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Questions tagged [senescence]

The process of biological aging or the state of an organism being biologically old.

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What makes hydra non-aging? [duplicate]

What makes hydra non-aging? Is it stem cells, telomerase, Piwi-piRNA pathway, or something else?
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1answer
88 views

Is reverse senescence/“anti-aging” actually scientifically possible among humans yet?

I have been very interested in this since I myself am interested in reversing my skin's aging/genes/damage/etc. I also am interested in volunteering any future genetic altering of skin quality. ...
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What is the longest-lasting protein in a human body?

Protein life times are, on average, not particularly long, on a human life timescale. I was wondering, how old is the oldest protein in a human body? Just to clarify, I mean in terms of seconds/...
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1answer
312 views

Why do humans lose subcutaneous fat tissue with age?

Why exactly do humans lose subcutaneous fat tissue with age? It appears that we either lose fat cell volume or we might actually be losing the number of fat cells with age. One hypothesis is that as ...
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1answer
72 views

which of these fields will cure aging? [closed]

life extension is expected to happen as a result of breakthroughs in tissue rejuvenation, stem cells, regenerative medicine, molecular repair, gene therapy, pharmaceuticals, and organ replacement. ...
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Does the consistency of Horvath's clock across different tissues suggest anything about aging?

Horvath's clock estimates the chronological age of people based on the methylation of 353 CpG sites. It is noted for its unprecedented accuracy (median error of 3.6 years) and consistency across ...
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1answer
162 views

Saving lives by “conjoining” people

There are many deaths which occur as a result of a cascade of organ failures triggered by a single event, for example traumatic injuries, severe burns, infections and so on. Since blood transfusion ...
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Hi, im trying make a work about Hayflick limit, and I have a question about the DNA replication. [duplicate]

What I do not understand is why in almost the whole literature it is written that the telomere shortening will only be on the lagging chain, although the leading chain at the beginning with the end ...
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1answer
117 views

If senescent cells are removed by the immune system, how can they contribute to ageing?

It is said that senescent cells, also called zombie cells, can cause biological ageing. These senescent cells are also killed by immune cells. It does not make sense as to how they cause ageing if ...
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How are negligibly senescent animals dealing with senescent cell buildup?

Well known animals like the rougheye rockfish, which can be bought from the fish market, appear to be negligily senecent. Senecent cell buildup appears to play a key role in senecence, in mice at ...
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1answer
88 views

Whitening of hair at old age [duplicate]

Human beings have evolved from their ancestors to their modern forms adapting many changes in structure and I would assume that every change has a significance. So, what is the cause of our hair ...
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What is the average age of my flesh and my bone?

A study reported in the New York Times on August 2, 2005, claims that the average age of all cells in a middle age human is 7-10 years. This was based on new techniques at the time that allowed for ...
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1answer
88 views

Excercise and fitness in old age [closed]

I have seen so many news and study online, saying exercise keeps body healthy in old age and keeps us fit? how is this possible normal tear and wear will become more with activity hence more mutation ...
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0answers
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Biomedical consensus on human aging and lifespan [closed]

Medical technology is improving quickly. Unless there is a global disaster and human progress is set back significantly, e.g. by an asteroid or a global nuclear war, there will come a day when humans ...
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1answer
61 views

Aging and death of perennials

Perennial plants species generate a new plant annually from the same parent root stock. At the end of the year that new shoot withers and dies, to re-appear the next year. Hence, the above-ground ...
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2answers
2k views

Isn't biological immortality strictly speaking impossible?

This question relates to both immortal cells such as cancers and organisms like the Hydra genus. Isn't it technically impossible for these "immortal" biological systems to live forever, even ...
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1answer
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Why are the positions of simple sequence repeats at the gene and related transcript sequences different?

I'm working on the simple sequence repeat (SSR). I found just one region (about 21 bp) with an SSR motif in a given gene. This gene has multiple transcripts, with the same SSR motif located in various ...
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1answer
177 views

If crocodiles are k-selected, why do they supposedly “not age,” as in avoid senescence?

I recently saw a few sources stating that Crocodiles do not biologically age, implying negligible senescence. Basically, a 70 year old crocodile is in the same physical/health condition as a 7 year ...
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Determination of Ageing by ECG inclusions/exclusions?

I am studying ageing and considering ECG signal because of its high sensitivity in theory (escardio). Some factors Sensitivity Gender Medical treatment ... Benchmark: RTG dental + wrist uncertainty ...
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1answer
820 views

Does the second law of thermodynamics cause aging? [closed]

What is the current understanding as to why organisms age and die? In the following explanation on Ask an Engineer, entropy is not even considered (despite it being answered by an engineer). Unless ...
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1answer
328 views

Why are cancer rates low in large animals?

Large animals generally have more cells and live longer than smaller animals. For example, bowhead whales live up to 200 years and weigh up to 100 tonnes, as opposed to humans (living ~71 years and ...
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0answers
72 views

What is the term for being younger than the body age?

I remember that I once attended a seminar in which the speaker talked about the heart rate of different kinds of butterflies. Normally, the heart rate of the adult butterfly will be more complex than ...
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0answers
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Senescence in space

How is senescence of individual eukaryotic cells and tissues affected by gravity and zero-gravity environments? In other words, can eukaryotic cells live forever in space (given the appropriate ...
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Hydra immortality

Recent research on immortality ha been on an organism named Hydra. I have heard about it being related to some FoxO gene, which has been found in several other organisms but how does telomerase affect ...
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1answer
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Why the length of UTR in the genomic sequence of gene X is too much longer than the same region in the corresponding Refseq mRNA sequences?

