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Following technquies are used for developing fully human monoclonal antibodies: Complementarity-determining region (CDR) engraftment: This method is performed by preparing cDNA library. CDRs are amplified from a mouse hybridoma cell line, and later these sequences are engineered into the human variable light and heavy chains. Using transgenic mice with ...


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I found this small article that seems to cover all your questions: https://www.sciencedirect.com/topics/medicine-and-dentistry/human-monoclonal-antibody Summary: Being considered a human monoclonal (many of the identical antibody, as opposed to different antibodies for the same target) antibody does not mean it is produced by a human body; it means that ...


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