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Yes, Sodium phenylbutyrate can upregulate the transcription of silenced genes by inhibiting the activity of Histone deacetylases (HDACs). Histone acetylation performed by Histone acetyltransferases (HATs) helps in activation of genes, while deacetylation performed by HDACs is responsible for gene silencing. This makes HDACs a potent drug target to treat ...


Sort of. Histone deacetylases act on a particular region on the chromatin fiber to decrease or even silence the expression of the genes in such region. According to the study, PB has the capacity to inhibit the activity of histone deacetylases, which implies that the effect of PB, is to the make the cell less able to decrease the expression of certain genes, ...


60 residues is the smallest I could find, ref below.

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