Following technquies are used for developing fully human monoclonal antibodies:
Complementarity-determining region (CDR) engraftment: This method is
performed by preparing cDNA library. CDRs are amplified from a mouse
hybridoma cell line, and later these sequences are engineered into
the human variable light and heavy chains.
Using transgenic mice with ...
I found this small article that seems to cover all your questions:
Being considered a human monoclonal (many of the identical antibody, as opposed to different antibodies for the same target) antibody does not mean it is produced by a human body; it means that ...