Questions tagged [vaccine]

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Immunological effects - and concerns - regarding m-RNA vaccines? [duplicate]

A study (SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro) claiming that COVID-19 spike protein can enter the nucleus and inhibit DNA damage repair has gone viral. ...
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If we introduce the body with an adjuvant and after a time T with inactivated virus, for what rough reasonable value of T will the vaccine still work?

My understanding is that along with introducing an inactivated virus to the body, we also need to stimulate the immune system using an adjuvant so that there is a strong response to the virus ...
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How much of TLR 7 agonist is safe for human beings, as it is both linked to development of autoimmune diseases but is also used as Vaccine adjuvant?

This question is motivated by the fact that TLR 7 agonists have been linked to development and acceleration of Lupus-like disease both in animals and human beings. But at the same time, TLR 7 agonist ...
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Do spike-protein-based vaccines undermine the DNA repair system?

I ain't no biologist, but I came across a paper recently and tried to understand it: SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro My question: Is it a correct ...
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Is it possible to make a vaccine against cancer?

If we can make RNA vaccines against COVID-19 and we know which errors in our DNA leads to different kinds of cancer, can we make a vaccine that will teach our immune system to detect and destroy ...
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Evolutionary pressure of vaccines towards a virus

I am trying to understand the following quote from one of the Twitter threads : A change in the spike protein which allows the coronavirus to enter and infect human cells that is radical enough to ...
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4answers
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How do mRNA vaccines work with respect to presentation of the antigen?

As I understand it, mRNA vaccines operate by taking a gene for some distinctive feature of the target virus and arranging for the cells of the vaccine recipient to manufacture the proteins that make ...
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Is the covid-19 vaccine-induced copy of the protein spike also damaging cells?

In recent scientific articles, it has been discovered how the spike protein not only is a respiratory disease but also damages blood vessels cells directly, and is connected with higher risk of ...
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Boost of Janssen COVID-19 Vaccine increasing Immune Response to Vector

I have been looking for published, or even pre-print, data that evaluates the serological response to a boost of the Janssen COVID-19 Vaccine against the adenoviral vector Ad26 rather than the ...
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CCTV cameras in Microbiology (Pathology) Laboratories

Isn't it highly beneficial to have CCTV cameras installed in all Microbiology Labs in the COVID-19 times? As the COVID vaccines are already developed, the research & development carried further in ...
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Antibody detection - infection-induced vs vaccine-induced - is it common (or not) for a test to be positive for both?

Given a pathogen and a corresponding vaccine, and given an immune response to either one that results in antibody creation, would it be expected that a clinical test or assay for said antibodies would ...
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Does stronger reaction to vaccine (fever, days of nausea) mean that an immune system would have reacted the same to the virus?

I have heard that the real danger of Covid-19 is the strong immune response. Is it more likely that a person's immune system would have reacted dangerously to the virus?
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Safety of Covid-19 vaccine for pregnant women

Is there any possibility that the protein produced by COVID-19 mRNA vaccine taken into body could cause negative effect for unborn babies? In particular, isn't it possible the protein could be used as ...
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Viral vector vaccines - why doesn't the viral vector get attacked by the innate immune system?

I've been looking at how the Astrazeneca Covid-19 vaccine works: A chimpanzee adenovirus (the viral vector) is injected into the patient. After entering a cell, the viral DNA is deposited in the host ...
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Ingredients in Pfizer vaccine

The ingredients in the Pfizer vaccine have been listed in a number of websites, including government healthcare ones. This site claims that the list includes ALL of the ingredients of the vaccine. ...
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1answer
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How many mRNA strands are in a single dose of the COVID-19 vaccines?

I realize there are several different mRNA vaccines. I would be happy to know the ballpark figure for any of them. As a follow-up, is it known about what percentage of injected mRNA strands are ...
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How long after taking a vaccine shot (Oxford–AstraZeneca) could an individual test negative for antibody (IgM)?

What I know so far about the way this vaccine works is that by encoding virus' biological signature into the vaccine and injecting it into a subject, the subject's immune system would learn to ...
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Understanding mRNA vaccine for COVID

As I've learned, mRNA helps us to produce virus spikes proteins to induce learning of the immune system. But then, I remember to have read that the coronavirus has some trick to pretend to be "...
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Are the antibodies developed by differing vaccines still the same?

If one person gets an mRNA vaccine that teaches their body to deal with a specific virus, and another person gets a similar but different mRNA vaccine, and another person gets a more "classic&...
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If the IAVI G001 HIV vaccine proves itself, why would it work?

The IAVI G001 HIV vaccine trial looks promising. If it works, will it work by preventing a single cell from being infected, or by allowing the body to attack infected cells? What I'm trying to ...
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Can the spike protein created by the Covid mRNA vaccines be created independently of the human body, and is there a higher cost to that?

How different in principle is using the bodies own mRNA to create the coronavirus spike protein differ from other methods of using genes to manufacture other drugs or proteins and is there a cost ...