Questions tagged [statistics]

The study of the collection, analysis, and interpretation of data.

Filter by
Sorted by
Tagged with
3
votes
1answer
181 views

What percentage of individuals infected with COVID-19 don't have symptoms?

There are various statistics estimating mortality of COVID-19 infections, based on how many diagnosed people have died. These numbers are used by various media to extrapolate how many people will die ...
0
votes
0answers
38 views

Which proteins are part of the most different protein complexes?

Let n be the number of different protein complexes (as defined here) that a protein may be a stable part of for a considerable amount of time (and not only transiently). Which proteins have the ...
2
votes
0answers
25 views

Genes and proteins with a significantly inbalanced composition

According to Wikipedia, the median size of a protein-coding gene is 26,288 bp which makes it possible (from statistical considerations) that the nucleotides C, G, A, T appear in roughly equal amounts ...
0
votes
0answers
16 views

How many cells per germ layer are there in the adult human body?

Assuming that all cells in the adult human body derive from stem cells of one of four types (endodermal, mesodermal, ectodermal, and neural), I wonder what the approximate numbers of cells in the ...
1
vote
0answers
14 views

How many metabolites are in the metabolome of (almost) all eucaryotic cells?

Which small biomolecules (up to the size of amino acids) are present in (almost) every eucaryotic cell and thus part of its biochemical network, constantly and inevitably being produced and ...
1
vote
0answers
15 views

Correlation seen with low billirubin levels but not the gene that causes Gilbert's syndrome

I was reading the following study on associations between bilirubin and CAD (coronary artery disease). They looked at the bilirubin association, and the genes that cause Gilbert's syndrome, which ...
2
votes
0answers
57 views

Detect differentially expressing cells

I have data (RNA expression values, obtained with in situ hybridization) collected from 1mio human cells. For each cell, I have the expression value of a negative control (non-human RNA) and single-...
1
vote
1answer
80 views

Confusion about read counts distribution in RNA-seq

While reading old DESeq paper (Anders and Huber 2010) I came across following line. If reads were independently sampled from a population with given, fixed fractions of genes, the read counts ...
0
votes
0answers
31 views

Is it scientifically feasible to compare two samples of different sizes, while values in each sample are average numbers?

I want to compare result from my protein docking experiments to various protein structures of the same protein. I have two samples and in Sample 1, I have ...
0
votes
2answers
116 views

Why isn't life expectancy normally distributed?

Lots of phenomenon in nature can be plotted onto some sort of normal distribution, and that makes intuitive sense to me (such as human height). Why then, does global human life expectancy drop off so ...
-1
votes
1answer
59 views

Help on selecting 2 tests - unsure if they are paired or non-paired statistical test

I have data that measures the temperature of flowers and leaves on different plant species. These are the comparisons I am trying to make: Comparing the flower and leaf of the same plant at the same ...
2
votes
2answers
56 views

What does “genetic correlations” mean as opposed to just correlations?

I'm reading the paper "Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior". In Fig. 4 shows "Genetic correlations of same-sex sexual behavior with various ...
0
votes
0answers
17 views

Can anything useful be done with stable isotope data for a single species

This is my first biology question. So I have some stable isotope data on a single species. This data looks similar to the demo data in the siar package for r which looks like this: ...
0
votes
0answers
54 views

Mammal Statistics about Natural Death Versus Being Killed?

Is there data determining what percentage of mammals die a natural death (disease, old age) and what percentage die due to being killed and/or eaten by other mammals? In watching wildlife ...
0
votes
1answer
19 views

Easy Hardy Weinberg Equilibrium [duplicate]

Hi My friend and I get 2 different answers to this question. I would like to know how to calculate the value of q. My friend says that 500/1500=q because there are 500 recessive alleles in the ...
2
votes
1answer
29 views

Vegetation Monitoring - Why permanent plots

Why do most vegetation monitoring programs rely on permanent plots? Take the context of a single ecological restoration site, for example. Let's say the variable of interest is cover by plant ...
0
votes
0answers
34 views

Frequency of nucleotide sequences of specific length in DNA

How frequently would you find the nucleotide sequence GGATATCCGC (5' to 3' direction) by chance in a DNA molecule? On average, how many times do you expect to find a specific 20 nucleotide sequence in ...
0
votes
1answer
39 views

Identifying statistically significant gene rich and gene poor regions

I am just wondering If there any adapted way of Identifying significant gene rich and gene poor regions in each chromosome for a given genome say mm10?
0
votes
0answers
21 views

How can I approach this data that has a different total number of results between samples?

