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At what calcium concentration does the Sodium-Calcium Exchanger (NCX) "turn on"?

I could not find the $K_d$ of NCX proteins in KEGG BRITE, BRENDA, SuperTarget, DrugBank, Uniprot, or PDSP Ki databases... (Also, I cannot understand the use of the word 'relevant' in the question you ...
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3 votes

Turning off the IP3 cascade

IP3 is indeed degraded, this is done by a specific phosphatase which is called "Phosphoinositide 5-phosphatase (INPP5A)". It catalyzes the reaction in the following way: 1-phosphatidyl-1D-...
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Why does hypocalcaemia cause increased muscle contraction?

Consider the pathophysiology of tetany, which is the involuntary contraction of muscles caused by hypocalcemia. From the tetany wikipedia page: Low ionized calcium levels in the extracellular ...
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How does coffee cause calcium loss in our body?

Caffeine and coffee do not seem to have any significant adverse effect on calcium metabolism. The supposed mechanisms are inhibition of calcium absorption in the intestine and stimulation of calcium ...
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2 votes

How is Vitamin D deficiency linked to multiple sclerosis?

I don't believe this is known mechanistically to any great degree. Mayo Clinic has an easily understandable post about this. In summary, the evidence for a relationship is that vitamin D levels ...
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2 votes
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How much does calcium reduce iron absorption?

In short: Calcium can inhibit absorption of iron, but this does not necessary have any significant effect on the long-term iron status in the human body. Iron (Linus Pauling Institute): The ...
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Calcium concentration in activated dendritic spines?

An earlier source for an estimate of ${[Ca]_{i}}^{+2}$ in spines comes from hippocampal slices of P13-P19 rats (Majewska et al. 2000). The resting ${[Ca]_{i}}^{+2}$ in this paper was ~80 nM and a back-...
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2 votes
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How to induce a steady increase in cyctoplasmic [Ca2+] in HEK293T cells? And is there any simple marker/method to confirm it?

As far as I know, microscopy (be it with dyes like fluor or with genome-encoded calcium indicators) is really your only good bet, especially for getting quantitative sensitivity, which I think is what ...
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Has anyone modelled calcium oscillations using Matlab software?

I wish to share an open-source modelling study on Ca2+ oscillations in astrocytes which contains a detailed description of the underlying math and even better, it has supplementary Matlab code ...
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1 vote
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Where do the Ca ions that causes neurotransmitter release from synaptic bouton, come from?

Short answer Neurotransmitter release is triggered by an influx of calcium ions from the extracellular space into the cytosol through voltage-gated calcium channels in the plasma membrane. Long ...
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Effect of extremely hard water on marine life?

Hard water helps in direct and indirect ways. Indirectly, hard water plays an important role in regulation of pH. Respiration and other physiological activities release substances into water that ...
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