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Questions tagged [serotonin]

The monoamine neurotransmitter, serotonin, also referred to by its chemical name 5-hydroxytryptamine (5-HT). It binds to and activates the 5-HT family of receptors.

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Why do classic psychedelics not cause withdrawal, despite high tolerance?

"Classical" psychedelics, such as LSD, DMT, and Mescaline, are serotonin agonists that cause hallucinogenic effects. They are notorious for having rapid tolerance, such that after consuming such ...
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Number of serotonergic neurons in mouse/rat DRN

What is the (approximate) number of serotonergic neurons in the dorsal raphe nucleus (DRN) of mice and rats?
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Link between hypoglycemic events in Type 1 diabetics and clinical anxiety?

I recognize that the scientific community is aware that the chemical stress pathway is mediated by glucocorticoids. The pathway response initializes as a result of some sort of stress (potentially ...
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406 views

Why are so many recreational drugs serotonin 5-HT1A partial agonists?

I found out that many psychoactive drugs partially activate the 5HT1A receptor. Looking at Wikipedia, these include MDMA, LSD, CBD, Psliocybin/Psilocin, amphetamine and various other psychedelics, and ...
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1k views

Is 5-HTP a SSRI?

Can 5-Hydroxytryptophan (oxitriptan) be categorized as selective serotonin reuptake inhibitor (SSRI)? Since they both act on the serotonin pathway and are used to treat depression and other mood ...
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Epigenetics and serotonin?

In this article http://www.nature.com/neuro/journal/v17/n9/full/nn.3778.html it states that Increased promoter methylation of the serotonin transporter gene predicted increased threat related ...
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Serotonin activity with short 5-HTT promotor region and depression

So after reading a few studies (1,2) it seems that a shorter promotor region for the serotonin transport protein may be associated with increased likelihood of developing depression after stressful ...
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Do serotonergic (5-HT2A-mediated) psychedelics elicit stimulant effects?

I know that 5-HT2A partial agonism is the key mechanism of action of serotonergic psychedelics but I also know that some research (e.g. the selective (no activity on any other known receptor sites) 5-...
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169 views

Which Receptors are Involved in the antidepressant effects of SSRIs?

From what I've read the major receptor subtypes involved in the antidepressant effects of SSRIs are: 5-HT1A 5-HT2C 5-HT3 5-HT6 Please cite journal articles to back up your claims, I don't want any ...
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487 views

Do SSRIs downregulate or upregulate the 5-HT3 receptor?

What effect do SSRIs have on the expression of the ligand-gated ion channel, the 5-HT3 receptor?