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Prion disease is caused when cellular prion protein (PrPc) is misfolded to form abnormal prion protein called scrapie prion protein (PrPSc). These newly formed abnormal prions can't be degraded by enzymes so they keep on accumulating and are responsible for stimulating other normal proteins to fold improperly and form protein aggregates. Accumulation of ...


Yes, malformed prion proteins can affect tissues outside of the brain. Via: https://www.merckmanuals.com/home/brain,-spinal-cord,-and-nerve-disorders/prion-diseases/overview-of-prion-diseases Another familial prion disease has been recently discovered. It differs from other prion diseases because it causes diarrhea and affects nerves throughout the body ...

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