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“The question is if there’s some reason this is the definition of ketogenic amino acids” The answer from @user1136 covers the biochemistry of the degradation of ketogenic and glucogenic amino acids. However it doesn’t answer this part of the question directly, which is what I shall use my answer to add. Just as we may classify amino acids as hydrophobic or ...


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The fundamental 'problem' with acetyl-CoA is that it cannot be converted to glucose via the tricarboxylic acid (TCA) cycle: a two-carbon compound (acetyl-CoA) enters the TCA cycle, but two carbons are lost as CO$_2$ during each round of the cycle (in the two decarboxylation steps, ie in the reactions catalyzed by isocitrate dehydrogenase and by the alpha-...


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