I was not sure whether I should post this in Biology Stack Exchange or Math Stack Exchange so I posted it in both. I was planning on doing a small research for my math class (a final project for the ...
0
votes
1answer
50 views

Proof of mechanisms and causal relationships in biology [closed]

Statistical methods in biology are strongly encouraged: they are quantifiable, unbiased, and usually the only ones that are accepted as evidence. However, it doesn't seem like the whole picture. Say,...
5
votes
1answer
521 views

Where are the statistics for vaccine side effects?

My son told me that that during a discussion at school someone mentioned statistics about side effects of vaccines (I assume that the discussion was about standard vaccines in France). The numbers ...
1
vote
2answers
50 views

Is there any relationship between the height of a tree and the number of branches emerging from the main stem?

Is there any relationship between the height of a tree and the number of branches emerging from the main stem? I am particular interested in spruce or fir.
0
votes
1answer
112 views

Statistical Analysis for Blood Sugar Measurements

I've conducted a lab aimed towards finding the impact of soluble fiber intake on the change in blood sugar levels. Following an 8 hour fast, I had test subjects consume a fixed amount of carbohydrates,...
1
vote
1answer
61 views

How to determine the number of parameters in a phylogenetic model?

I want to calculate the AIC for a phylogeny that I inferred via maximum likelihood. To calculate the AIC I need to know the number of parameters in the model. But how do I determine this?
1
vote
0answers
20 views

How many samples to run an association study on B-Cell receptors

We are trying to find biomarkers on the B-Cell receptor VDJ regions. To do this we plan to run Single cell RNA-Seq (using the solution from 10x genomics https://www.10xgenomics.com/solutions/vdj/) to ...
2
votes
2answers
58 views

Book about ordination in ecology

This is a question I posted on Cross Validated few weeks ago but no response has been given so far. I am looking for a book that would cover a lot of different ordinations techniques (indirect ...
1
vote
0answers
72 views

Epidemic threshold on a directed network

I am trying to understand the equations used in a paper (https://www.nature.com/articles/srep00469.pdf) Mainly I'm trying to understand how the epidemic thershold was calculated using the ...
2
votes
0answers
35 views

Amount of animals to use for animal trials [closed]

I am working on an independent research project involving animal models. I am unsure how to deterine how many animals (rats) to use for the project. The rats will be injected with different solutions ...
0
votes
1answer
40 views

Chart of intra-species genetic diversity across species / phyla?

I am looking for information on how genetic diversity within a species (not between species) differs between taxa. In other words: Is the "spread" in the genetic pool, if measured, for instance, in ...
4
votes
0answers
51 views

What is a good approximate functional form for an equation relating plant growth to sunlight?

Question is in the title. I've got daily measurements of daily mean shortwave radiation at the surface, and annual measurements of plant growth (some measure, be it height or biomass or something). ...
2
votes
1answer
101 views

Why does drinking milk lead to increased fractures?

Milk has always been associated with strong bones due to the high amount of protein and calcium in it. Yet reading it up on wikipedia, A study published in The BMJ that followed more than 45,000 ...
3
votes
1answer
54 views

Log-tranformation and GWAS

Before doing any GWAS (genome-wide association study) it is necessary to check for the normality of the phenotypic distribution. If the phenotype is normally distributed only once it is log-...
1
vote
1answer
817 views

Calculating CV for intra-assay ELISA

Sorry if this is in the wrong thread. I have to calculate CV for intra-assay ELISA sample OD's. My problem is that i'm finding people are using sample standard deviation in their CV formula, though ...
1
vote
1answer
80 views

Is there a statistical analysis test I can perform that will give me a estimate of total population from my own smaller data sets?

