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Haplotype blocks may cover more than just one gene. While positions within a gene are also in high linkage disequilbrium (or well correlated) with each other, this phenomena of high LD may extend beyond the gene body and overlap with the next gene. A good visual representation of this comes from Jeffreys et al. in the figure below: Red means more LD, ...


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They are different. Genomics is the general science of sequencing whole genomes (or sometimes, the majority of the genome, or all the protein-coding genes, as in transcriptomes). Population genetics uses molecular data (usually DNA sequences, but not always) to make deductions about the characteristics of a population, or the relationships among biological ...


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This can occur if the Ab genotype is lethal, i.e. you won't observe individuals with a Ab genotype. Allele lethality is a common mechanisms that can explain non-mendelian inheritance of a trait. For the question of which LD metric to use, this is tricky. Under the assumption that allele lethality is indeed at play, you observed perfect haplotypes, so D'=1 ...


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Yes, these are different measures, and agreeably confusing. The "more than 99%" figure refers to pairwise distance. This figure (actually 99.9%) means that if you were to line up the 3 billion nucleotides of DNA from of any two people, on average, 1 in 1000 of these nucleotides would be different. Among siblings, this number would be even smaller. The 50% ...


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As I understand it from skimming the Cell paper and that by Bobay and Ochman, 2018, which it cites, the concern is the validity of the established method of defining viral species. Quoting from this latter paper: Members of a biological species are defined by their ability to exchange genetic material… The problem would appear to be that ssDNA and RNA ...


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I don't think this is an answer, but I have been told to write it as an answer by a mod: it means " ...the standard model of uncontrolled, widespread, pervasive mosaicism..." Mosaicism mechanisms are probably for another topic, Wiki states that: Genetic mosaicism can result from many different mechanisms including endoreplication, anaphase lag, and ...


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