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The study of the molecular structure of biological macromolecules and how that structure relates to their function.

2 votes
1 answer
264 views

Are there known 3- or 4-nucleotide RNA linkers with no RE sites?

Question is rather self-explanatory. I'm looking for a non-cleavable RNA sequence to act as an RNA linker. I mention 3- or 4-nucleotides only, but making such a sequence with 2 nucleotides is rather …
LanceLafontaine's user avatar
6 votes
1 answer
375 views

Are quaternary protein monomers unique to a particular protein complex?

I know that quaternary protein structures are formed exclusively via non-covalent bonds. My biochemistry professor discussed a viral capsid that is essentially one quaternary structure with 240 indivi …
LanceLafontaine's user avatar
3 votes
2 answers
815 views

Two subunits connected by only one disulfide bridge: quaternary structure?

I've always simply assumed quaternary structure to be characterized by non-covalent interactions such as hydrogen bonding, van der Waals interactions and whatnot. However, if two distinct polypeptides …
LanceLafontaine's user avatar
1 vote
0 answers
58 views

Visualizing secondary RNA structure binding to target

I am designing synthetic ribozymes, and need to see the secondary structure that arises from its flanking arms binding to a target mRNA. I've used Mfold as well as IDT's OligoAnalyzer (Hairpin), but t …
LanceLafontaine's user avatar
2 votes
3 answers
167 views

What biochemical molecule viewer allows for changes in amino acids and resulting tertiary st...

I am familiar with the Jmol, Rasmol and PyMoL softwares, and was recently introduced to BioBlender. However, I am completely unaware if any of these programs (or others) are capable of loading a .pdb …
LanceLafontaine's user avatar