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This is a very interesting question. One of the most important considerations in patients on long-term immunosuppression is the risk of complications, whether infections or (more dangerously) cancer development; because of this if we can taper the dose then we would like to. This paper specifically discusses a lot of those risks. You mention prednisolone ...


5

The development of cancer has various reasons. For example in more than 50% of tumors, p53 is mutated. p53 among other things regulates mitosis and forces the cell to arrest in a specific growth state if other systems detected a mutation in the DNA. But in your special case we have to look at major histocompatibility complexes (MHCs) and NLRC5. There are ...


4

Short answer While sertraline may theoretically affect the immune system, there is no evidence, as far as I know, that it negatively impacts immune status. Background In the article (Atkin-Smith et al., 2015) sertraline (a.k.a. Zoloft, an antidepressant) is shown to block the formation of ‘beads-on-a-string’ protrusions and apoptotic bodies after from dying ...


3

Your question is very complex, so for now I'll focus on a few points and answer these first: Why hasn't there been visible progress on a gene-blocking approach? There are all sorts of ways to block them - find all the proteins and other products that promote or cause inflammation, then consider all sorts of options to stop them. Options including blocking ...


2

Histamine is produced in allergic reactions. - True Histamine is produced against allergic reactions - False Okay. Lets get a few things right here first. An allergy is an inappropriate immune hypersensitive response. It is something, we are not supposed to have. A small harmless pollen grain, in normal people shouldn't initiate an allergic reaction. IgE ...


2

There are several types of cancer immune evasion. Such as releasing immunesupressive cytokines, downregulation of MCH and comprising mutiations which are not immunogenic. If the cancer at a tissue is evading immune system by immunosupressive cytokines it may not be affected from auto-immune attack. However if the cancer is not attacked by the immune system ...


1

Patients receiving immunosuppressive drugs do fall into the same category as patients with HIV-related acquired immunodeficiency - that is, they are all immunocompromised and face similar risks of infection, cancer, etc. The difference emerges over time: when the immunosuppression is controlled and monitored, a patient can retain some immune function, and a ...


1

Mostly wrong, yet not a bad notion. Most* (*all? Been too long.) forms of cancers turn off the natural identification scheme (self-MHC or major histocompatibility complex) as well as the limits on replication. This is because there is a self-kill switch attached to that system. A cancer would need to release the stand-down signal in a timely fashion, ...


1

During stress glucocorticoids, which are steroid hormones produced by adrenal glands (such as cortisol and corticosterone), are released into the blood-stream. These hormones have anti-inflammatory effects. You may say that they suppress the immune system. The circadian rhythm, which controls the sleep-wake cycle, also controls glucocorticoid secretion, ...


1

Yes, we should. But Ebola doesn't completely immunosuppress us, or there would be no survivors. Ebola kills by overwhelming the body before enough antibodies are formed to fight it. If you're one of the survivors (as about 40-50% are, more with good care), you'll have antibodies to Ebola in your blood which might help someone else infected with Ebola. If ...


1

One possibility is that these antibiotics could disrupt your normal gut bacteria. Given that your gut has the surface area of a tennis court and is typically coated with symbiotic microbes, antimicrobial therapies could dramatically change the population dynamics of your gut ecosystem. One might imagine that the immune system of the gut is in homeostasis ...


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