Databases like STRING have so many predicted as well as experimental interactions data for many organisms.However there is a bias in the data which they have?.
>a)The first is gene co-occurrence  which is more like a circular argument.

>b)And the second one is all interactions that are predicted computationally are tested for experimental interactions.This leads to a bias in the interaction data available for organisms in STRING.

How do we overcome this data bias while using STRING interaction data for analysis purpose?
>a)Avoiding evidence channels of gene co-occurrence is one way.Is there any other way other than this?

>b)How to statistically say that the bias is not governing the data or any way to test statistical significance of the data bias?