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In percentage, how much is the human genome (DNA) similar to the mouse genome?

This question cannot be answered as simply as you put it, but it's not too much to elaborate on. The order of the base pairs will be drastically different, but the same proteins and amino acids will ...
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5 votes
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Why is Mus Musculus a good model organism?

Mice are mammals, like humans, so their proteins tend to show more homology with human proteins than non-mammalian options. They are also actually more closely related to humans than cats or dogs due ...
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4 votes
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Does isolation have any effect upon mouse behavior?

Yeah, it's not good: Social isolation (SI) rearing in rodents causes a variety of behavioral changes, including hyperlocomotion, anxiety, impulsivity, aggression, and learning and memory deficits. ...
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3 votes
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Can one mouse gene have multiple human orthologs?

Yes. If duplication of the human gene happened after the speciation event, we have multiple orthologues. This is shown in the following diagram from Ensembl as one-to-many orthologue (...
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3 votes
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What are mouse LS cells?

Not an easy question, but I got some references about it. Mouse LS cells are Fibroblasts growing in suspension culture, the paper in reference 1 has this paragraph in its Materials and Methods section:...
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3 votes

human anti-mouse antibody

It's common for the human immune system to create antibodies against many proteins, even some human proteins. Hemophiliacs who receive regular doses of clotting factor proteins often develop ...
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2 votes
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Mouse Colony Software

Here is a list of programs that could work: E-mouse Lab: http://e-mouselab.com, seems like the best fit for your requirements. ZooEasy: http://standalone.zooeasy.com/en/pedigree-software/breeding-...
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2 votes

At what age does the mouse skull stop growing?

This doesn't fully answer the question, but for those mouse skull sutures that do fuse, fusion is complete by about 45 days of age, according to Studies in cranial suture biology: IV. Temporal ...
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2 votes
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human anti-mouse antibody

As mentioned in the comment, all antibodies have constant regions and variable regions. The variable regions are the binding sites on the ends of the two arms, and the constant regions are the rest of ...
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2 votes

Number of dopaminergic neurons in VTA

Approximately, 250000-440000 neurons in Humans (Rice et al., 2016). The substantia nigra/ventral tegmental area (SN/VTA) complex is a heterogeneous collection of dopaminergic cell groups that ...
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2 votes

Mouse H2 allele sequences

I have also hit this issue. I was interested in full length amino acid sequences for the classical class I mouse MHC alleles. I was able to find a number of them on uniprot but not all. Here is my ...
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2 votes

PCR markers for C57B6

Jackson Labs offers a service for this for what looks like a reasonable price. I have no experience with the service other than general good feelings about Jackson. We have a unique selection of ...
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1 vote

What is the size of different mouse brain cells?

In situ, cortical neurons have soma commonly in the range of 10-20 um (see for example https://en.m.wikipedia.org/wiki/Pyramidal_cell); it doesn't much matter if you talk of mice or any other mammal. ...
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1 vote
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why dead mouse doesn't bleed when we cut their skin?

From personal experience, extracting organs/tissues of over 1000 mice I can give some hints: Mice blood coagulates quite fast after death. If you need to extract blood, you are under time-pressure and ...
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1 vote
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Number of dopaminergic neurons in VTA

Integrating the information from @WYSIWYG's excellent answer, it appears the dopaminergic neuron count lies at: 4k for mice - Triarhou, 1988 10k for rats - German and Manaye, 1993 250k-440k for ...
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1 vote
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At what age does the mouse skull stop growing?

Apparently there's a really nice paper with some very informative figures on Cranial Base and Craniofacial Development in Mice. They measure the distance between key landmarks of the cranium over a ...
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1 vote

Inbred mice has no severe phenotype outcome?

Because we have selected particular inbred strains that seemed "normal", at least superficially, and mostly for strains that produced good litters and didn't often bite the researchers. However, ...
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1 vote
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Inbred mice has no severe phenotype outcome?

Some information on inbred strains of laboratory mice: https://en.wikipedia.org/wiki/Inbred_strain http://what-when-how.com/molecular-biology/pure-line-molecular-biology/ A relevant quote on the ...
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1 vote

How to inhibit formation of specific antibodies (to antisera)?

If you are referring to reducing the titer in the immunized animal, you could give the animal a drug that has immunosuppressive properties. Velcade (PS-341) is a drug that effectively reduces plasma ...
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