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10

These Chimpanzee adenoviral vectors do not bypass the innate immune system at all. In fact they are used precisely because of their activation of the innate immune system, which then results in greater immunity because activation of the innate immune system results in antigen presentation and then activation of the adaptive immune system. The reason they ...


6

The innate immune system has many different components to it. If we consider a natural virus, like the base adenovirus used as a vector used in the Oxford/AstraZeneca vaccine, then we can assume that the virus already has sufficiently effective strategies in place to deal with them. In particular: Physical and chemical barriers are irrelevant, given an ...


2

I believe the news report you cited is not accurate in its reporting. Of course, it's not actual science, and we will wait for the release of the actual science, but here's my understanding (which may end up being wrong): if vaccinated people get infected anyway, they have as much virus in their bodies as unvaccinated people. This seems to be incorrect. ...


7

This is a lateral flow assay. [image source] A sample is applied at one end of the strip and flows across to the other side by capillary action. It first encounters antibodies against the target antigen and which are conjugated to some reporter (in the image above, the reporter is colloidal gold). When the sample contacts these antibodies, they too will ...


1

There's no way to know what effect passage through one vaccinated individual would have on an unvaccinated individual. The relationship between a virus's fitness in a particular host and the severity of disease it causes in that host is not straightforward, but generally we would expect a virus variant that can infect a vaccinated host well enough to pass on ...


3

The source for the linked article is this FDA factsheet, which gives the following description for the Pfizer-BioNTech COVID-19 Vaccine (emphasis mine): The Pfizer-BioNTech COVID-19 Vaccine is supplied as a frozen suspension in multiple dose vials; each vial must be diluted with 1.8 mL of sterile 0.9% Sodium Chloride Injection, USP prior to use to form the ...


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