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Questions tagged [statistics]

The study of the collection, analysis, and interpretation of data.

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13 views

Correlation seen with low billirubin levels but not the gene that causes Gilbert's syndrome

I was reading the following study on associations between bilirubin and CAD (coronary artery disease). They looked at the bilirubin association, and the genes that cause Gilbert's syndrome, which ...
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55 views

Detect differentially expressing cells

I have data (RNA expression values, obtained with in situ hybridization) collected from 1mio human cells. For each cell, I have the expression value of a negative control (non-human RNA) and single-...
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1answer
72 views

Confusion about read counts distribution in RNA-seq

While reading old DESeq paper (Anders and Huber 2010) I came across following line. If reads were independently sampled from a population with given, fixed fractions of genes, the read counts ...
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29 views

Is it scientifically feasible to compare two samples of different sizes, while values in each sample are average numbers?

I want to compare result from my protein docking experiments to various protein structures of the same protein. I have two samples and in Sample 1, I have ...
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2answers
107 views

Why isn't life expectancy normally distributed?

Lots of phenomenon in nature can be plotted onto some sort of normal distribution, and that makes intuitive sense to me (such as human height). Why then, does global human life expectancy drop off so ...
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1answer
58 views

Help on selecting 2 tests - unsure if they are paired or non-paired statistical test

I have data that measures the temperature of flowers and leaves on different plant species. These are the comparisons I am trying to make: Comparing the flower and leaf of the same plant at the same ...
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1answer
41 views

What does “genetic correlations” mean as opposed to just correlations?

I'm reading the paper "Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior". In Fig. 4 shows "Genetic correlations of same-sex sexual behavior with various ...
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17 views

Can anything useful be done with stable isotope data for a single species

This is my first biology question. So I have some stable isotope data on a single species. This data looks similar to the demo data in the siar package for r which looks like this: ...
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54 views

Mammal Statistics about Natural Death Versus Being Killed?

Is there data determining what percentage of mammals die a natural death (disease, old age) and what percentage die due to being killed and/or eaten by other mammals? In watching wildlife ...
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1answer
17 views

Easy Hardy Weinberg Equilibrium [duplicate]

Hi My friend and I get 2 different answers to this question. I would like to know how to calculate the value of q. My friend says that 500/1500=q because there are 500 recessive alleles in the ...
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1answer
29 views

Vegetation Monitoring - Why permanent plots

Why do most vegetation monitoring programs rely on permanent plots? Take the context of a single ecological restoration site, for example. Let's say the variable of interest is cover by plant ...
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34 views

Frequency of nucleotide sequences of specific length in DNA

How frequently would you find the nucleotide sequence GGATATCCGC (5' to 3' direction) by chance in a DNA molecule? On average, how many times do you expect to find a specific 20 nucleotide sequence in ...
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38 views

Identifying statistically significant gene rich and gene poor regions

I am just wondering If there any adapted way of Identifying significant gene rich and gene poor regions in each chromosome for a given genome say mm10?
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21 views

How can I approach this data that has a different total number of results between samples?

I was not sure whether I should post this in Biology Stack Exchange or Math Stack Exchange so I posted it in both. I was planning on doing a small research for my math class (a final project for the ...
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1answer
49 views

Proof of mechanisms and causal relationships in biology [closed]

Statistical methods in biology are strongly encouraged: they are quantifiable, unbiased, and usually the only ones that are accepted as evidence. However, it doesn't seem like the whole picture. Say,...
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508 views

Where are the statistics for vaccine side effects?

My son told me that that during a discussion at school someone mentioned statistics about side effects of vaccines (I assume that the discussion was about standard vaccines in France). The numbers ...
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2answers
50 views

Is there any relationship between the height of a tree and the number of branches emerging from the main stem?

