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4 votes
Accepted

DNA-DNA cross-linking with formaldehyde?

The fact that there is no inter-strand cross-linking between different double strands might be just because the cross-linker cannot bridge the distance between amines of different bases on different ...
aretaon's user avatar
  • 131
2 votes

Why are GC-rich regions less condensed than GC-poor regions?

@ThoH.Ho and @Thawn. When banding chromosomes they are first treated with trypsin before staining with Giemsa dye. My understanding, and I have worked in the field of cytogenetics for quite a while, ...
NugFow's user avatar
  • 21
2 votes
Accepted

Meaning of the word "targeted" in a description of chromatin immunoprecipitation

Looking at the article, I think they could leave out the word "targeted". I think they used it because what is being enriched is not a promoter DNA, but the section of promoter DNA bound to ...
Polypipe Wrangler's user avatar
2 votes
Accepted

Can Euchromatin convert into Heterochromatin?

I would suggest in the future doing a small amount of research before asking. For example, the wikipedia page for euchromatin says this: Euchromatin participates in the active transcription of DNA to ...
Maximilian Press's user avatar
1 vote

Why are odd numbers of chromosomes (triploidy, pentaploidy) less common than even ones (tetraploidy, hexaploidy)?

Sexual reproduction means taking chromosomes from two parents. Most commonly, that means that each parent gives just half their chromosomes to their gametes, such that the offspring will have a full ...
Bryan Krause's user avatar
  • 45.9k
1 vote
Accepted

What’s so remarkable about position effect variegation?

Re: In particular, if the underlying DNA structure is changing, then wouldn’t we expect the progeny to inherit these epigenetic changes? Why is it so remarkable? Given the context of the quote, the &...
Armand's user avatar
  • 1,711
1 vote

Can untargeted metabolomics detect epigenomic changes such as methylation?

This is a fascinating question, and I spent a fair amount of time looking into it. From what I've been able to find regarding the relationship between metabolics and epigenetics, it seems that ...
Astrolamb's user avatar
  • 511
1 vote
Accepted

How do you read the histone code?

The "histone code" is not like the genetic code where one codon in an ORF always is translated to a single amino acid. It's closer to something like GC content or CpG islands: a single instance doesn'...
Charles E. Grant's user avatar
1 vote

Why are GC-rich regions less condensed than GC-poor regions?

Chromosome condensation seems to be primarily driven by epigenetic factors like methylation and histone modifications, not GC content. However, high GC content is associated with gene rich regions and ...
Charles E. Grant's user avatar
1 vote

Why does cell waste energy in meiosis, between meiosis 1&2

There is a phase between meiosis 1 and meiosis 2 called Interkinesis. During this phase centrosomes or centriole pairs undergo replication in animal cells, which is important for bringing true ...
Madhubala's user avatar
  • 123
1 vote

Dnase data for GRCh38

I am unsure that how much does it answer your question, but have a look at the homepage of DeltaSVM - In his work, Lee et al. have used similar datasets (only for GRCH37 I reckon) and I am sure they ...
Failed Scientist's user avatar

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