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1

In general, yes, administration of enzymes in some form or another can be used to treat a deficiency. A common example of this is the use of lactase to treat lactose intolerance. Since lactose intolerance results from the body not producing enough (or any) lactase, you can take oral lactase to alleviate the symptoms: Lactase products are tablets or drops ...


2

There would seem to be two possibilities: The enzyme has differential specificity for different substrate NDPs. or The deciding factor is the relative concentrations of the different NDPs in the cell. Although the structure of the enzyme has been determined there do not appear to be any studies that would distinguish between these possibilities. This is ...


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The process of self-degradation of a protease is called autolysis, and the rate of autolysis depends on many factors including temperature, pH, and enzyme concentration.1,2 While most proteases show reduced proteolytic activity with increased autolysis, some proteases demonstrate increased activity after they are self-hydrolyzed. The most notable example is ...


4

I would define a “polybasic cleavage site” as: A region on a protein consisting of several basic amino acids (generally arginine (R) and lysine (K), rather than histidine) that determines the substrate specificity of certain classes of proteases for that protein. It can also be regarded as a recognition site for the enzyme. The relevance of this to the ...


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A polybasic cleavage site is a cleavage site consisting of polybasic amino acids. An acid is polybasic when it is able to donate more than one proton in aqueous solution. In a titration curve, polybasic acids show as many equivalence points as they are poly. https://www.w3spoint.com/ionization-of-a-polybasic-acid


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Coenzymes and cofactors are almost the same. In general, coenzymes are a subgroup of co-factors. Actually, co-factors are two types Metallo cofactors and organic cofactors. You can read the difference between cofactors and coenzymes using the given link for better understanding. https://www.biologybrain.com/examples-of-cofactors-and-coenzymes/


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