TL, DR: ----- *Extracellular calcium ions’ “source” are probably cells called **astrocytes** that connect to both neurons and blood vessels.* Calcium ions outside the pre-synaptic neuron are high in concentration, but since they are polar molecules they cannot passively diffuse in, where they are low in concentration, so they stay stuck outside the neuron. Voltage-gated calcium ion channels are closed at rest. These channels will open when depolarization occurs, as the membrane reaches a high-enough voltage threshold. Calcium ions rush in when these channels open. *These **voltage-gated channels are the primary regulator of calcium ion pre-synaptic neuron influx.*** Calcium ions, once inside the neuron, will be used to release neurotransmitters into synaptic cleft. ## The Long-Winded Answer ## > What determines the influx of calcium ions in these channels? Whenever dealing with flux, it’s helpful to start with what determines the flux rate of anything: Rate of flux ∝ gradient / resistance The calcium ion (Ca2+) `gradient` is established by an extracellular concentration > intracellular concentration (at rest) across the neuron’s cellular membrane at the terminal end (pre-synaptic neuron). Le Chatelier’s Principle (equilibrium) indicates that potential energy will build from the unresolved Ca2+ gradient, which will drive flux from high to low when given the chance. The Ca2+ `resistance` is established (mainly) by voltage-gated Ca2+ (VG-Ca2+) channels. These are also on the terminal end of the neuron (pre-synaptic), and resistance is determined specifically on if channels are open or closed (closed at rest), AND the number of VG-Ca2+ channels present on the membrane. To create an influx, gradient has to become > than resistance. Once an action potential travels down the axon and depolarization occurs at our local site, the increase in membrane potential (voltage) opens the VG-Ca2+ channels, thus *decreasing resistance*. Influx of Ca2+ into the axon terminal occurs. ---------- > Where are the ions coming from and what is their source? Neurons are the flashy & exciting (no pun intended) cells in the nervous system, but to answer this question we must acknowledge that **glial cells** exist. **Neuroglia, glia, or glial cells** are cells that DO NOT produce electrical impulses, but are cells within the nervous system. One type of glial cells are called **astrocytes, or astroglia**, and a couple of their many functions includes distributing nutrients to nervous tissue, and *maintenance of (neuronal) extracellular ion concentrations*, including Ca2+. Astrocytes also have access to blood vessels, giving them access to nutrients (supposedly like calcium ions). Research on the specifics is very up-and-coming, so it is difficult to find much on it. We know calcium is coming from blood (crossing the blood-brain barrier), glial networks (including astrocytes) distribute nutrients, and astrocytes specifically are tied to extracellular neuronal ion homeostasis. *If you are interested in researching this further, the connection (and network) of a neuron to its blood supply is called **neurovascular coupling**.* [![Neurovascular coupling][1]][1] *Image: a neurovascular coupling* ---------- > Is the influx determined by the source by changing the ion flow, or the ion flow is constant and the influx of ions into the synapse is only regulated by opening/closing of the channels? Ion flow from source is fairly constant (in a healthy individual), the biggest regulator of ion flux into the pre-synaptic neuron will be the actual VG-Ca2+ channels. Ca2+ outside of the (pre-synaptic) neuron’s axon terminal will influx *when depolarization reaches the axon terminal*, as that decreases Ca2+ resistance across the membrane: 1. Action potential travels down axon 2. Depolarization occurs at axon terminal 3. Increase in membrane potential (voltage) 4. VG-Ca2+ channels open 5. Ca2+ flux down its electrochemical gradient (influx, pre-synaptic neuron) Ca2+, once inside axon terminal, interacts with SNAP and SNARE proteins to shuttle vesicles containing neurotransmitters to the synaptic cleft (Ca2+ - regulated exocytosis). ---------- **Sources** - [Image][2] - [University of Texas: Astrocytes][3] - [Astrocytes-Endothelial Reactions at the Blood-Brain Barrier][4] - [Wikipedia: Astrocytes][5] [1]: https://i.sstatic.net/aXhg1.jpg [2]: https://jonlieffmd.com/blog/the-limits-of-current-neuroscience [3]: https://synapseweb.clm.utexas.edu/astrocytes [4]: https://www.nature.com/articles/nrn1824/#Fig5 [5]: https://en.wikipedia.org/wiki/Astrocyte?wprov=sfti1