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What you describe, creating the spike protein independently and delivering it, is exactly what is done by subunit vaccines, such as the COVID-19 vaccine developed by Novavax. As already noted in @Amanda's answer, mRNA is great at amplifying a delivery, so you need a lot less to be delivered. The manufacturing process for the vaccine itself is a lot more ...


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Does the mRNA of the covid19 spike protein contain any nuclear localization signals? I take it you are talking about the coronavirus SARS-CoV-2, and asking whether its RNA genome contains any nuclear localization signals that act post-translationally as signals to specifically import the spike proteins into the nucleus. I cannot find any reports where any ...


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