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Questions tagged [telomere]

A region of repeating DNA at the end of a chromosome that protects the chromosome from decaying.

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taqman probes to measure telomere length

Has anyone previously used the TaqMan probe 5'-FAM-AGGGTTAGGGTTAGGGTTA-MGB-NFQ-3' (or something similar in terms of targeting TTAGGG), which targets the telomere repeat sequence (TTAGGG), to estimate ...
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Why don't all cells have active telomerase?

If telomere degeneration plays a role in aging, and extending them is biologically possible with telomerase, why isn't it active in all cells? Humans use it in their germ cells, so why not all somatic ...
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What is the status of the telomeres in HeLa cells?

I read several times about the hypothesis, also reported on Wikipedia, that ageing is linked to the length of the telomeres. Each time the chromosomes are duplicated during a cell split the telomeres ...
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Why are telomeres needed to allow DNA replication at the ends of linear chromosomes?

I’m reading Molecular Biology of the Cell by Alberts et. Al and at one point the authors mention the following: We saw earlier that synthesis of the lagging strand at a replication fork must occur ...
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Any reasonable avenues toward extending telomere length for humans?

Is there any biological research progress toward extending the length of telomeres for humans? It seems as though this has seen some moderate success in extending the length of life of mice -- is it ...
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Does Telomere length shortening with age actually cause our cells to age and stop functioning properly?

The human telomere, a simple repeating sequence of six bases, TTAGGG located at the ends of chromosomes (Moyzis et al, 1988) protect them from degeneration, reconstruction, fusion, and loss. It is ...
schizoid_man's user avatar
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Why do immunoglobulin heavy chain genes sit next to the telomere?

I just noticed that IGH genes are the last group of genes at the end of Chromosome 14. Is there a reason / selection pressure to explain why that is? Below is a snapshot of the UCSC genome browser. As ...
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Why do tumours need stem cells, when they can generate their own telomerase?

In the molecular biology of the cell (6th ed), it is stated that: Some cancers seem to be organized in a similar way: they consist of rare cancer stem cells capable of dividing indefinitly, toghether ...
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Are there any barriers to telomere sequencing other than length?

In the comments to an answer on this question, it was noted that long read sequencing methods (e.g., from PacBio or Oxford Nanopore) have largely eliminated repeat-based assembly problems for bacteria....
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When telomere length is measured, is the method performed on a collection of cells yielding an average?

What are the methods used in measuring telomeres in human or animal subjects? Can it be done on an individual cell? Has the following concern been raised and addressed before: What if there exists a ...
Jack Fleming's user avatar
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Why might long telomeres be selected for in laboratory mice?

In a recent episode of The Portal, Eric Weinstein sits down with his brother Bret Weinstein to discuss Bret's Reserve-Capacity Hypothesis. It's an incredible story of scientific discovery and academic ...
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Why did they expect Astronaut Scott Kelley's telomere shortening to accelerate? (they got longer!)

The NPR News article and podcast Scientists Share Results From NASA's Twins Study says: SCOTT KELLY (NASA Astronaut): You know, the symptomatic stuff is fine. I don't have any long-term negative ...
uhoh's user avatar
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What is an "end-to-end fusion" in the context of telomerase? [closed]

Telomerase is said to prevent "end-to-end fusion" of chromosomes. My question is threefold: What is an "end-to-end fusion"? How does Telomerase prevent end-to-end fusions? Why do end-to-end ...
Dianne's user avatar
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Why telomere shortening slowing down cancer?

I am reading Alternative Lengthening of Telomeres in Mammalian Cells, about how telomeres linked to human cancers. Due to the end-replication problem,5,6 the ends of linear chromosomes shorten ...
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Does TA-65 cause cancer?

I heard about this supplement that lengthens telameres, slowing down aging. Does it cause cancer? I can't seem to find any definitive proof either way... https://www.tasciences.com
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What organism has the longest Hayflick Limit?

