4

A methylated nucleotide is the same nucleotide, for the purposes of base-pairing events. The methylated base will be paired with its Watson-Crick opposite after replication, for instance (and methylation will even persist after replication).


4

First, let me qualify the idea of "problematic" epigenetic modifications by saying that the impact of a modification on an organism is often dependent on the environment. That is to say that outcome is dependent on the interaction of genetics (or epigenetics) and the environment in which the associated genes are expressed; e.g. a mutation or modification ...


3

Generally speaking, epigenetic modifications are not inherited as they are reset during embryogenesis. However, subsequent epigenetic modifications can be acquired during the period of pregnancy, which as a mechanism depends on the epigenetic state before the reset and on the physiological conditions of the mother including nutrition, health, stress, etc.. ...


2

I don't think there is an obvious contradiction here. (1) Mapping neuronal function to the perception of threat (or emotions in general) is often advertised as well-understood, but in fact it is not. Serotonin-concentration-based models (such as the monoaminergic theory of depression) are unavoidably imprecise because ”the brain is not soup”. Additionally, ...


1

Epigenetic changes can only be passed directly onto the next generation when they occur in the cells that proliferate into the gametic cells (ovum and sperm cells). There is some research with rat models that show the inheritance of epigenetic changes over several generations, so it´s possible. (an example for cocaine-addiction: https://www.nature.com/...


1

The Methylation will change the individual nucleotide(s) and persist after replication. However the order of the base pairs does not change, so the information in the DNA will still remain , and the base pairs remain with their same partners.For an analogy consider a hardcover book as the DNA . Then the author of the book signs the cover. The signature is ...


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