Skip to main content
10 votes

What are the odds of being an albino human and have Down syndrome?

It is correct if (and only if) albinism and Down syndrome are independent events, that is, if albino people is not more nor less likely to have Down syndrome than non albino people (and vice-versa). ...
Pere's user avatar
  • 586
10 votes
Accepted

Saturated Mutagenesis Screening

This sort of method is indeed quite useful and frequently used in synthetic biology: I've used a similar approach before to generate 5' insulators for promoters. Calculating the exact theoretical ...
jakebeal's user avatar
  • 6,987
8 votes

Statistics: How are protein species distributed over cell types?

From my searches, there is no single resource that includes an atlas of all human proteins produced across all human cell types. However, there are several recent mass spectrometry studies that look ...
acvill's user avatar
  • 8,296
8 votes
Accepted

Long-term efficacy and absence of side effects of anti-covid vaccines

You are correct that we have been creating and approving vaccines for a very long time, so the procedures for looking at efficacy and side effects of vaccines in general long-term are quite well ...
MattDMo's user avatar
  • 15.3k
7 votes
Accepted

Which statistical test should be used for GC-content comparison?

You could try a permutation test. These are a kind of non-parametric statistical test which involve creating your own null distribution from your data. Your hypothesis $H_{1}$ in this case, is that ...
user438383's user avatar
  • 2,351
6 votes

What is the name of this graph/plot?

I think it is Chord Diagram. you can see this for more information. "A chord diagram is a graphical method of displaying the inter-relationships between data in a matrix. The data are arranged ...
SRhm's user avatar
  • 192
6 votes
Accepted

How many (taxonomic) families are there?

The 2011 paper How Many Species Are There on Earth and in the Ocean? indirectly answers this question as well as any other source you'll find I imagine. It estimates how many species there are total ...
Oosaka's user avatar
  • 3,245
6 votes
Accepted

What is the best method to check for differential gene expression in large dataset? I want to identify aging differentially expressed genes

A standard pipeline for DGE would be Salmon for (pseudo)mapping + DESeq2 for statistical analysis. Salmon is one of a set of modern, fast and accurate mapping software. Requires a transcriptome to be ...
Greg's user avatar
  • 224
5 votes
Accepted

Does one need to perform two Chi-square tests?

You should just have 1 chi-square test to test the hypothesis. Note that the problem is asking about F2 generation, not F1. H0 in a chi-square test is your prediction based on a model; H1 is that ...
Bryan Krause's user avatar
  • 45.7k
5 votes
Accepted

What are the odds of being an albino human and have Down syndrome?

Probability of independent events Assuming the albinism and Down syndrome are independent traits, then the probability of having both traits is the product of the probability of having each trait. ...
Remi.b's user avatar
  • 68.1k
5 votes
Accepted

Book about ordination in ecology

I took a class in ordination methods a few months ago and found the following books helpful in better understanding the various techniques: Multivariate Statistical Methods: A Primer by Brian Manley ...
Jenny Hansen's user avatar
4 votes
Accepted

Why does drinking milk lead to increased fractures?

The authors suggest a reason in their abstract: Given the observational study designs with the inherent possibility of residual confounding and reverse causation phenomena, a cautious ...
kmm's user avatar
  • 12.3k
4 votes
Accepted

Are sizes of potatoes normally distributed?

According to Evaluation of the Effect of Density on Potato Yield and Tuber Size Distribution potato tuber size was estimated using a normal distribution but they are not normally distributed They ...
Hachiloni's user avatar
  • 973
4 votes

Long-term efficacy and absence of side effects of anti-covid vaccines

I will try here to sketch an answer starting from where @MattDMo left off. Question: How do we evaluate possible long-term side effects of a vaccine? (With specific application to the recently ...
Roger V.'s user avatar
  • 3,852
4 votes

Beta-diversity for data with zeros

I would recommend using a Bray-Curtis dissimilarity matrix since it accounts for abundances and can handle the so called double zero problem. I'm on my commute now and so must return to this for a ...
theforestecologist's user avatar
4 votes
Accepted

How much does dry moose scat weigh and vary in dry weight?

