New answers tagged

3

The breadth of examples of environmental exposure directly influencing changes in gene expression in humans is astonishing, occurring at every developmental stage from conception to death. As an example, consider the environmental exposure to a reasonably high dose of a gram negative bacteria with lipopolysaccharide. Immune cells recognize this very ...


2

I think your question is interesting, though the use of "expression" is misleading in context of your rabbit example. Examples of environmentally influenced gene-expression in humans? ... That is, a phenotype which requires BOTH a certain genetic background and particular environmental influences in order to be expressed? In the example you give, ...


1

The short answer is "yes". Here is an early example: https://science.sciencemag.org/content/265/5181/2049.abstract I am sure that with some searching around you can find the most recent version. I was able to find somewhat more recent maps here. The data has to be in the UCSC genome browser somewhere. Most likely you should find your 7000 cM estimate source ...


1

NRAS is indeed a molecular switch, as part of the MAP-Kinase signaltransduction pathway it acts in controling the signal which goes downstream and finally will cause the expression of genes. In the case of NRAS this includes genes for proliferation, which is important for tumors. In principle, this looks like shown on this figure (from here): RAS (this is ...


7

The question makes it clear that the poster is aware of the different ways of estimating human genetic variation, and he is also no doubt aware of the fact that Wikipedia is written by “people like you” who may not be experts in the field or have updated an old entry based on limited data. Let me address what appears to be the cause of confusion in this ...


Top 50 recent answers are included