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Questions tagged [senescence]

The process of biological aging or the state of an organism being biologically old.

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Why does increased age cause degradation?

(I'm not super familiar with biology just curious, so bear with me!) My understanding: As people get older (or are very unhealthy) they have accumulated more "bad habits" than others who are ...
Rookynote's user avatar
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1 answer
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Why do old willows have so many broken limbs?

Willows have a reputation for being very flexible. In a nearby park (PA), where I often walk, there are about 20 willows growing by a stream. Willows over 30' to 40' tall have almost all their major ...
Rich's user avatar
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What causes the activation of "Late acting deleterious genes" in late age but not in young age, whose accumulation causes ageing according to Medawar?

Sir Peter Medawar proposed that aging is the byproduct of "late acting deleterious genes". Evolution is good at weeding out genetic mutations that are harmful at an young age, before the ...
Sanjay Biswas's user avatar
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Does Dr. Sinclair's Epigenome Resetting in ICE Mice Also Repair Telomere Length?"

Dr. Sinclair's team at Harvard University has published a paper this year on rejuvenating ICE mice by reprogramming cells to reset the epigenome. Does this cellular reprogramming also repair the ...
taka kishi's user avatar
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Is there a link between SASP and fibrosis?

1/ Fibrosis: Fibrosis is the formation of excessive fibrous connective tissue in an organ or tissue during a reparative process. 2/ SASP: SASP is the accumulation of molecules and senescent cells in ...
totalMongot's user avatar
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Variance in epigenetic drift rate between different species

My question relates to the prospect of (near?) future control of biological aging. As I understand, it has been recently demonstrated by Prof. David Sinclair's group that epigenetic drift appears to ...
anps's user avatar
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Does your body type affect the rate at which you age

Out of the 3 body types: ectomorph, endomorph and mesomorph, does one age quicker/slower than the others or does it not matter so much? There are many factors that affect the rate of ageing, but I'm ...
Pencilcase's user avatar
2 votes
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In life history theory, does trade-off between reproduction and growth and maintenance imply longer health span for a sexually inactive organism?

The life history theory suggests that there exists trade-off between life processes like reproduction and growth and maintenance of the organism. One significant trade off is between somatic effort (...
ignorant's user avatar
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difference between proximal and distal mechanisms of aging in biogerontology?

In his book Biology of Aging, Roger McDonald describes the difference between causes and mechanisms of aging; and states that the cause of aging is essentially thermodynamic (entropy) and that ...
program's user avatar
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Evolution of Aging according to Weismann

Several authors agree to the fact that August Weismann was the first to propose an explanation to biological aging (Kirkwood and Cremer, 1982; Gems and Partridge, 2013). A lot of hallmarks (and some ...
program's user avatar
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Aging from inception until forming of reproductive elements

Aging from inception until forming of reproductive construct. For example, it takes two months for Spermatogonia to develop. Why is DNA damage over generations not accumulated? I have this study. ...
MrSmith's user avatar
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What is the best method to check for differential gene expression in large dataset? I want to identify aging differentially expressed genes

My data is RNAseq data and I want to know which all genes (which I am looking for) are differentially expressed with age. I have tried the Kruskal-Wallis test and fold change methods. Do you have any ...
Tushar Patel's user avatar
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If aging is caused by "DNA Damage" why is the process of aging generally similar between people?

When I hear the phrase "DNA Damage" I imagine completely random changes in the DNA of a person's cells. If this is the case, then it seems like every person would age differently depending ...
markv12's user avatar
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Evolution at a glacial pace: how does it work? [duplicate]

Some trees are very long-lived, such as the Great Basin Bristlecone Pine and the Giant Sequoia (up to 4,800 years old). How does natural selection and evolution affect such long-lived organisms? ...
cowlinator's user avatar
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Evidence against aging caused by loss of information in genome and epigenome in humans?

After reading Lifespan by David Sinclair I'm curious if there is any evidence against aging being caused by loss of information in genome and epigenome of 3.7*1013 cells in human body. Specifically ...
letter Q's user avatar
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When telomere length is measured, is the method performed on a collection of cells yielding an average?

What are the methods used in measuring telomeres in human or animal subjects? Can it be done on an individual cell? Has the following concern been raised and addressed before: What if there exists a ...
Jack Fleming's user avatar
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DNA damage theory of aging and sex

If aging is due to accumulation of damages in DNA, then shouldn't the DNA in gametes also be damaged and so the next generation should be borne old! How does gametes avoid this DNA damage accumulation?...
MOON's user avatar
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Aging: Only humans have grey hair?

