6
votes
Why doesn't glucagon promote glycogenolysis in muscle?
Glucagon needs glucagon receptors to have an effect on the tissue or organ in question, and your answer can be found there. Glucagon receptors are found in the liver, like you say, but they're also ...
4
votes
Accepted
Why do some tissues have insulin-dependent glucose transporters and others not?
Summary
The whole point of hormones is that they allow the organism to control the metabolism of tissues in an integrated manner, rather than each tissue acting independently. Insulin, glucagon and ...
- 26.3k
4
votes
Why doesn't the immune system ever destroy the glucagon-producing alpha cells in the pancreas? Why only insulin-making beta cells?
As a result of differences in antigen presentation and recognition, the immune system targets the insulin-producing beta cells selectively within the pancreas, while the alpha cells that produce ...
- 52.5k
2
votes
Accepted
Full name for stem cells
Human Embyronic Stem Cells (hESC) can be programmed to differentiate into a number of different types of tissue depending on the signals you give or withhold.
Source: BioTime
The company Viacyte is ...
- 8,119
1
vote
Is the Insulin Receptor Considered an Enzyme?
Yes, the insulin receptor can be viewed as an enzyme, since it catalyzes a reaction -- phosphorylation of tyrosine residues on its substrates. But since the protein has multiple functions, it's ...
- 5,735
1
vote
The insulin protein of apes & chimpanzees
On the Ensembl website you can find an easy way to compare genetic sequences of the available genome references, including the one of several primates.
Here a query example:
http://www.ensembl.org/...
- 3,128
1
vote
Why does activity cause hypoglycaemia in diabetics?
While doing physical activity you are using your skeletal muscles. When the skeletal muscles are active i.e. contracting and relaxing during exercise, especially moderate or severe exercise, they (...
- 11
1
vote
Accepted
Can monoclonal antibodies be used to transport insulin
Technically you can link two proteins together, but why would you want to do this?
Antibody drug-conjugates are used to specifically target cells which can be differentiated from the healthy cells by ...
- 52.5k
1
vote
Accepted
How do receptors lose their sensitivity?
The major celltypes responsible for getting rid of blood glucose are the liver, adipose tissue (fat cells) and the muscles.
The problem of how muscles becomes insulin resistance was solved by a team ...
- 590
1
vote
Would intravenous insulin + glucose significantly accelerate glycogen synthesis?
Concluding from this 1991 PubMed article, intravenous (or subcutaneous) insulin may not stimulate glycogen synthesis more than naturally secreted insulin.
Experiments carried out in man have ...
- 8,104
1
vote
Activation of Glycogen Synthesis by Insulin - mechanism and cellular location?
Insulin, like glucagon, binds to receptors on the surface of muscle cells and illicits a response that is transduced to produce changes of phosphorylation in the enzymes controlling glycogen turnover. ...
- 26.3k
1
vote
Accepted
Role of the Hypothalmus in the control of Blood Sugar
Your question doesn’t make it clear whether you think that the pancreas must be under the control of the hypothalmus, or whether you are asking whether it has an influence on the pancreas in relation ...
- 26.3k
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