I'm browsing in the UCSC genome browser and found that the UTRs length of KIAA0040 gene in the genomic sequences is too much longer than the corresponding the Refseq mRNA sequence. In fact, the total ...
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0answers
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Why do people die? [duplicate]

what is the reason people die naturally even though they have no known disease? I see people become physically weak at times they get old and die eventually in case they are not attacked by any known ...
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Do domesticated animals necessarily live longer than wild animals? counterexample wanted!

Generally domesticated animals do not need to worry about their food and other predators, and they have a lower probability of getting sick. However, it seems there is no sharp difference between ...
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2answers
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Would a person live longer, if such a person lived in a planet with lower gravity? (say, Mars) [closed]

I was wondering: some companies plan to colonize Mars, many of us know. But if one were to live on Mars, would this person live longer? It seems to me that a lower gravity would mean less overall ...
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1answer
129 views

Do Blanding's Turtles die of old age?

I have recently found articles and various claims that turtles (Blanding's turtles as an exact example) could possibly live indefinitely. http://discovermagazine.com/2002/jun/featturtle This is said ...
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2answers
880 views

Can plants live forever? [duplicate]

I know that some plants die for old age like a lettuce. But there are trees like Baobabs or larger Ficus in the tropics of whom we don't know their age. And trees like spruce reaching 9950 years old, ...
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0answers
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What is the role of RAGEs?

According to articles I read, AGEs (advanced glycation end products) activate RAGEs (receptors for AGEs). This activation increases the ROS (reactive oxygen species) levels in the cells. 2003 - ...
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3answers
4k views

Do all organisms have to die?

I understand (a little) that there are biological clocks and reason that after a certain amount of time organisms die. I'm wondering if that is something inherent in our DNA or in biology/chemistry in ...
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1answer
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About modern dating techniques

In a comment to this question, it was said that Radiocarbon dating won't work. For a start the tree needs to be dead, which since you're not using the rings I'm assuming it isn't. Also the atomic ...
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2answers
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How well does the radius of a tree correlate with its age?

I'm looking for a cheap non-invasive ways to approximate the age of a tree (a birch). Measuring the radius pops up in the mind as the first alternative. How would one do that? Measure at multiple ...
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1answer
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What are senescent cells doing in our bodies? [closed]

I'm reading a paper that mentioned the elimination of senescent cells delays aging. I'd like to receive more information about it. The Baker study published in Nature demonstrates that targeted ...
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3answers
866 views

Have there been studies done to test Immortality of cancer cells in culture?

This website on cultured cancer cells () says cancer cells may be immortal. I am wondering if there has been any research done to find if cancer cells are really immortal. How old is the still ...
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0answers
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Known ways to modify the genetic structure of the 13 loci used in CODIS

After reading the answer to Does our DNA change during our lives?, I was wondering if and how it would be possible to change the structure of the 13 loci that are used in the CODIS database, in such a ...
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1answer
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Do people grow shorter as they age, how common is it, and what triggers it?

Is it true that people become gradually shorter as they age? If it is, is it more common in one gender than the other? And is it known what triggers this? (Considering that the "shortening" probably ...
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1answer
311 views

Circulating factors affecting human health/longevity

Circulating factors present in young mice have been shown to promote rejuvenation of aged mice, suggesting that tissues have inherent capabilities to regenerate, and circulating factors may be ...
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3answers
2k views

Can human organs be transplanted indefinitely?

I watched this movie, where they rented hearts to people for a year. I wonder if it is possible to transplant a heart indefinitely from person to person, or does the heart have a lifetime? So, do ...
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2answers
953 views

What determines the autumn leaf color?

It is autumn out there. Green, brown, red, yellow, and mixed-colored leaves drop from the trees to the ground. What determines the colors of the leaves? Wikipedia tells me Leaf senescence is the ...
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2answers
402 views

Do couples having children later in life act as an evolutionary mechanism?

Ok, this may be just wild nonsense and I have to warn that my knowledge on the subject is limited. I was reading about how in some countries people choose to have children later in life. After that ...
126
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1answer
14k views

Do bacteria die of old age?

I know that the cells of mammals at least stop dividing when they are old, and then die a programmed cell death. Then other cells have to replace them. But in a bacterial colony, each cell ...
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2answers
3k views

In practice, do fishes die from old age?

I was watching sea birds eating fishes and wondered if fishes actually died from old age, or if they are all eaten before this can happen? I reckon some big predator fishes must be able to live long ...
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1answer
297 views

Senescence, immortality and evolution?

Many have heard about the fabled "immortal" jellyfish, Turritopsis dohrnii, which doesn't die from aging (senescence) and can revert the aging process indefinitely. It is rather remarkable that only ...
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0answers
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How can stem cells be counted in body?

In the study of supercentenarian woman here, it was found that all her blood cells are formed from only two stem cells (ancestor stem cells). How scientists can distinguish cell ancestors? Aren't ...
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8answers
10k views

Why does evolution not make our life longer?

Why does evolution not make life longer for humans or any other species? Wouldn't evolution favour a long life?
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2answers
1k views

Does increased physical activity increase the rate of cell division?

Ever since learning that the shortening of telomeres is linked to aging I've tried to figure out what causes cells to divide, and if it's possible to slow down the rate of cell division through life ...
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1answer
136 views

Source of information on the evolution of aging/senescence

Do you know a good review (published peer-reviewed or an online course or whatever) that offers a good overview of all hypothesis explaining the various patterns linked with aging? I'd like this ...
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Effect of Aging on SA node's sympathetic fibers

I am trying to understand the effect of aging on the sympathetic fibers of SA node. I know that aging shifts the vagal curve to left in frequency due to aging. However, I am interested if aging has ...