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4 votes
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Can a symptomatic, recent recipient of live attenuated dengue vaccine Qdenga transfer the virus to mosquitoes if bitten?

The possibility of mosquitoes becoming infected with vaccine-strain DENV by taking a blood meal from a vaccinated human has been found to be low. Transmission of vaccine-strain DENV to unvaccinated ...
timeskull's user avatar
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4 votes
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Why has malaria only now started to develop resistance against artemisinin?

Selection pressure (1, 2). One way or the other, there were few enough people taking the drug that it didn't really "matter" to P. falciparum (the deadliest of the malaria-causing parasites) on a ...
tel's user avatar
  • 3,781
4 votes
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How Anopheles crop doesn't digest gametocytes of P. vivax?

Short Answer: Nothing prevents it, most Plasmodium (gametocytes/gametes/zygotes/ookinetes) are killed. Background: After lots of search, I finally found a definite answer about this. According to ...
another 'Homo sapien''s user avatar
4 votes

How Anopheles crop doesn't digest gametocytes of P. vivax?

Disclaimer: I am trying to answer the question without finding any academic research on the topic. So, appreciate hypotheses and feel free to point out mistakes. Short Answer : Co- Evolution Broad ...
Mockingbird's user avatar
3 votes

Why do Kupffer cells not attack malarial sporozoites?

Indeed the process is even more interesting than thought: sporozoites actively attack Kupffer cells and let themselves get eaten! In a 2001 research, Pradel et al found that sporozoites pass through a ...
another 'Homo sapien''s user avatar
3 votes

Why do heterozygous individuals have increased resistance to malaria?

Very interesting explanation has been proposed by Ferreira A. et al. 2011. Briefly, red blood cells of individuals carrying homozygous point mutation in haemoglobin beta-chain tend to be more prone to ...
hibernicah's user avatar
3 votes
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Mathematical model for malaria

I am afraid you may have to read your textbook more closely. The question on page 29 states that this equation models the proportion of infected humans. If $I$ $≥1$ that would mean that there are ...
GrumpyMammoth's user avatar
2 votes
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How do sporozoites travel into the human host when the mosquito is sucking blood?

Nice question! Basically, the mosquito does not only suck; it also injects some saliva into the host with its saliva glands. From National Geographic: The mosquito starts salivating as soon as it ...
rotaredom's user avatar
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2 votes
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How long ago did the mutation arise that gives rise to sickle-cell disease?

In a fairly recent review P W Hedrick surveys a number of gene variants associated with resistance to malaria. He explains that: The impact of malaria is thought to have increased between 10,000 ...
Alan Boyd's user avatar
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1 vote

How having sickle cell trait would provide resistance to malarial parasites?

I would say that there are at least 2 explanations: Higher levels of free heme in the blood of individuals with sickle cell anaemia/sickle cell anaemia trait. Free heme is toxic to Plasmodium.sp ...
hibernicah's user avatar
1 vote
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Why is Artemisinin Compound Therapy preferrable over Artemisinin therapy with regards to drug resistance?

The idea is rather simple. When an antibiotic is used, it becomes a driver to select for a mutant that has resistance towards the antibiotic. Let say the probability for that happening is P1 (Lets say ...
JayCkat's user avatar
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1 vote

Does malaria have a reservoir host?

There are 5 species of Malaria the can infect humans, and Chimpanzees and gorillas have also been found with 5 species, including vivax and falciparum. https://www.ncbi.nlm.nih.gov/pmc/articles/...
bandybabboon's user avatar
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1 vote

Geographical distribution of malaria and tuberculosis

The statement in the question about the current distribution of these diseases is not strictly accurate, as shown by the graphic below. [Malaria graphic: Wikipedia user, Percherie (2006); TB graphic: ...
David's user avatar
  • 25.9k

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