I am not sure if I ever saw a monkey or a bird age and lose hair pigment as it grows. It maybe due to my lack of information. But it appears to be a general presumption that only humans age and lose ...
Martin Medro's user avatar
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Is this trial that reversed aging in humans worth taking seriously?

In September 2019 Fahy et al. published results from the TRIIM (Thymus Regeneration, Immunorestoration, and Insulin Mitigation) trial. Their stated goals were to investigate whether they could restore ...
Theobald Gegenbauer's user avatar
10 votes
1 answer
4k views

Why might long telomeres be selected for in laboratory mice?

In a recent episode of The Portal, Eric Weinstein sits down with his brother Bret Weinstein to discuss Bret's Reserve-Capacity Hypothesis. It's an incredible story of scientific discovery and academic ...
aRockStr's user avatar
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Can sleep be a barrier against aging?

I know that what I'm writing about may be a little strange, but as far as I know,when we are asleep, our human body is programmed to carry on biological functionalities in a really optimized way and ...
jihed gasmi's user avatar
19 votes
2 answers
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What makes learning more difficult as we age?

Why is it harder to adapt yourself to different cultures, places, and languages as you age? What makes breaking up with emotional patterns or ideas after years of habit more difficult? Is there a ...
PbxMan's user avatar
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Identify brain junk - What are all the known intracellular and extracellular substances which build up with age and clog the brain?

What are the known junk substances which the body is unable to dispose of and which build up in the brain with age to eventually causes age related problems? Starting with the most obvious ones: ...
Retardi Grade's user avatar
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Why can't a genetically sound human stay alive for an indefinite amount of time given all the ideal conditions? [duplicate]

I have read that even if we can control our food and lifestyle and keep things as ideal as possible, there are other factors beyond our control like effects from neutrinos passing through our body ...
Martin Medro's user avatar
3 votes
3 answers
405 views

Is reverse senescence/"anti-aging" actually scientifically possible among humans yet?

I have been very interested in this since I myself am interested in reversing my skin's aging/genes/damage/etc. I also am interested in volunteering any future genetic altering of skin quality. ...
Soap Func's user avatar
50 votes
4 answers
9k views

What is the longest-lasting protein in a human body?

Protein life times are, on average, not particularly long, on a human life timescale. I was wondering, how old is the oldest protein in a human body? Just to clarify, I mean in terms of seconds/...
JalfredP's user avatar
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4 votes
2 answers
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Why do humans lose subcutaneous fat tissue with age?

Why exactly do humans lose subcutaneous fat tissue with age? It appears that we either lose fat cell volume or we might actually be losing the number of fat cells with age. One hypothesis is that as ...
user45506's user avatar
-1 votes
1 answer
112 views

which of these fields will cure aging? [closed]

life extension is expected to happen as a result of breakthroughs in tissue rejuvenation, stem cells, regenerative medicine, molecular repair, gene therapy, pharmaceuticals, and organ replacement. ...
raaaay's user avatar
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Saving lives by "conjoining" people

There are many deaths which occur as a result of a cascade of organ failures triggered by a single event, for example traumatic injuries, severe burns, infections and so on. Since blood transfusion ...
JohnEye's user avatar
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If senescent cells are removed by the immune system, how can they contribute to ageing?

It is said that senescent cells, also called zombie cells, can cause biological ageing. These senescent cells are also killed by immune cells. It does not make sense as to how they cause ageing if ...
Orchid Black's user avatar
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How are negligibly senescent animals dealing with senescent cell buildup?

Well known animals like the rougheye rockfish, which can be bought from the fish market, appear to be negligily senecent. Senecent cell buildup appears to play a key role in senecence, in mice at ...
HannesH's user avatar
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2 votes
1 answer
122 views

Whitening of hair at old age [duplicate]

Human beings have evolved from their ancestors to their modern forms adapting many changes in structure and I would assume that every change has a significance. So, what is the cause of our hair ...
Gourab's user avatar
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What is the average age of my flesh and my bone?

