We’re rewarding the question askers & reputations are being recalculated! Read more.

New answers tagged


Following technquies are used for developing fully human monoclonal antibodies: Complementarity-determining region (CDR) engraftment: This method is performed by preparing cDNA library. CDRs are amplified from a mouse hybridoma cell line, and later these sequences are engineered into the human variable light and heavy chains. Using transgenic mice with ...


I found this small article that seems to cover all your questions: https://www.sciencedirect.com/topics/medicine-and-dentistry/human-monoclonal-antibody Summary: Being considered a human monoclonal (many of the identical antibody, as opposed to different antibodies for the same target) antibody does not mean it is produced by a human body; it means that ...

Top 50 recent answers are included