Questions tagged [senescence]

The process of biological aging or the state of an organism being biologically old.

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Effect of Aging on SA node's sympathetic fibers

I am trying to understand the effect of aging on the sympathetic fibers of SA node. I know that aging shifts the vagal curve to left in frequency due to aging. However, I am interested if aging has ...
Léo Léopold Hertz 준영's user avatar
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Hydra immortality

Recent research on immortality ha been on an organism named Hydra. I have heard about it being related to some FoxO gene, which has been found in several other organisms but how does telomerase affect ...
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Do domesticated animals necessarily live longer than wild animals? counterexample wanted!

Generally domesticated animals do not need to worry about their food and other predators, and they have a lower probability of getting sick. However, it seems there is no sharp difference between ...
questionhang's user avatar
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What is the role of RAGEs?

According to articles I read, AGEs (advanced glycation end products) activate RAGEs (receptors for AGEs). This activation increases the ROS (reactive oxygen species) levels in the cells. 2003 - ...
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How can stem cells be counted in body?

In the study of supercentenarian woman here, it was found that all her blood cells are formed from only two stem cells (ancestor stem cells). How scientists can distinguish cell ancestors? Aren't ...
Suzan Cioc's user avatar
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Is there a link between SASP and fibrosis?

1/ Fibrosis: Fibrosis is the formation of excessive fibrous connective tissue in an organ or tissue during a reparative process. 2/ SASP: SASP is the accumulation of molecules and senescent cells in ...
totalMongot's user avatar
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difference between proximal and distal mechanisms of aging in biogerontology?

In his book Biology of Aging, Roger McDonald describes the difference between causes and mechanisms of aging; and states that the cause of aging is essentially thermodynamic (entropy) and that ...
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Aging from inception until forming of reproductive elements

Aging from inception until forming of reproductive construct. For example, it takes two months for Spermatogonia to develop. Why is DNA damage over generations not accumulated? I have this study. ...
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Is this trial that reversed aging in humans worth taking seriously?

In September 2019 Fahy et al. published results from the TRIIM (Thymus Regeneration, Immunorestoration, and Insulin Mitigation) trial. Their stated goals were to investigate whether they could restore ...
Theobald Gegenbauer's user avatar
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Can sleep be a barrier against aging?

I know that what I'm writing about may be a little strange, but as far as I know,when we are asleep, our human body is programmed to carry on biological functionalities in a really optimized way and ...
jihed gasmi's user avatar
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How are negligibly senescent animals dealing with senescent cell buildup?

Well known animals like the rougheye rockfish, which can be bought from the fish market, appear to be negligily senecent. Senecent cell buildup appears to play a key role in senecence, in mice at ...
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What is the average age of my flesh and my bone?

A study reported in the New York Times on August 2, 2005, claims that the average age of all cells in a middle age human is 7-10 years. This was based on new techniques at the time that allowed for ...
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Senescence in space

How is senescence of individual eukaryotic cells and tissues affected by gravity and zero-gravity environments? In other words, can eukaryotic cells live forever in space (given the appropriate ...
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Known ways to modify the genetic structure of the 13 loci used in CODIS

After reading the answer to Does our DNA change during our lives?, I was wondering if and how it would be possible to change the structure of the 13 loci that are used in the CODIS database, in such a ...
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What is the name of systemic tension of muscles?

I meat a overtrained friend (25 years old) who cannot rest. He has all muscles and most of the skin very tense. He is practising regularly in gym and sleep badly. He moves like a stick figure and has ...
Léo Léopold Hertz 준영's user avatar
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Does Dr. Sinclair's Epigenome Resetting in ICE Mice Also Repair Telomere Length?"

Dr. Sinclair's team at Harvard University has published a paper this year on rejuvenating ICE mice by reprogramming cells to reset the epigenome. Does this cellular reprogramming also repair the ...
taka kishi's user avatar
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Variance in epigenetic drift rate between different species

My question relates to the prospect of (near?) future control of biological aging. As I understand, it has been recently demonstrated by Prof. David Sinclair's group that epigenetic drift appears to ...
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Does your body type affect the rate at which you age

Out of the 3 body types: ectomorph, endomorph and mesomorph, does one age quicker/slower than the others or does it not matter so much? There are many factors that affect the rate of ageing, but I'm ...
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If aging is caused by "DNA Damage" why is the process of aging generally similar between people?

When I hear the phrase "DNA Damage" I imagine completely random changes in the DNA of a person's cells. If this is the case, then it seems like every person would age differently depending ...
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Determination of Ageing by ECG inclusions/exclusions?

I am studying ageing and considering ECG signal because of its high sensitivity in theory (escardio). Some factors Sensitivity Gender Medical treatment ... Benchmark: RTG dental + wrist uncertainty ...
Léo Léopold Hertz 준영's user avatar