[Crick’s Central Dogma](https://profiles.nlm.nih.gov/ps/access/SCBBZY.pdf) was actually: >*The Central Dogma*<br> This states that once ‘information’ has passed into protein it cannot get out again. In more detail, **the transfer of information from nucleic acid to nucleic acid, or from nucleic acid to protein may be possible, but transfer from protein to protein, or from protein to nucleic acid is impossible**. Information means here the precise determination of sequence, either of basesin the nucleic acid or of amino acid residues in the protein. So, although in my comment I stated that the discovery of [reverse transcriptase](http://basic.shsmu.edu.cn/jpkc/cellbiota/resource/exper/19.pdf) was the first violation of this — as was generally regarded — this turns out not to be the case. (It was felt to be different from the existence of RNA viruses because it involved RNA to DNA, which were generally represented by a unidirectional arrow in the opposite direction in diagrams of the dogma.) And, so the central dogma has never been violated (certainly not by lncRNAs), unless you consider [prions](https://en.wikipedia.org/wiki/Prion), where information of sorts is transfered from protein to protein. Hmm, never thought of it like that before.