Is there any relationship between the height of a tree and the number of branches emerging from the main stem? I am particular interested in spruce or fir.
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1answer
106 views

Statistical Analysis for Blood Sugar Measurements

I've conducted a lab aimed towards finding the impact of soluble fiber intake on the change in blood sugar levels. Following an 8 hour fast, I had test subjects consume a fixed amount of carbohydrates,...
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1answer
58 views

How to determine the number of parameters in a phylogenetic model?

I want to calculate the AIC for a phylogeny that I inferred via maximum likelihood. To calculate the AIC I need to know the number of parameters in the model. But how do I determine this?
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How many samples to run an association study on B-Cell receptors

We are trying to find biomarkers on the B-Cell receptor VDJ regions. To do this we plan to run Single cell RNA-Seq (using the solution from 10x genomics https://www.10xgenomics.com/solutions/vdj/) to ...
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2answers
57 views

Book about ordination in ecology

This is a question I posted on Cross Validated few weeks ago but no response has been given so far. I am looking for a book that would cover a lot of different ordinations techniques (indirect ...
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72 views

Epidemic threshold on a directed network

I am trying to understand the equations used in a paper (https://www.nature.com/articles/srep00469.pdf) Mainly I'm trying to understand how the epidemic thershold was calculated using the ...
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0answers
35 views

Amount of animals to use for animal trials [closed]

I am working on an independent research project involving animal models. I am unsure how to deterine how many animals (rats) to use for the project. The rats will be injected with different solutions ...
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1answer
40 views

Chart of intra-species genetic diversity across species / phyla?

I am looking for information on how genetic diversity within a species (not between species) differs between taxa. In other words: Is the "spread" in the genetic pool, if measured, for instance, in ...
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51 views

What is a good approximate functional form for an equation relating plant growth to sunlight?

Question is in the title. I've got daily measurements of daily mean shortwave radiation at the surface, and annual measurements of plant growth (some measure, be it height or biomass or something). ...
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1answer
99 views

Why does drinking milk lead to increased fractures?

Milk has always been associated with strong bones due to the high amount of protein and calcium in it. Yet reading it up on wikipedia, A study published in The BMJ that followed more than 45,000 ...
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1answer
52 views

Log-tranformation and GWAS

Before doing any GWAS (genome-wide association study) it is necessary to check for the normality of the phenotypic distribution. If the phenotype is normally distributed only once it is log-...
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1answer
746 views

Calculating CV for intra-assay ELISA

Sorry if this is in the wrong thread. I have to calculate CV for intra-assay ELISA sample OD's. My problem is that i'm finding people are using sample standard deviation in their CV formula, though ...
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1answer
79 views

Is there a statistical analysis test I can perform that will give me a estimate of total population from my own smaller data sets?

Doing my dissertation on the long term trends in moth populations. I am looking at the trends of specific species. Is there a method to obtain an estimate of total population from smaller samples?
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1answer
383 views

Find the length of DNA sequence? [closed]

Given $N=5\times10^3$ and mutation rate is $\mu=10^{-5}$ per site, find the length of a DNA sequence so that the probability of mutation occuring M, is greater or equal than 0.95. Is there a method ...
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1answer
43 views

Recommended reading to quickly get up to speed on infectious diseases

I am in the beginning stages of a capstone project for my master's in Data Science. For various reasons, I have landed on the subject of Clostridium difficile infection. My background is in Computer ...
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1answer
317 views

Book recommendations: biological data analysis/error

I'm working as an undergrad in a tissue culture lab, and I have the most experience with statistics out of everyone in the lab. However, most of the knowledge I have in statistics is from my math ...
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340 views

Distribution of the number of synapses per neuron

There is a mean number of synapses per neuron in the human brain which is not very well known, but is of order 10,000. (Some say, it's about 6,000, other say it's about 50,000.) What is known about ...
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220 views

How to correlate survival probability to gene expression profile?

