6 votes

Are non-coding RNAs introns?

A clarification on introns and exons. While it is true that introns are not a part of the mRNA as March Ho said, they are essentially transcribed. This may seem trivial but it is important to note. ...
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6 votes

Are non-coding RNAs introns?

While Ankur's answer is correct, it must be noted that not all non-coding RNAs are introns. An intron must be excised from an mRNA, which therefore means that any non-coding RNA that is not part of ...
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5 votes

Are there parts of DNA that do not have genes?

Most the genome is not coding for proteins. Here is a pie chart of what the human genome is made of As you can see, only 1.5% of the human genome codes for proteins. The term gene is often a bit ...
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5 votes
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Why is Mus Musculus a good model organism?

Mice are mammals, like humans, so their proteins tend to show more homology with human proteins than non-mammalian options. They are also actually more closely related to humans than cats or dogs due ...
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3 votes
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Are pseudogene counted as a subtype of long non-coding RNA genes?

A note on nomenclature in modern biology As it stands, this question seems to assume there is some legal commission, Académie française, or the like that is devoted to continually determining ...
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3 votes
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Why does a cell need siRNA?

So if siRNA appears to be just a subtype of miRNA, can we confirm that? Or are there any other differences that make these two molecules different kinds of small non-coding RNAs? siRNA and miRNA ...
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3 votes

What is meant by "Expression" of Non-Coding RNA?

With many non-coding RNAs, the RNA is the functional endpoint. Therefore, ncRNA "expression" simply refers to the production of that functional component. Similarly to with proteins, this involves ...
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3 votes

Small non-coding RNA (sRNA) vs. micro RNA (miRNA)?

Small non-coding RNAs are NOT generally abbreviated as sRNA but as sncRNA, if anything. I say "if anything" because the "small" part is subjective and just a portmanteau descriptor. The straight ...
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2 votes
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Small non-coding RNA (sRNA) vs. micro RNA (miRNA)?

miRNA are one member of the small non-coding RNA family. "Small non-coding" is a pretty broad term that encompasses microRNA and short interfering RNA, among other regulatory RNA species. The key ...
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2 votes

Are non-coding RNAs introns?

Yup - in a lot of cases the transcription of non-coding RNAs is from introns. Some of them are within genes (intragenic) and others are intergenic (between genes). In humans, a large number of both ...
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2 votes
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Where does tracrRNA comes from?

Usually the tracrRNA is a part of the CRISPR locus and is encoded in the the vicinity of the CRISPR array (e.g. upstream or downstream of the cas genes or the array). http://www.genome-engineering....
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2 votes
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Is spliceosomal RNA called snRNP or snRNA?

snRNA: small nuclear ribonucleic acid snRNP: small nuclear ribonucleoprotein snRNA refers to the RNA itself. snRNP refers to snRNA complexed with some protein(s). You could call spliceosomal RNA ...
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2 votes
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How frequent are transposons in action?

To answer your first question and address the title of your post, see this review on active TEs in the human genome. Some excerpts: Although a large proportion (44%) of the human genome is occupied ...
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2 votes
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Difference between LIGR-seq and PARIS methods

LIGR-seq LIGR-seq (Figure 1A) employs in vivo crosslinking of RNA duplexes using the modified psoralen derivative 4′-aminomethyltrioxalen (AMT), which intercalates into RNA duplexes and, upon 365 nm ...
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1 vote
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Where in the cell does this enhancer RNA knockdown take place?

RNAi can happen in the nucleus as well. This is better documented in C.elegans but there are some references supporting nuclear RNAi in mammalian cells too: https://doi.org/10.1073/pnas.1707440114 ...
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1 vote

What is the difference between alarmones and riboswitches

First time I actually hear the word alarmone so bear with me okay? "An Alarmone is an intracellular signal molecule that is produced due to harsh environmental factors. They regulate the gene ...
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1 vote

Which are the best programs to analyze circular RNA?

According to the most recent paper (https://doi.org/10.1093/bib/bbx014), CIRI2 shows a balanced performance on sensitivity and FDR. "Computational detection methods have been widely used in studies ...
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1 vote
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Can ncRNA convert to coding RNA/mRNA by mutations?

Answers Possibly, but with such a low frequency as to be unimportant and undetectable. (Monkeys with typewriters producing Shakespeare’s Hamlet comes to mind.) No. Because it would be extremely ...
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1 vote
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What is meant by "Expression" of Non-Coding RNA?

They queried publications dealing with the lncRNA that studied whether it was functional through over-expression or knockdown. Cells do something measurable in their normal state, that can be observed ...
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