Questions tagged [stem-cells]

Cells which have not fully differentiated yet, i.e. with the potential to develop into other kinds of cells through asymmetric cell division.

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Is there any clinical evidence that PRP or MSC injections help spinal arthritis or disc problems? [migrated]

I'm 40 years old, and remember the years in my youth when stem cells were touted as the great new miracle discovery. And like most promising new discoveries I've seen the press quietly died away and ...
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Meaning of “gene expression heterogeneity” of embryonic stem cells

What does it mean if a gene has a heterogeneous expression? Does it describe the differences of patterns of expression of that particular gene in a population of cells that are identical? The papers I ...
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CML (Chronic Myeloid Leukemia) and blast cell percentage

I'm trying to understand the oncogenesis of CML. I have a question about CFC cells and blast cells. Are those the same? I know that in the chronic phase of CML there is a blast percentage of 1-10% of ...
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How many hematopeietic stem cells (in percentage) does the bone marrow contains?

I've found out that the body marrow of an adult weights about 5% of it's total weight. How much (%) of the bone marrow consists of hematopeietic stem cells and how much consists of other non-...
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Average Amount of normal stem cells in a given organ

I am trying to find an estimate of the amount of normal stem cells in an organ, because I need it as initial conditions for a model to estimate the secondary cancer risk after radiotherapy. I know ...
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What metabolically happens when an egg fuses with the nucleus of a somatic cell

In stem cell biology, it is recognized that embryonic stem cells are transcriptionally inactive for the first 3 days of development. However, during somatic cell nuclear transfer, the nucleus is ...
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Has a beating cardiomyocyte organoid with 'chamber/s' been generated? if not, why?

Commonly artificial organs are generated though stem cell technology. E.g. IPSC-technology. Cardiomyocytes (Heart cells) spontaneously beat and have been used to create organoids. To further define ...
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Are (muscle) satellite cells the same as muscle stem cells?

In terms of muscle: are the terms 'satellite cell' and 'muscle stem cell' interchangeable? That is, are there muscle stem cells that are not satellite cells, or vice versa?
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Mechanism in which HSCs regain stemness in the niche

I'm reading this review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854531/ which cited Schofield, 1978 (https://pubmed.ncbi.nlm.nih.gov/747780/). In the review, it was described in figure 1 that ...
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Difference between stem cell “expansion”, “repopulation”, and “self-renewal”?

From this paper (link:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130805/), I read "Thus G-CSF results in the expansion of phenotypic HSCs in the bone marrow with reduced repopulating activity and ...
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What would happen to organisms if stem cells didn't differentiate?

I've tried to research this online and looked through my textbooks as well. This is something that has been on my mind for a bit. Will it just mean that the organism is more simple? Or would it mean ...
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What do repopulation and expansion mean in stem cell biology?

I was studying a lecture on the effects of cytokines on hematopoiesis, and it uses these two terms often in the context of the effects of regulators on hematopoietic stem cells: All repopulating bone ...
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From stem cells to fully differentiated cells

I'd like to understand better how stem cells produce fully differentiated cells via progenitor cells. I assume the following: Only cells that are not fully differentiated do divide at all. When a ...
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Why does hair turn white but not skin?

From my understanding melanocyte stem cells (McSCs) stop being produced and we have a finite reserve that gets depleted with time. They're at the origin of melanocytes that create hair and skin ...
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question about stem cells

I was reading this paper: https://www.ncbi.nlm.nih.gov/pubmed/26119455 and became confused after this sentence: "The ICM-derived mouse embryonic stem (ES) cells and epiblast-derived human ...
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Confirmation of organoid's character with the respective organ

How can we verify that the Organoid formed from culturing stem cells shows the exact characteristics of the organ it is developed for?
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Why haven't humans been able to make blood producing vats?

There are people in hospitals in life threatening circumstances that need blood packages, and they fully depend on blood donors' blood. With our current technology, we have been able to "persuade" ...
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Why do stem cells injected into muscle become muscle cells?

In this article published in Science Daily, researchers injected teratoma-derived stem cells into mice with muscular dystrophy, and the stem cells regenerated 80% of the lost muscle. But what is the ...
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What cells in mosses behave analogously to mammalian embryonic stem cells?

The Washington Post article Ancient life awakens amid thawing ice caps and permafrost describes the work of Peter Convey, an ecologist with the British Antarctic Survey and his team, and includes a ...
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Why are different mesenchymal stem cells used for articular, auricular, septal nasal and costal chondrocytes?

Why do stem cell researchers use the mesenchymal stem cells shown in the table above for these specific types of chrondrocytes? Can you only use bone marrow to make articular cartilage, or are there ...
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A theoretical ethical dilemma [closed]

For all those who keep in touch with advancements in field of biology iPSCs ought not to be a foreign term. iPSCs are now being used to make organ models to be able to study diseases and how drugs ...
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Stem cells and if they can correct a lack of apoptosis

If a cell ,call it C1 has no functioning apoptosis mechanism could a stem cell somehow be 'induced' to be like C1 , at least have the same genome as C1. Then use this stem cell 'duplicate' to 'restart'...
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Apart from nerve cells and muscle cells, what types of cells do not undergo mitosis in adult man?

Neurons and muscle cells in adult humans do not have the ability to divide by mitosis, so they can not repair themselves and their cell cycle remains in the interphase. I’m looking for more cells with ...
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Is there natural occurrence of induced pluripotency / expression of Yamanaka factors and what is the evolutionary explanation of that?