MacCracken and Van Ballenberge, 1987 report that pellet size varies a bit by sex and age; male pellet dry weight (all measurements are dry) averaged 1.9 grams (range 0.9-2.9), female 1.3 g (range 0.6-...
Bryan Krause's user avatar
  • 45.7k
3 votes

Book about ordination in ecology

You might also want to consider: Tree diversity analysis by Kindt and Coe 2005. Freely and legally available here. Not very deep but nice and crisp introductions + its free. Numerical Ecology with R ...
JonJup's user avatar
  • 31
3 votes

How to assess if biological measurements follow a normal or a log-normal distribution

Preprocessing will and should always depend upon the biology that you try to answer or discover (e.g.: There might be an experimental rationale to believe that some genes behave differently in ...
tsttst's user avatar
  • 1,597
3 votes
Accepted

How to assess if biological measurements follow a normal or a log-normal distribution

From personal experience, nearly all count data whether from microarray or reads from RNAseq of some kind, requires a log transformation of the counts. Usually a small fraction is added to all values ...
akaDrHouse's user avatar
  • 1,309
3 votes
Accepted

Do experiences shape actions of insects? Animals?

"Simple" insects like fruit flies can learn to associate odors with food, e.g. see here for a pretty classic example. Drosophila even show some kind of depression which is acquired. Their sexual ...
Ashafix's user avatar
  • 695
3 votes
Accepted

How can the recurrence risk ratio be calculated?

If we look at web resources, what we will notice is that this ratio is not deployed at the family level but at the population level. In other words, when we look at a population, we can ask: What ...
Maximilian Press's user avatar
3 votes
Accepted

How many cells are there in C. elegans in each hour of its life?

The lineages provided at WormAtlas include references to the original publications. Concerning the embryonic lineage at the top of the page, the corresponding paper was published in 1983.1 Looking at ...
acvill's user avatar
  • 8,296
3 votes
Accepted

Is there a published calibration between footprint measurements to body length in moose?

Yes - I found a paper published in 1978 by Franzen et al "Alaskan moose measurements and weights and measurement-weight relationships" 1 In this paper they looked at a number of parameters ...
bob1's user avatar
  • 12.1k
2 votes
Accepted

What is the most appropriate way to normalize gene expression data?

Normalization of expression data is a big topic with new methods being published regularly. When approaching something like this you generally want look at people who have done similar things to what ...
Dermot Harnett's user avatar
2 votes

Different Effects of Detection Probability Between Presence and Count Data at the Same Location

Disclaimed: Not really an answer, but too long for a comment If I understand you correctly, this must depend entirely on the accumulated probablity of detection over the entire detection period (the ...
fileunderwater's user avatar
2 votes

How do you compare unpaired biological replicates?

Calculating fold change is pretty straightforward but you cannot do one on one comparison because they (control and treated) are not really paired (same sample). That's why IPA gives you six results (...
WYSIWYG's user avatar
  • 35.6k
2 votes
Accepted

What is the name of this graph/plot?

This is a Circos plot, often used for visualizing genomic data, but works equally well for migration and some other applications.
Kim's user avatar
  • 56
2 votes

Using proportion or a diversity index when dealing with just two strains

Extended upon the suggested statistic The proportion $p$ is definitely not a good measure of diversity. A proportion of 0 or 1 both indicates no species diversity as only one species exist. If one ...
Remi.b's user avatar
  • 68.1k
2 votes

Is there a gold standard for syphilis?

Specificity and sensitivity are terms used in the pharmaceutical and in vitro diagnostics (IVD) industries that have specific meanings relating to how the particular assay in question was validated. ...
MattDMo's user avatar
  • 15.3k
2 votes
Accepted

Mathematical/statistical models for forecasting population distributions of age, sex, weight, and height

The term you are looking for is demography - there are literally thousands of papers published on this topic. Each of your topics mentioned has its own models and prevailing theories, so without an ...
bob1's user avatar
  • 12.1k

Only top scored, non community-wiki answers of a minimum length are eligible