I am reading up survival analysis of cancer patients and correlating them to gene expression. I came across this tutorial. Its mostly code. So what I still have not been able to understand is how ...
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1answer
30 views

Query regarding calculation of survival analysis

According to this tutorial, for table to find the survival estimates, the square root of the 6th column is multiplied with the 4th column, which is Survival probability. The value that should come for ...
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68 views

Criticism of the significance of fMRI studies [closed]

On the german Wikipedia page on fMRI I read the following "There is some critisism of the basic assumptions and possible insights gained from fMRI studies which is based on a constructive ...
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1answer
72 views

Does pre-operational exercise affect recovery from surgery? Statistical Analysis [closed]

https://www.medicaljournals.se/jrm/content/html/10.2340/16501977-2210 I understand the difference between statistical significance and effect size, but I am having trouble interpreting the data on ...
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40 views

It is correct to construct tree species-based rarefaction curves for birds?

If I register all the species of birds that uses sp1 tree, then, all the species of birds that use sp2 tree, and so on. With this dataset, I can made a rarefaction curve using "number of tree species" ...
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1answer
115 views

Estimation of species range fragmentation

While discussing species distribution patterns along spatial, temporal or functional gradients one often finds a hump shaped species richness pattern. This is well documented in many taxa and spatial ...
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1answer
50 views

How should you choose from the various methods of constrained ordination?

I have a bacterial OTU matrix from various sample points and times. So for each sample I have the sequence counts across the various OTUs that they were assigned to. I also have a corresponding ...
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53 views

In this poisson distribution in olfactory receptor (OR) pseudogenes neutral mutation rate, how is the mean used?

The 2005 paper A comparison of the human and chimpanzee olfactory receptor gene repertoires describes a poisson distribution, with a mean of 0.701 From that mean, how is the gene disruption rate of ...
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2answers
122 views

Mathematics for genetics

What types of mathematics are useful for studying genetics? Of course, statistics is, and I'm guessing set theory and group theory, but anything else? What about ordinary and partial differential ...
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79 views

Should you perform an ordination (such as PCA) of abiotic variables before a Redundancy analysis (RDA)?

I have a dataset of viral 'OTUs' across various sample points from different sites/times. I also have meta-data collected at these same sample points, for things like temperature and the ...
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1answer
168 views

Phylogenetic Independent Contrasts with discrete traits

I understand that PICs are normally only used for continuous traits. However, on this how-to site (https://www.r-phylo.org/wiki/HowTo/Phylogenetic_Independent_Contrasts) there is mention of "Discrete ...
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50 views

Figuring out an honest indicator in intrasexual selection [closed]

In the first picture, the parameter $r$ seems to compare the direction and strength of two variables. In the second picture, $R^2$ seems to describe the variation of proportion of independent and ...
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1answer
951 views

Are all phenotypes normally distributed

Reposting from the stats stackexchange. John Cook, in his blog https://www.johndcook.com/blog/2015/03/09/why-isnt-everything-normally-distributed/, writes that many aren't: Adult heights follow a ...
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1answer
102 views

Don't understand figures in this citizen-science mosquito ID project

The Citizen-based mosquito monitoring system is a Citizen-Science vector tracking project that involves using any of a wide variety of cell phones to capture "sound bites" (sorry!) of mosquitos. These ...
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1answer
64 views

Why does Stereology use Systematic Random Sampling?

I am a student of Neuroscience and in all my textbooks and lecture notes it is written that in Stereology, Systematic random sampling (SRS) is used to obtain sections. Why it's that and not any other ...
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2answers
1k views

What's the proper way to determine whether dose response curves +/- another variable (besides dose) are statistically different?

I have an experiment wherein I measured uptake of a certain molecule into cells when delivered using Carrier A vs Carrier B. In other words, for example, I delivered 1, 2, 3, 4, 8, and 10 nmoles of ...
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259 views

Using Chi-squared analysis to confirm expected phenotypic ratios of offspring

In a recent question the original poster was faced with deciding which ratios to use in a Chi-squared analysis. They were supposed to decide on, "logically", what test-ratio to use. Example question: ...