Doing my dissertation on the long term trends in moth populations. I am looking at the trends of specific species. Is there a method to obtain an estimate of total population from smaller samples?
1
vote
1answer
386 views

Find the length of DNA sequence? [closed]

Given $N=5\times10^3$ and mutation rate is $\mu=10^{-5}$ per site, find the length of a DNA sequence so that the probability of mutation occuring M, is greater or equal than 0.95. Is there a method ...
3
votes
1answer
43 views

Recommended reading to quickly get up to speed on infectious diseases

I am in the beginning stages of a capstone project for my master's in Data Science. For various reasons, I have landed on the subject of Clostridium difficile infection. My background is in Computer ...
2
votes
1answer
324 views

Book recommendations: biological data analysis/error

I'm working as an undergrad in a tissue culture lab, and I have the most experience with statistics out of everyone in the lab. However, most of the knowledge I have in statistics is from my math ...
0
votes
0answers
349 views

Distribution of the number of synapses per neuron

There is a mean number of synapses per neuron in the human brain which is not very well known, but is of order 10,000. (Some say, it's about 6,000, other say it's about 50,000.) What is known about ...
1
vote
0answers
224 views

How to correlate survival probability to gene expression profile?

I am reading up survival analysis of cancer patients and correlating them to gene expression. I came across this tutorial. Its mostly code. So what I still have not been able to understand is how ...
0
votes
1answer
30 views

Query regarding calculation of survival analysis

According to this tutorial, for table to find the survival estimates, the square root of the 6th column is multiplied with the 4th column, which is Survival probability. The value that should come for ...
2
votes
0answers
68 views

Criticism of the significance of fMRI studies [closed]

On the german Wikipedia page on fMRI I read the following "There is some critisism of the basic assumptions and possible insights gained from fMRI studies which is based on a constructive ...
0
votes
1answer
72 views

Does pre-operational exercise affect recovery from surgery? Statistical Analysis [closed]

https://www.medicaljournals.se/jrm/content/html/10.2340/16501977-2210 I understand the difference between statistical significance and effect size, but I am having trouble interpreting the data on ...
1
vote
0answers
40 views

It is correct to construct tree species-based rarefaction curves for birds?

If I register all the species of birds that uses sp1 tree, then, all the species of birds that use sp2 tree, and so on. With this dataset, I can made a rarefaction curve using "number of tree species" ...
8
votes
1answer
116 views

Estimation of species range fragmentation

While discussing species distribution patterns along spatial, temporal or functional gradients one often finds a hump shaped species richness pattern. This is well documented in many taxa and spatial ...
2
votes
1answer
52 views

How should you choose from the various methods of constrained ordination?

I have a bacterial OTU matrix from various sample points and times. So for each sample I have the sequence counts across the various OTUs that they were assigned to. I also have a corresponding ...
1
vote
0answers
53 views

In this poisson distribution in olfactory receptor (OR) pseudogenes neutral mutation rate, how is the mean used?

The 2005 paper A comparison of the human and chimpanzee olfactory receptor gene repertoires describes a poisson distribution, with a mean of 0.701 From that mean, how is the gene disruption rate of ...
1
vote
2answers
125 views

Mathematics for genetics

What types of mathematics are useful for studying genetics? Of course, statistics is, and I'm guessing set theory and group theory, but anything else? What about ordinary and partial differential ...
3
votes
0answers
79 views

Should you perform an ordination (such as PCA) of abiotic variables before a Redundancy analysis (RDA)?

I have a dataset of viral 'OTUs' across various sample points from different sites/times. I also have meta-data collected at these same sample points, for things like temperature and the ...
0
votes
1answer
184 views

Phylogenetic Independent Contrasts with discrete traits

I understand that PICs are normally only used for continuous traits. However, on this how-to site (https://www.r-phylo.org/wiki/HowTo/Phylogenetic_Independent_Contrasts) there is mention of "Discrete ...
1
vote
0answers
53 views

Figuring out an honest indicator in intrasexual selection [closed]

In the first picture, the parameter $r$ seems to compare the direction and strength of two variables. In the second picture, $R^2$ seems to describe the variation of proportion of independent and ...