# Questions tagged [theoretical-biology]

Questions relating to biological theory or theoretical developments that deals with biological processes.

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### Why is there a negative sign before voltage in the gate variable functions of the Hodgkin-Huxley model?

In Hodgkin and Huxley's articles (1952, J. Physiol.; 1990, Bulletin of Mathematical Biology), the gate variables are formulated as In particular, as $V$ increases, $\alpha_n$ decreases and $\beta_n$ ...
• 37
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• 111
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### How do you calculate the time until the steady-state of a drug?

I encountered a mathematically intriguing conundrum, in that it's related to medicine but is centered around mathematics. Suppose drug A has a half-life in the body of 30 hours. The patient takes 40mg ...
33 views

### PCR: From transgene/microgram to cell concentration

I am doing research on CAR T-cell kinetics. The measurement of CAR T-cell concentrations across time is normally carried out with qPCR (see here, Fig. 1). These concentrations are generally reported ...
134 views

### What is the latest estimated probability for the self assembly of a primitive cell? [closed]

Peusner (Concepts in Bioenergetics, 1974) estimated the probability of the self-assembly of a primitive cell as $10^{-254}$. Given how much more we now know about cell biology, what is the latest ...
• 125
1 vote
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### Resources for understanding the basics of cell signaling, gene expression and cell fate determination, for a physics student?

I'm a physics student who will join a theoretical biology/applied mathematics research group this September. I'll link some papers at the end for further context. The main problem I have is that my ...
• 119
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### Finding population dynamics models for multi-generational species evolution with delays

I am working on a problem from economics, to understand how populations evolve within business organizations. I have found that some of the population dynamics literature is very relevant to my own ...
• 173
284 views

### Examples of bifurcations in real-life systems

Does period-doubling bifurcation and Neimark-Sacker bifurcation happen in real-life systems? Are there some examples? I'm particularly interested in biological host-parasitoid and predator-prey models....
• 123
1 vote
252 views

### What could be a refuge in host-parasitoid models

I was reading about refuge effect in host-parasitoid models and I found somewhere that refuge does not have to be only a place in habitat where hosts can hide, but also some "situation" ...
• 125
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### Ecosystem Control Theory

I've used EcoNet online tool to analyze an ecosystem. You can run the default model by pressing "run model" in order to follow my question. Among the extended results there are 2 'Control ...
• 221
4k views

### Why don't viruses reach broad concentration outdoors in a city like allergens?

Why don't airborne viruses reach concentrations that infect most people vulnerable outdoors in a city the way an allergen can cause inflammation to everyone sensitive to it. Both are (often) ...
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### How does genetic feedback shape the evolution of whole ecosystems?

While looking into the organization of ecosystems and how evolution shapes it, I've been reading "Ecology" (1975) by Eugene Odum. In chapter 6, p. 167, Odum speaks about the mutualistic ...
I am trying to solve for $\text{cov}(w_i,z_i)+E(w_i\Delta z_i)$ as it apears in Price Equations in terms of the mean $\overline{w}$ and variance $\sigma_{w}^2$ of the fitness of a population where I ...