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9

This question cannot be answered as simply as you put it, but it's not too much to elaborate on. The order of the base pairs will be drastically different, but the same proteins and amino acids will be coded for in genes, just at different points along the DNA. For example, you may find the same sequence to code for a protein in a mouse as in a human, but ...


5

Mice are mammals, like humans, so their proteins tend to show more homology with human proteins than non-mammalian options. They are also actually more closely related to humans than cats or dogs due to the relatively recent (~80 million year) separation of lineages that led to modern rodents and primates. Mice breed fairly quickly year-round and have ...


4

Yeah, it's not good: Social isolation (SI) rearing in rodents causes a variety of behavioral changes, including hyperlocomotion, anxiety, impulsivity, aggression, and learning and memory deficits. These behavioral abnormalities in rodents may be related to the symptoms in patients with neuropsychiatric disorders, such as attention-deficit hyperactivity ...


3

Not an easy question, but I got some references about it. Mouse LS cells are Fibroblasts growing in suspension culture, the paper in reference 1 has this paragraph in its Materials and Methods section: This cell line seems to be in culture since the 1940s, as the reference to Sanford, Earle and Likely, 1948 suggests. Digging up this reference (number 2 ...


3

It's common for the human immune system to create antibodies against many proteins, even some human proteins. Hemophiliacs who receive regular doses of clotting factor proteins often develop neutralizing antibodies against the clotting factor proteins, even though they are a human protein1. Therefore it's not surprising that antibodies would be developed ...


2

Here is a list of programs that could work: E-mouse Lab: http://e-mouselab.com, seems like the best fit for your requirements. ZooEasy: http://standalone.zooeasy.com/en/pedigree-software/breeding-mice/breeders/index.html, Cheaper, good for breeding and pedigrees. LabGuru: http://www.labguru.com, seems very professional and great for mice specimens as well. ...


2

This doesn't fully answer the question, but for those mouse skull sutures that do fuse, fusion is complete by about 45 days of age, according to Studies in cranial suture biology: IV. Temporal sequence of posterior frontal cranial suture fusion in the mouse. That suggests that most cranial expansion is more or less complete by about 6 weeks of age. I think ...


2

As mentioned in the comment, all antibodies have constant regions and variable regions. The variable regions are the binding sites on the ends of the two arms, and the constant regions are the rest of the molecule. When humans are injected with murine antibodies, the immune system recognises and sets up an immune response to them, through generation of HAMA. ...


2

Approximately, 250000-440000 neurons in Humans (Rice et al., 2016). The substantia nigra/ventral tegmental area (SN/VTA) complex is a heterogeneous collection of dopaminergic cell groups that extends from diencephalic to mesencephalic territories in many vertebrates, including rodents, non-human primates, and humans (Puelles and Verney 1998; see ...


2

I have also hit this issue. I was interested in full length amino acid sequences for the classical class I mouse MHC alleles. I was able to find a number of them on uniprot but not all. Here is my list below. Interested if anyone knows additional sequences to extend this: H-2 D H-2 Db H-2 Dd H-2 Dp H-2 Dk H-2 Dq H-2 K H-2 Kb H-2 Kd H-2 Kk H-2 Kq H-2 L ...


2

Jackson Labs offers a service for this for what looks like a reasonable price. I have no experience with the service other than general good feelings about Jackson. We have a unique selection of mouse single nucleotide polymorphism (SNPs) panels useful for a diverse set of mouse research applications. Applications of SNP scanning services Development of ...


1

Integrating the information from @WYSIWYG's excellent answer, it appears the dopaminergic neuron count lies at: 4k for mice - Triarhou, 1988 10k for rats - German and Manaye, 1993 250k-440k for humans - Rice et al, 2016


1

Apparently there's a really nice paper with some very informative figures on Cranial Base and Craniofacial Development in Mice. They measure the distance between key landmarks of the cranium over a period of 112 days. The paper does not specifically look for landmarks that allow a good positioning of the brain relative to the ear canal, but from their data ...


1

Because we have selected particular inbred strains that seemed "normal", at least superficially, and mostly for strains that produced good litters and didn't often bite the researchers. However, inbred strains of mice and rats have many deleterious mutations. In some cases they probably survive only because they are held in cages with ample food and water, ...


1

Some information on inbred strains of laboratory mice: https://en.wikipedia.org/wiki/Inbred_strain http://what-when-how.com/molecular-biology/pure-line-molecular-biology/ A relevant quote on the consequences of inbreeding: Inbreeding in allogamic organisms bring the deleterious recessive alleles to homozygosity; the immediate consequence is an increase ...


1

If you are referring to reducing the titer in the immunized animal, you could give the animal a drug that has immunosuppressive properties. Velcade (PS-341) is a drug that effectively reduces plasma cell counts. There are many immunosuppressive drugs available. If you want to reduce the antibodies affinity, you are undertaking a much more delicate process. ...


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