Assuming I am understanding the concept correctly, Hayflick Limits are reflective of a cells capacity for stable division. Additionally, the Hayflick Limits of various organisms differs. My question ...
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Probabilities of mutations in telomeres?

Frankly I am a programmer, I've been looking at sites like NCBI and others, but couldn't find what I was looking for so if someone can help: Can you give me the probabilities of mutations in ...
Vahagn Tumanyan's user avatar
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Do telomeres appear at just one end of the chromosome?

I have just studied DNA Replication for my Biology Class and I have this question that leaves me stuck, though I have tried to figure it out myself. During telomere replication, I am aware Telomerase ...
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The relationship between the shape of the bacterial DNA and the blocking of replication machinery

I was reading a course about tolemers when I arrived to this phrase : [...] The ends of a linear DNA molecule cannot be replicated by the cellular replication machinery (which may be one reason why ...
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Can telomere length maintenance be an answer to increased life span of human beings?

Telomere shortening may prevent the development of cancer in human aged cells by limiting the number of cell divisions. However, shortening of telomeres impairs immune function and thus might also ...
Fuka26 Eri's user avatar
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Can cancerous cells reach the Hayflick limit?

This may be a stupid question, but I've been wondering. Each time a cell divides, the telomeres on the chromosomes shorten. If this goes on for long enough, the chromosomes will no longer have ...
Sir Cumference's user avatar
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can you tell someone's age from a DNA sample? [duplicate]

So as I understand it telomeres shorten as you age. Working under that assumption.. let's say you were investigating a crime and there was some DNA evidence that had been left behind. Could you ...
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Are nucleotides at the ends of DNA stripped on aging?

I had the following understanding (now after reading a popular science article seeming wrong understanding): DNA in (regular) cells (in human and some other organisms) are protected by telomers. ...
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Hayflick limit and hair or nails

I am not a bio major but I have heard about Telomerese shortening in each cell division which leads aging and cellular death. I also read that Hayflick limit is about the number of divisions a cell ...
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Telomeres and daughter strands

How is the primer present in the daughter, leading strand replaced? I've circled the primer in question. I don't see how this primer can be replaced by DNA polymerase; there is no free 3' end for ...
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Is each generation getting older? [duplicate]

So we know that our sperm and egg cells get set aside relatively early so that they aren't going through unnecessary cell divisions and causing DNA damage or telomere shortening, but since each new ...
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Does the metabolic rate determine how fast the telomeres shorten?

In many papers one can read that telomeres may play an important role in longevity. According to Calado et al.1 the telomeres of mice are much longer than the telomeres of humans. However, mice have ...
mister nobody's user avatar
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1 answer
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Cloning and Telomeres

I read that the length of telomeres in Dolly was shorter, because the DNA was taken from an old sheep. Shorter telomeres may lead to early aging. What is happening now with cloning? Do we use a ...
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About excessive cellular growth

When there is 'excessive' cell growth 'ordered' by the human body in some specific part of the body that is not part of the usual repairing mechanisms, does this cause extra telomere 'shortening' or ...
user128932's user avatar
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281 views

Regarding cancer cells and telomeres

If cancer cells have telomeres are they different than the telomeres in non-cancerous cells? Would cancer cell telomeres be somehow 'set-up' to function almost indefinitely; in other words are 'they' ...
user128932's user avatar
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Regarding cellular self-destruction

I heard and read telomere 'health' or 'length' ( if that's right ) has alot to do with cell 'health'. If telomere 'abilities' are 'restored' to a 'healthier' status then the cell it is in functions as ...
user128932's user avatar
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Association of shorter telomeres with heart disease

From this paper Those with shorter telomeres in blood DNA had poorer survival, attributable in part to a 3.18-fold higher mortality rate from heart disease (95% CI 1(.)36-7.45, p=0.0079), and ...
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What stops telomerase?

The telomerase is an enzyme that adds telomeres. What stops the telomerase from adding too many telomere sequences ? What's the regulating mechanism ?
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2 types of telomerases?

