44 votes
Accepted

Are drugs made bitter artificially to prevent being mistaken for candy?

Short answer A bittering agent may be applied to therapeuticals to prevent pediatric poisonings, but many drugs inherently taste bitter by themselves. Background Bitter taste is thought to have ...
  • 51.6k
14 votes
Accepted

Inability of vultures to digest diclofenac

Via: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618889/ Post-mortem examination revealed extensive visceral gout in all diclofenac-treated birds (see electronic supplementary material). ...
9 votes
Accepted

Why is methanol poisonous?

Methanol is highly toxic in humans. As little as 10 ml of pure methanol can destroy the optic nerve and cause permanent blindness, while 30 ml dose is fatal (Vale et al, 2007). However, its toxic ...
5 votes
Accepted

Do drugs' levo isomers have a better interaction with the receptors in our body than dextro isomers?

This is purely coincidental. The term levo simply means the direction that the pure enantiomer of the compound rotates plane polarized light at a specific wavelength and has no direct bearing on the ...
3 votes
Accepted

How does cancerous tissue break down radioisotopes faster than normal tissues?

Cancerous tissues break down glucose faster, not radioisotopes. Doctors use PET technique to detect breakdown of glucose, and "hot spots" are investigated as potential tumors. Glucose can be labeled ...
3 votes
Accepted

Which kind of drugs get absorbed through epidermis?

According to a review (Prausnitz2004), marketed drugs with a dermal route of administration tend to fulfil the following criteria : Small molecular size (< 500 Da) High lipophilicity Small ...
  • 1,135
3 votes
Accepted

What chemicals/substances exist in green capsicum (peppers) that do not exist in red capsicum?

Your limited understanding is indeed correct - the different colours indicate different stages of maturation, even though different colour cultivars exist (e.g. some that remain green even if fully ...
  • 2,878
2 votes
Accepted

What is effectiveness of methyl-alcohol as sporicide?

Methanol (methyl alcohol) tends to lack sporicidal activity on its own. However, fresh mixtures of methanol and hypochlorite, with at least 15% methanol, are known to have low sporicidal activity. ...
  • 1,469
2 votes

How would a medication cause a one to maintain a different weight?

Based on my reading, weight gain, as in resetting your maintenance set-point, which is what it sounds like you are describing, is a very well-known side-effect of the serotonin selective reuptake ...
  • 3,432
2 votes

How does BH2 reduction to BH4 need only one NADPH molecule?

The short answer is that in reduction of BH2 to BH4 by dihydofolate reductase not only is a hydride ion (a proton plus an electron) transferred from NADPH to BH2, but the product also picks up a ...
  • 4,648
2 votes
Accepted

Are omeprazole and other members estrogenic and/or antiandrenergic?

There is not a lot of evidence that the compound itself is estrogenic, but it may affect how estrogen is metabolized in the body, leading to feminizing outcomes. Pubmed is a good source for ...
2 votes

Identifying substance in body fluid (serum, urine)

Dipstick urinalysis? source The urine dipstick has a bunch of squares, each with a chemical analysis ready to go. The dip will semiquantitatively show you what is in the urine. My bet would be ...
  • 2,946
2 votes
Accepted

How to reduce PPi concentration in blood samples by PPase

Bernhard et al. 1 describe a method for the treatment of human plasma with yeast inorganic pyrophosphatase. The PPase-treated plasma is used as both a diluent and a negative control in their PPi ...
  • 7,929
1 vote
Accepted

Is it advised to calculate QED parameters for salts?

I found the answer when I was reading about InChi in more detail. For example, to a bioscientist “glutamic acid” and “glutamate” are the same thing, but to a computational chemist the loss of a ...
  • 299
1 vote
Accepted

Does Cholestyramine (CSM) raise Tyramine levels?

I'm not sure why "tyramine" is in the name "cholestyramine", but the molecular structure of tyramine is not present as part of the molecular structure of cholestyramine. Specifically, in tyramine the ...
1 vote
Accepted

Is there a short-term, very strong anesthetic, which can be blocked/delayed by other substances?

Xenon. It is like an ideal anaesthetic. See here. Xenon is an interesting anesthetic as it appears to lack negative inotropicy and vasodilatation, giving great advantages to both patients with ...
  • 35.1k
1 vote

Does DHA increase the effects of clarithromycin?

You've misread the paper. Clarithromycin is metabolized in part by CYP3A, but to an active metabolite. A significant proportion of clarithromycin and its active metabolites are excreted unchanged in ...
  • 8,721
1 vote

What tests can be performed to test the purity and quality of the raw peptide HCG (Human Chorionic Gonadotropin)

A monograph from a pharmacopeia gives a good starting point for active pharmaceutical ingredient characterization. AFAIK there is no monograph for hCG nor your actual peptide of interest, but there is ...
  • 1,135
1 vote

Chemical structure prediction

For the reference, there is also USPEX, which works for a wide variety of molecular and continuous structures (mostly inorganic, though). USPEX can be used to predict stable crystal structures at ...
  • 229

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