Skip to main content

Questions tagged [tuberculosis]

Tuberculosis is a disease caused by the bacterium Mycobacterium tuberculosis. It infects mainly the lungs, but can be found in other parts of the body. Untreated tuberculosis ends fatal.

Filter by
Sorted by
Tagged with
1 vote
0 answers

Why doesn't repeated Mantaux testing for Mycobacterium tuberculosis cause an immune response?

I have never had TB but have had multiple TB tests for work. All negative. If you are introducing TB antigen with each test, why isn't a memory of that formed by the adaptive immune system?
Joe's user avatar
  • 379
1 vote
0 answers

What is a proper software to do GWAS analysis of tuberculosiis VCFs and phenotype data?

What is a proper software to do GWAS analysis of tuberculosis VCFs and phenotype data? Need a software which will accept VCF file and phenotype data as an input and produce genome wide association ...
player777's user avatar
  • 111
6 votes
1 answer

How is TB harmful in HIV patients?

The mycobacterium of TB doesn't secrete any toxins. The cause of disease in the immunocompetent is the collateral damage due to the immune response against disseminated infection. But then, when HIV ...
Polisetty's user avatar
  • 3,687
22 votes
3 answers

Why are vaccines for polio taken orally while vaccines for TB need to be injected?

My thoughts are that maybe the TB antigens necessary to produce an immune response are proteins; therefore they can be digested in the stomach and small intestine. But I may be wrong though. I am ...
James's user avatar
  • 365
0 votes
1 answer

Geographical distribution of malaria and tuberculosis

Unlike malaria, tuberculosis (TB) is found across the whole world. Why and explain? I mean why are people affected with TB more than malaria and some say that in cold and developed countries malaria ...
Manu's user avatar
  • 1
3 votes
1 answer

Is disease transmisson through milk consumption or meat consumption considered direct or indirect transmission route?

From an epidemiological point of view, is consumption of raw milk or meat considered as indirect or direct transmission ? Let's take the example of bovine TB. Is consumption of unpasteurized milk ...
Cobactan's user avatar
  • 243
19 votes
4 answers

Where’s the flaw in my proposed TB Treatment?

Ten years ago, I emailed a prominent lung specialist with my suggestion for a treatment for Tuberculosis. His lack of response led me to believe that the idea had no merit whatsoever – but I had no ...
Lefty's user avatar
  • 351
0 votes
1 answer

How to do a whole genome analysis of Multidrug-resistant Mycobacterium tuberculosis

I'm looking for tutorials and software that can help me study whole genome sequence data is and genome wide associations. I have Matlab and Bioconductor R so anything involving those packages would be ...
VassiaAlk's user avatar
  • 241
6 votes
1 answer

What (if anything) about tuberculosis makes producing a highly effective vaccine difficult?

What about tuberculosis makes it difficult to produce a safe vaccine that is effective at producing an immunogenic response in >99% of individuals against all strains of the bacteria? I am aware of ...
Deets McGeets's user avatar
3 votes
2 answers

TB disease - treatment and infection

Background: I'm currently performing research in mathematical biology, specifically on the treatment dynamics of HIV and TB co-infection. Question: Can a person infected with TB disease, who are ...
user avatar
1 vote
1 answer

Why PPD test in patients without M.tuberculosis often slightly positive?

I got this question which I interpret as Why PPD test in patients without M. tuberculosis often have slightly positive PPD reaction i.e., a lifelong slightly positive skin test reaction? because ...
Léo Léopold Hertz 준영's user avatar
2 votes
3 answers

Why HIV patients have greater virulence of M.tuberculosis?

I am reading Murray Microbiology book. Some facts M. tuberculosis is an intracellular pathogen. At the time of exposure, M. tuberculosis enters the respiratory airways and infectious particles ...
Léo Léopold Hertz 준영's user avatar
1 vote
0 answers

What are the characteristic structures of bacillus M. tuberculosis and what they cause?

I answered to this question: In most forms of the disease, the bacillus M. tuberculosis spreads slowly and widely in the lungs, causing the formation of hard nodules (tubercles) in the ...
Léo Léopold Hertz 준영's user avatar
1 vote
1 answer

Can acid-fast M. tubercolosis obstruct alveoli?

I am not sure which word is the best here for colonisation of alveoli by acid fast-mycobacteria. I found this question, and I am getting confused by the term obstruction of alveoli because I tend to ...
Léo Léopold Hertz 준영's user avatar