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What are the potential dangers (if any) facing the twin girls recently born in China with their CCR5 gene modified?

Important notes: I am not going into the ethical aspects of editing/removing CCR5 in human embryos, neither will I discuss potential effects of introducing that mutation into the human population....
Nicolai's user avatar
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6 votes
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Can the spike protein created by the Covid mRNA vaccines be created independently of the human body, and is there a higher cost to that?

What you describe, creating the spike protein independently and delivering it, is exactly what is done by subunit vaccines, such as the COVID-19 vaccine developed by Novavax. As already noted in @...
jakebeal's user avatar
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3 votes

Do bacteria duplicate the copied virus DNA to put into a Cas9 protein when fighting the virus off again?

So does the bacteria then copy that portion of bacteria that it had copied in the past to put into the Cas9 protein? The DNA is not copied, but rather transcribed. The captured piece of viral DNA (...
acvill's user avatar
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3 votes

What are the potential dangers (if any) facing the twin girls recently born in China with their CCR5 gene modified?

2019-09-29 update: the answer below is based on a scientific paper that seems to have a major flaw, see https://www.statnews.com/2019/09/27/major-error-undermines-study-suggesting-change-introduced-in-...
Franck Dernoncourt's user avatar
2 votes
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Convert fasta to ascii?

FASTA files are just text files, so you can open them up in your favorite text editor to see what they look like. The file you linked has a single entry. The first line begins with ...
MattDMo's user avatar
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2 votes

What advantages could there be for using the unseen variant chosen by He Jiankui instead of the naturally occurring CCR5-∆ 32 mutation?

Possibly He Jiankui was using Cas9 without a template DNA. If so, this generates double-stranded breaks that are repaired through processes such as non-homologous end joining (NHEJ) that often ...
tyersome's user avatar
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2 votes

Why doesn't HIV give you cancer if retroviral gene therapy gives you cancer?

Short answer: Most HIV-infected cells will die before transforming into cancer. Retroviral gene therapy may increase risk of cancer since the integration into the cell's genome can be faulty (strand ...
markur's user avatar
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2 votes

Current state of Gene Therapy

The scope of this question is too wide to be answered on Biology SE. However I will give you very brief answers to your questions (as I have rephrased them) and point you towards some sources of basic ...
David's user avatar
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1 vote

Risks in bacterial phage therapy

You run the risk of the killed cells suddenly releasing huge quantities of cytokines. If this occurs you may cause spike in capillary permeability and basically create massive sepsis. The bacteria ...
Richard Stanzak's user avatar
1 vote

How would you effect bulk DNA gene therapy for a human?

A major drawback and problem with your idea is that some genetic problems are developmental and have no effect if applied on adults. For example, a gene known to cause crooked teeth would have to be ...
user1258361's user avatar
1 vote
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which of these fields will cure aging?

I think the structure of this question could be less opinion based as De Novo stated above. But a recent article published by mayo clinic will help shed light on the question. Falls under the category ...
Elijah's user avatar
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1 vote
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Using viruses to treat altered or misconfigured DNA

Consider how a Retrovirus can modify existing cell DNA to 'execute instructions' on its behalf. Not only retroviruses do that. Actually, pretty much all viruses use the machinery of the host cell on ...
Remi.b's user avatar
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1 vote

Possible complications due to gene-therapy?

Your question is too broad. It is better to take some specific example. Not all cell's in the body divide. If you take cell out of the body and want to return it back, it must divide. So we probably ...
Robertos's user avatar
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