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Results tagged with structural-biology
Search options questions only
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user 3553
The study of the molecular structure of biological macromolecules and how that structure relates to their function.
5
votes
1
answer
87
views
How many residues can a reliable ab initio structural model contain?
A recent question on ab initio that I answered involved touching on the limitations of ab initio modelling. A review from 2009 put forward that typically only in the order of 100-110 residues could be …
- 11.3k
1
vote
1
answer
131
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What is internal symmetry in membrane proteins?
I have come across the term "internal symmetry" in the context of membrane proteins, but have never found a satisfactory definition.
I'm struggling to figure out exactly what this term means... What …
- 11.3k
14
votes
4
answers
3k
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What are the benefits of elucidating the three-dimensional structure of a protein?
I have spent months as a student working on trying to form a tricky protein crystal. But I have never actually had explained to me why the structure will be useful. Once elucidated, what can we potent …
- 11.3k
12
votes
1
answer
4k
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What is the transmembrane 'Positive-Inside Rule' nowadays? Has the definition changed over t...
First definition.
Two publications by von Heijne in 1989 and 1992 coined the 'Positive-Inside rule' and showed it's practical value in topology prediction of transmembrane helices. It was clearly defi …
- 11.3k
16
votes
1
answer
64k
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How can Valonia ventricosa cells get so big?
Valonia ventricosa are single-celled algae that range between one and few centimetres. In rare cases, they can reach sizes exceeding 5cm. They range from grass-green to dark green, and some are even a …
- 11.3k