will be more complex than ...
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Senescence in space

How is senescence of individual eukaryotic cells and tissues affected by gravity and zero-gravity environments? In other words, can eukaryotic cells live forever in space (given the appropriate ...
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Hydra immortality

Recent research on immortality ha been on an organism named Hydra. I have heard about it being related to some FoxO gene, which has been found in several other organisms but how does telomerase affect ...
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Why the length of UTR in the genomic sequence of gene X is too much longer than the same region in the corresponding Refseq mRNA sequences?

I'm browsing in the UCSC genome browser and found that the UTRs length of KIAA0040 gene in the genomic sequences is too much longer than the corresponding the Refseq mRNA sequence. In fact, the total ...
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Why do people die? [duplicate]

what is the reason people die naturally even though they have no known disease? I see people become physically weak at times they get old and die eventually in case they are not attacked by any known ...
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Do domesticated animals necessarily live longer than wild animals? counterexample wanted!

Generally domesticated animals do not need to worry about their food and other predators, and they have a lower probability of getting sick. However, it seems there is no sharp difference between ...
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Would a person live longer, if such a person lived in a planet with lower gravity? (say, Mars) [closed]

I was wondering: some companies plan to colonize Mars, many of us know. But if one were to live on Mars, would this person live longer? It seems to me that a lower gravity would mean less overall ...
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Do Blanding's Turtles die of old age?

I have recently found articles and various claims that turtles (Blanding's turtles as an exact example) could possibly live indefinitely. http://discovermagazine.com/2002/jun/featturtle This is said ...
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Can plants live forever? [duplicate]

I know that some plants die for old age like a lettuce. But there are trees like Baobabs or larger Ficus in the tropics of whom we don't know their age. And trees like spruce reaching 9950 years old, ...
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What is the role of RAGEs?

According to articles I read, AGEs (advanced glycation end products) activate RAGEs (receptors for AGEs). This activation increases the ROS (reactive oxygen species) levels in the cells. 2003 - ...
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Do all organisms have to die?

I understand (a little) that there are biological clocks and reason that after a certain amount of time organisms die. I'm wondering if that is something inherent in our DNA or in biology/chemistry in ...
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About modern dating techniques

In a comment to this question, it was said that Radiocarbon dating won't work. For a start the tree needs to be dead, which since you're not using the rings I'm assuming it isn't. Also the atomic ...
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How well does the radius of a tree correlate with its age?

I'm looking for a cheap non-invasive ways to approximate the age of a tree (a birch). Measuring the radius pops up in the mind as the first alternative. How would one do that? Measure at multiple ...
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What are senescent cells doing in our bodies? [closed]

I'm reading a paper that mentioned the elimination of senescent cells delays aging. I'd like to receive more information about it. The Baker study published in Nature demonstrates that targeted ...
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Have there been studies done to test Immortality of cancer cells in culture?

This website on cultured cancer cells () says cancer cells may be immortal. I am wondering if there has been any research done to find if cancer cells are really immortal. How old is the still ...
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Known ways to modify the genetic structure of the 13 loci used in CODIS

After reading the answer to Does our DNA change during our lives?, I was wondering if and how it would be possible to change the structure of the 13 loci that are used in the CODIS database, in such a ...
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Do people grow shorter as they age, how common is it, and what triggers it?

Is it true that people become gradually shorter as they age? If it is, is it more common in one gender than the other? And is it known what triggers this? (Considering that the "shortening" probably ...
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Circulating factors affecting human health/longevity

Circulating factors present in young mice have been shown to promote rejuvenation of aged mice, suggesting that tissues have inherent capabilities to regenerate, and circulating factors may be ...
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Can human organs be transplanted indefinitely?

I watched this movie, where they rented hearts to people for a year. I wonder if it is possible to transplant a heart indefinitely from person to person, or does the heart have a lifetime? So, do ...
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What determines the autumn leaf color?

It is autumn out there. Green, brown, red, yellow, and mixed-colored leaves drop from the trees to the ground. What determines the colors of the leaves? Wikipedia tells me Leaf senescence is the ...
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Do couples having children later in life act as an evolutionary mechanism?

Ok, this may be just wild nonsense and I have to warn that my knowledge on the subject is limited. I was reading about how in some countries people choose to have children later in life. After that ...
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Do bacteria die of old age?

I know that the cells of mammals at least stop dividing when they are old, and then die a programmed cell death. Then other cells have to replace them. But in a bacterial colony, each cell ...
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In practice, do fishes die from old age?

I was watching sea birds eating fishes and wondered if fishes actually died from old age, or if they are all eaten before this can happen? I reckon some big predator fishes must be able to live long ...