4 votes
Accepted

How does the dopamine spike from drugs compare quantitatively to pleasurable non-drug activities?

This review article [1] gives dopamine responses for rats (similar to the BBC article above) and includes references to the underlying studies: Sex/Food: 150% - 300% Alcohol/Ethanol: 190% (1g/kg) *...
Andy's user avatar
  • 61
3 votes

Why does excess dopamine activity in the pleasure centers results in less pleasure in schizophrenics?

Short answer The dopamine hypothesis includes brain regions with reduced dopamine transmission as well. The prefrontal cortex in specific has reduced dopaminergic activity and is implicated in ...
AliceD's user avatar
  • 52.4k
3 votes
Accepted

Does cocaine bind competitively or non competitively to DAT?

Cocaine binds competitively to DAT, though not in precisely the same binding site, rather there is overlap, and many of the same amino acids are involved in binding of each. Amphetamine and ...
Bryan Krause's user avatar
  • 45.7k
2 votes

Number of dopaminergic neurons in VTA

Approximately, 250000-440000 neurons in Humans (Rice et al., 2016). The substantia nigra/ventral tegmental area (SN/VTA) complex is a heterogeneous collection of dopaminergic cell groups that ...
WYSIWYG's user avatar
  • 35.6k
2 votes
Accepted

What is this type of diagram called and how to interpret?

They used a stain that marks tyrosine hydroyxylase (most likely using an antibody to TH, followed by a secondary antibody tagged to an enzyme that then produces a dark precipitate in the presence of ...
Bryan Krause's user avatar
  • 45.7k
1 vote

How fast is dopamine released in the brain?

Dopamine is a neurotransmitter and released from synaptic ends via transporters. Such a release happens within milliseconds; the time present Dopamin needs to move some tens of nanometers. Adrenalin ...
KaPy3141's user avatar
  • 1,597
1 vote
Accepted

Number of dopaminergic neurons in VTA

Integrating the information from @WYSIWYG's excellent answer, it appears the dopaminergic neuron count lies at: 4k for mice - Triarhou, 1988 10k for rats - German and Manaye, 1993 250k-440k for ...
TheChymera's user avatar
  • 1,336
1 vote

Dopamine and other neurotransmitter release during music listening

Here is an article I found on google scholar. It links an increase in 5-HT a serotonin neurotransmitter when listening to pleasant music. https://link.springer.com/article/10.1007/s004060070031
Laura's user avatar
  • 11

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