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Jackson Labs offers a service for this for what looks like a reasonable price. I have no experience with the service other than general good feelings about Jackson. We have a unique selection of mouse single nucleotide polymorphism (SNPs) panels useful for a diverse set of mouse research applications. Applications of SNP scanning services ...


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Case A: Not Breeding True If you cross-breed two random dogs, the offspring are likely to only vaguely resemble either parent. If you could clone a random dog to obtain two genetically identical dogs with different sex, you would likely still only get offspring that vaguely resemble their parents, because the chromosomes of the parents would come in pairs ...


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In the context of Darwin's Variation under Domestication, "true breeding" is a phenotypic characteristic rather than a genetic one. True-breeding organisms produce offspring that are identical to themselves, concerning some trait -- i.e. white fantails, when bred with white fantails, produce characteristically white offspring. For diploid organisms, true-...


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I can't find a reference to a "TARIS model" in the paper you linked, but we can break down the molecular circuitry of this lineage tag tracking system step-by-step. The authors use a type of Tet expression system in order to tightly control the expression of a hyperactive Sleeping Beauty (HSB) transposase. In the absence of doxycycline, the reverse ...


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Spotted hyenas are a matriarchal society and female hyenas are larger than males. Also, female hyenas dominate males.


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One very important signal for angiogenesis are the Vascular endothelial growth factors (VEGF) (a small group of ~5 similar proteins). They generally promote generation of new blood vessels & migration of these towards the source of VEGF expression. Blocking VEGF signalling (mostly be blocking the receptors with antibodies) has been a pretty good ...


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Galectins are family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. These proteins are produced by tumor cells and promote angiogenesis. These secreted Galectins are used by endothelial cells to enhance migration and proliferation. And play various roles during development of tumor such as cellular ...


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"The sickle cell trait" affects people who are homozygous for the HbS allele. These individuals only have hemoglobin S (after all fetal and embryonic hemoglobin genes are switched off). Hemoglobin S forms large crystal aggregates under conditions of low oxygen tension, and cause red cells to sickling and then to lyse. Anemia is most often severe and lethal. ...


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