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Questions tagged [stem-cells]

Cells which have not fully differentiated yet, i.e. with the potential to develop into other kinds of cells through asymmetric cell division.

19 questions with no upvoted or accepted answers
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What metabolically happens when an egg fuses with the nucleus of a somatic cell

In stem cell biology, it is recognized that embryonic stem cells are transcriptionally inactive for the first 3 days of development. However, during somatic cell nuclear transfer, the nucleus is ...
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Database of time lapse stem cell differentiation

Currently I am working on a project about modelling the social behaviours of embryonic stem cells (or induced pluripotent stem cells). I need a series of time-lapse live cell images which recording ...
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Why are different mesenchymal stem cells used for articular, auricular, septal nasal and costal chondrocytes?

Why do stem cell researchers use the mesenchymal stem cells shown in the table above for these specific types of chrondrocytes? Can you only use bone marrow to make articular cartilage, or are there ...
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Myoblasts Formation

Myoblasts arise from mesenchymal stem cells (MSCs), and are precursors to myocytes. In muscles, in the basement membrane, there are also present satellite cells which can divide to generate muscle ...
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How can stem cells be counted in body?

In the study of supercentenarian woman here, it was found that all her blood cells are formed from only two stem cells (ancestor stem cells). How scientists can distinguish cell ancestors? Aren't ...
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Are $DCX^{-}PSA-NCAM^{+}$ neurons the result of adult neurogenesis in human being?

A recent study by Sorrells et al. (2018) has stirred a debate whether human being really do have adult neurogenesis in hippocampus or not. In a following paper- Adult hippocampal neurogenesis: a ...
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How does the Lgr5 receptor contribute to maintaining stemness in the intestine?

I don't understand the connection between Lgr5 receptor and Wnt between Paneth cells and stem cells. And how does this link to the EphB-EprinB inhibition between transit amplifying cells and ...
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35 views

What's the difference in roles of GATA-2 and BMI-1 in guiding Hematopietic cells?

I've discovered that hematopoietic cells become lineage-positive (Lin+) and go down the path of becoming lymphoblasts and myeloblasts, and that both BMI-1 and GATA-2 are transcription factors that ...
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In induced pluripotency experiments, what happens to the cells that do not become pluripotent?

I am new to this topic, so forgive me if my question is naïve. In an induced pluripotency experiment a few transcription factors are overexpressed in somatic cells and as a result a small portion of ...
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How can one measure the effect of a stem cell's matrix on the progeny of that stem cell?

A number of recent papers that have used hydrogels to alter the ECM of mesenchymal stem cells to quicken their development to cells used specifically for cartilage or really any other type of cell. ...
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final control prior to transfecting an expression vector into a mammalian cell?

I have been asked a general question: Once I have cloned a full-length cDNA into an expression vector, what final important control must I do before I transfect this into an embryonic stem cell line? ...
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Comparing Embryonic stem cell and hepatic stem cell

So, currently, I want to compare transcriptome data for liver cell development. I found 2 data sets which start from stem cell, hepatoblast, and then adult cell. The first data set use hepatic stem ...
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Which of these methods is both effective and reliable in elongate muscle and tendon for use in humans: growth factors or stem cell technology

Which method is it the most effective, but also the most reliable for elongating muscle and tendons for clinical trial; using modern growth factor technology or using modern stem cell technology? ...
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from an ageing reproductive stem cell's DNA to baby's “brand new” somatic cells' DNA

On the one hand, somatic cells's DNA age as life goes on, mitosis after mitosis, and that is reflected into reduced telomeres. On the other hand, during life, reproductive stem cells must age too. ...
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Is this a legitimate teratoma for a human pluripotent stem cell assay?

I can't quite make out this teratoma:                            ...
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Why haven't humans been able to make blood producing vats?

There are people in hospitals in life threatening circumstances that need blood packages, and they fully depend on blood donors' blood. With our current technology, we have been able to "persuade" ...
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Dental follicle cells

Are dental follicle progenitor cells and dental follicle precursor cells the same cells or they are two different cell types? Thank you.
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Stem cells therapy for stroke via thecal sac?

According to this video posted below, stem cells for stroke patients can be induced to thecal sack, below the spinal cord. Those stem cells would make their way up to the brain. https://youtu.be/...
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Totipotent stem cells

I came across this question in my book: In terms of types of stem cells, define "totipotent". a. Cell type able to give rise to all cell types including extraembryonic cell lineages b. Cell type ...