As telomerase works by adding new nucleotides complementary to the RNA it contains, it cannot work for the complementary strand. Say telomerase X has RNA complementary to the 5' to 3' strand it ...
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Telomerase in tetrahymena

In this amazing video, at 26:03 we see this image We now know that the telomerase contains a sequence complementary to the telomere sequence and so is able to do what it is capable of doing in this ...
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How does the telomere repeat sequence vary in Eukaryotes?

Question: How does the telomeric repeating sequence vary in non-vertebrate Eukaryotes? If you know the repeating sequence of a given species I would appreciate hearing it. Background: Telomerase is ...
hello_there_andy's user avatar
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1 answer
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How do mosquitoes maintain telomere length?

While the vast majority of eukaryotic organisms maintain their chromosome ends (telomeres) via telomerase, an enzyme system that generates short, tandem repeats on the ends of chromosomes, other ...
hello_there_andy's user avatar
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Can we define biological age? [duplicate]

How can we define ageing from a biological standpoint without making an appeal to chronological age? Related, but less important, are there any metrics we can use to determine someone's biological ...
stords's user avatar
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4 votes
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Asexual reproduction and Telomeres

Many eukaryotic organisms like yeasts, hydras , planarias, plants etc reproduce asexually. Replication of End of linear DNA pose a limit to the number of cell divisions. My question : Do asexually ...
biogirl's user avatar
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6 votes
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Is solving cancer required in order to avoid aging?

When the telomerase enzyme is not active the telomere shortens every time the cell duplicates leading to a reproductive limit (Hayflicks limit). On one hand this is a believed reason for aging. On the ...
brillout's user avatar
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How much does the Hayflick limit/telomere length vary across taxa and within humans?

Since they seem to be quite connected, I'm curious if anyone knows of research comparing the Hayflick limit (and presumably by extension telomere length) between different taxa. I've heard the ...
single_digit's user avatar
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Telomeres in cloning experiments

In whole animal cloning ( eg. Dolly ) the nucleus is taken from a somatic cell. So isn't shortening of telomeres a problem ?
biogirl's user avatar
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Telomere shortening during replication

It is widely know that each cell cycle during DNA replication some fraction of the telomeres is lost, and this phenomenon is called the end replication problem. Well this is due to the fact that the ...
Katz's user avatar
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6 votes
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Is telomere shortening consistant over consecutive cell divisions from zygote to a differentiated cell?

Considering the complexity of embryogenesis, a temporal referance would be helpful to coordinate the developmental sequences during embryogenesis and fetal development which is to be completed within ...
Ram Manohar M's user avatar
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Telomere elongation methods?

What sort of telomere elongation methods are there currently? Would this stop aging? (edit: No, probably) I couldn't turn up anything good on google. I was thinking that maybe you could sequence ...
CornSmith's user avatar
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Does Blood Loss Shorten Telomeres?

If blood loss necessitates immediate cell division to replace lost cells, does the increase in cell division correlate to shortening of telomeres? Does it further cause the Hayflick Limit to be ...
Angelo's user avatar
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12 votes
1 answer
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How are new people created from the DNA of an aged person. i.e. Why are we young?

The question "why do we age" has been asked numerous times. But why are we young? The cells of the adult human being are an age (time>0), but how can old cells create new cells that are younger than ...
Aaron Schif's user avatar
26 votes
3 answers
12k views

Why is the Hydra Biologically Immortal?

I have heard that the Hydra organism is biologically immortal (later I found that there are more immortal organisms). Now I know that its immortality is related to its telomerase. The thing is that we ...
MySky's user avatar
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Papers linking telomeres and aging [closed]

I'm currently writing a piece of work about telomeres and aging, and wondered if you could share some good papers you've either read or know of.
benjamin's user avatar
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Difference In Telomeres Between A Thale Cress Plant And A Methuselah Tree

From what I have read and understood telomeres cap off how many times a cell can divide before it can no longer divide and that is what causes aging. A thale cress plant apparently has a life cycle ...
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