A study reported in the New York Times on August 2, 2005, claims that the average age of all cells in a middle age human is 7-10 years. This was based on new techniques at the time that allowed for ...
airhuff's user avatar
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4 votes
1 answer
130 views

Excercise and fitness in old age [closed]

I have seen so many news and study online, saying exercise keeps body healthy in old age and keeps us fit? how is this possible normal tear and wear will become more with activity hence more mutation ...
murmansk's user avatar
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2 votes
0 answers
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Biomedical consensus on human aging and lifespan [closed]

Medical technology is improving quickly. Unless there is a global disaster and human progress is set back significantly, e.g. by an asteroid or a global nuclear war, there will come a day when humans ...
sambajetson's user avatar
1 vote
1 answer
90 views

Aging and death of perennials

Perennial plants species generate a new plant annually from the same parent root stock. At the end of the year that new shoot withers and dies, to re-appear the next year. Hence, the above-ground ...
Abhishek Kanwar's user avatar
7 votes
2 answers
2k views

Isn't biological immortality strictly speaking impossible?

This question relates to both immortal cells such as cancers and organisms like the Hydra genus. Isn't it technically impossible for these "immortal" biological systems to live forever, even ...
Koen vd H's user avatar
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3 votes
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How much does hearing deteriorate with age?

For the average person, what is the lowest volume of a pure tone at each frequency they can hear as a function of age? I know some people lose hearing faster than other people, because they are ...
Timothy's user avatar
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1 vote
1 answer
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Why are the positions of simple sequence repeats at the gene and related transcript sequences different?

I'm working on the simple sequence repeat (SSR). I found just one region (about 21 bp) with an SSR motif in a given gene. This gene has multiple transcripts, with the same SSR motif located in various ...
Mary's user avatar
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3 votes
1 answer
635 views

If crocodiles are k-selected, why do they supposedly "not age," as in avoid senescence?

I recently saw a few sources stating that Crocodiles do not biologically age, implying negligible senescence. Basically, a 70 year old crocodile is in the same physical/health condition as a 7 year ...
Ham Radio's user avatar
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Determination of Ageing by ECG inclusions/exclusions?

I am studying ageing and considering ECG signal because of its high sensitivity in theory (escardio). Some factors Sensitivity Gender Medical treatment ... Benchmark: RTG dental + wrist uncertainty ...
Léo Léopold Hertz 준영's user avatar
1 vote
1 answer
2k views

Does the second law of thermodynamics cause aging? [closed]

What is the current understanding as to why organisms age and die? In the following explanation on Ask an Engineer, entropy is not even considered (despite it being answered by an engineer). Unless ...
imranal's user avatar
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4 votes
1 answer
414 views

Why are cancer rates low in large animals?

Large animals generally have more cells and live longer than smaller animals. For example, bowhead whales live up to 200 years and weigh up to 100 tonnes, as opposed to humans (living ~71 years and ...
Aleksey Belikov's user avatar
-3 votes
1 answer
208 views

What is the term for being younger than the body age?

I remember that I once attended a seminar in which the speaker talked about the heart rate of different kinds of butterflies. Normally, the heart rate of the adult butterfly will be more complex than ...
Ooker's user avatar
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1 vote
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Senescence in space

How is senescence of individual eukaryotic cells and tissues affected by gravity and zero-gravity environments? In other words, can eukaryotic cells live forever in space (given the appropriate ...
TanMath's user avatar
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3 votes
0 answers
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Hydra immortality

Recent research on immortality ha been on an organism named Hydra. I have heard about it being related to some FoxO gene, which has been found in several other organisms but how does telomerase affect ...
TanMath's user avatar
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2 votes
1 answer
113 views

Why the length of UTR in the genomic sequence of gene X is too much longer than the same region in the corresponding Refseq mRNA sequences?

I'm browsing in the UCSC genome browser and found that the UTRs length of KIAA0040 gene in the genomic sequences is too much longer than the corresponding the Refseq mRNA sequence. In fact, the total ...
Mary's user avatar
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4 votes
0 answers
101 views

Why do people die? [duplicate]

what is the reason people die naturally even though they have no known disease? I see people become physically weak at times they get old and die eventually in case they are not attacked by any known ...
Mostafiz Rahman's user avatar
3 votes
0 answers
1k views

Do domesticated animals necessarily live longer than wild animals? counterexample wanted!

Generally domesticated animals do not need to worry about their food and other predators, and they have a lower probability of getting sick. However, it seems there is no sharp difference between ...
questionhang's user avatar
3 votes
2 answers
361 views

Would a person live longer, if such a person lived in a planet with lower gravity? (say, Mars) [closed]

I was wondering: some companies plan to colonize Mars, many of us know. But if one were to live on Mars, would this person live longer? It seems to me that a lower gravity would mean less overall ...
Neri Rocha's user avatar