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Biology is a large field of knowledge! As you give examples drawn from population biology (logistic population growth and Lotka-Voltera models), I will assume you are mainly interested in ecology and evolution. For analytical models used in ecology and evolution, I highly recommend the book A Biologist's Guide to Mathematical Modeling in Ecology and ...


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MD is used for studying structural changes. Simulation of biochemical pathways involves the kinetics (you are not really looking at how enzyme structure changes when it binds to substrate). You can certainly pool all the modelling strategies together to make a hybrid multiscale model. There are many people who work on such kind of modelling approaches. You ...


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I suspect that what you are asking for is years in the future yet. Bear in mind that the use of CRISPR-CAS9 is just entering clinical trials for a very few, well studied diseases. Almost all the work with CRISPR-CAS9 is still limited to model organisms and tissue cultures. Are you referring to Adiposis Dolorosa? Apparently the cause is not actually known ...


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I've mostly skimmed the formalism you introduced, but getting to the 2nd half of your post, the answer is yes, you understood correctly the distinction between natural selection (aka adaptive evolution) and drift (aka neutral evolution), as well as the fact that it's not a given that natural selection would be the predominant effect in arbitrary ...


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Year on year reliable ab initio predictions are becoming more common for longer proteins. 400 residues is not an unfeasible length. Of course, loops still remain more of a challenge than helical and sheet secondary structures. At CASP13, the Google DeepMind team used AlphaFold to produce a good quality model (T0594) of a 774 residue protein which is a WD40-...


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