Is there natural biological processes in which the full (full reprogramming into pluripotent state) or partial (partial reprogramming, stopped before point-of-no-return, preserving the functional ...
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A cure for radiation exposure?

Some of the greatest inventions of my lifetime have been from looking at nature and copying. I found out tadigrades in outer space have the ability to repair their own DNA when exposed to radiation ...
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Lobed Nuclei still count as One nucleus?

Do the Lobed Nuclei of immune cells (such as Megakaryocytes) still count as one nucleus?
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Self Grown Organs

Could a viable organ be partially grown in a test tube then be hooked up to the host in some way until it is large enough to swap it with the bad organ? For example: Could a smaller replacement heart ...
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Are $DCX^{-}PSA-NCAM^{+}$ neurons the result of adult neurogenesis in human being?

A recent study by Sorrells et al. (2018) has stirred a debate whether human being really do have adult neurogenesis in hippocampus or not. In a following paper- Adult hippocampal neurogenesis: a ...
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How do adult differentiated somatic cells divide?

My textbook (which is Biotechnology by David P. Clark) states, when talking about fate-mapping potential stem-cells: "If the marked cell is not a stem cell, the marker will not be passed onto ...
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Are androgenic-anabolic steroids a form of gene editing?

Is taking AAS a form of gene-editing? Steroids alter genes in some way since they allow people to build more muscle than what's naturally possible -- so they sort of "break" natural genetics somehow. ...
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Can I grow unlimited stem cells from limited embryonic stem cells?

If I theoretically extract a few embryonic stem cells from the embryo and cultured in vitro with enough nutrient to grow more cells. How many maximum of stem cells can I get? Do I need to add any ...
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Transplantation of stem cells

During the autologous transplantation of stems cells from bone marrow to produce new blood cells why all the other stem cells other than the one obtained are destroyed?
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Full name for stem cells

So during research, my professor mentioned a type of stem cell, a name that was like 5-6 words long, that can be used to treat diabetes by creating an "artificial organ". That hypothetical organ would ...
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Why are stem cell therapies more preferred (theoretically) over current measures?

i understand that when stem cells are used to treat injuries using induced pluripotent stem cells (IPS), they can prevent the risk of having any tissue rejection and thus, there isn't a need for use ...
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Is that true that plant stem cells can be used in humans?

I was reading an article (which seems very fake to me) on sensitive topics, but there was one astonishing statement: Stem cells are obtained from certain plants that grow all over the world. Once ...
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What is the relationship between induction of cell differentiation and DNA methylation status?

This may sound like a broad question to ask, but I am working on interpreting a review article for my epigenetics course and I'm having trouble reconciling two seemingly contradictory things this ...
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Evolution of leukemia pluripotent short-term cells

I have a problem in understanding the introduction of this paper entitled "Stability and bifurcation in a model for the dynamics of stem-like cells in leukemia under treatment". As I have no ...
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What determines the physical location of differentiated cells in an organism?

Exposition: As a little kid, I always thought of DNA as being a description of how to build an organism. For example a human DNA would have "Add two legs and two arms", a dogs DNA would have ...
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What are the principles of stem cell engineering?

Suppose you want to convert the skin cell into a pluripotent stem cell. I know there are a few genes that were identified for this purpose (a recent Nobel Prize). But apart from finding such genes, it ...
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How does the cell cycle affect stem cell fate?

I keep reading about the stages of the cell cycle affecting stem cell fate, however I do not understand how. After all, any cell will have to pass through the whole of the cell cycle, and go through ...
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How does the Lgr5 receptor contribute to maintaining stemness in the intestine?

I don't understand the connection between Lgr5 receptor and Wnt between Paneth cells and stem cells. And how does this link to the EphB-EprinB inhibition between transit amplifying cells and ...
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Movement of stem cells from mother to fetus

Recent results from J Lee Nelson and colleagues (Sci Am. 2008 Feb;298(2):64-71; available as full text through Google) show that cells from the mother were found in a person aged 46. Logically, these ...
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What are null cells?

My histology textbook says the following: The pluripotential hemopoietic stemm cell (which resembles a lymphocyte) is a member of the null cell population of lymphocytes. It then goes on to add: ...
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What's the difference in roles of GATA-2 and BMI-1 in guiding Hematopietic cells?

I've discovered that hematopoietic cells become lineage-positive (Lin+) and go down the path of becoming lymphoblasts and myeloblasts, and that both BMI-1 and GATA-2 are transcription factors that ...
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Stem Cell Replication

Reading from the internet, I've come across quotes that said stem cells have the potential to replicate indefinitely. However, there are other sources that say cells that are specialised will have ...
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What is going on in these cells?

Here are some pictures of human iPS cells in culture. After several passages, some cells look really weird, can you help me understand what is going on? What am I looking at? What are those blastocyst-...
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Is O4I2 sufficient to reprogram cells (ie induce pluripotency)? [closed]

Is exposure to the chemical O4I2 (ethyl 2-((4-chlorophenyl)amino)-thiazole-4-carboxylate) sufficient to reprogram an adult cell back to pluripotency? They sell this chemical online for pretty cheap. ...
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What is the difference between pluripotent and totipotent cells?

Both develop into specialized cells.Then how are they different?
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Database of time lapse stem cell differentiation

Currently I am working on a project about modelling the social behaviours of embryonic stem cells (or induced pluripotent stem cells). I need a series of time-lapse live cell images which recording ...
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How can one measure the effect of a stem cell's matrix on the progeny of that stem cell?

A number of recent papers that have used hydrogels to alter the ECM of mesenchymal stem cells to quicken their development to cells used specifically for cartilage or really any other type of cell. ...