6
votes
Accepted
How does paracetamol work?
What are the most popular theories in a nutshell?
To date, the mechanism of action of paracetamol is not fully understood. There are some experimental evidences, but it is difficult to put things ...
- 167
5
votes
Accepted
Why do classic psychedelics not cause withdrawal, despite high tolerance?
Short answer
Withdrawal effects are generally associated with drugs that induce feelings of euphoria by stimulating the reward center of the brain, either directly (cocaine, morphine) or indirectly (...
- 52.3k
4
votes
Accepted
Why does the Scatchard plot have a negative gradient?
I think you probably misunderstand which quantities exactly are represented on the Scatchard plot. Let's start from the beginning. Binding between a receptor, $\mathrm R$, and a ligand, $\mathrm L$, ...
- 1,923
4
votes
Accepted
Does ingestion of alcohol with methylphenidate make it act more like dexmethylphenidate?
Does the ingestion of alcohol, when taking (racemic) methylphenidate can actually make it more potent?
It is the 2011 study you've mentioned that answers most of the question.
In the study, ethanol ...
- 8,049
4
votes
Accepted
How to make GABA pass the blood brain barrier?
Short answer
Chemical reversible shielding of the aminogroup in GABA seems to be sufficient to get it into the brain as a Trojan horse.
Background
Given that you ask
...how to make GABA pass ...
- 52.3k
3
votes
Accepted
Why is alcohol such a weak drug?
As Christiaan already pointed out, this depends on the pharmacokinetic and pharmacodynamic parameters. The effective drug concentration depends on the drug-receptor association constant and the drug ...
- 35.2k
3
votes
Estimation of tissue-partition coefficients and clearance for liposomic nanoparticles
Regarding the tissue partition coefficient, Li et al. said: "By using such a parameter, it is assumed that there is the same transfer kinetics of nanoparticles from blood into tissues as from tissues ...
- 326
2
votes
Accepted
Does Povidone-Iodine that penetrates through the skin stays in the body (cells, liver etc)?
Your source (DrugBank via PubChem) is describing the typical pharmacokinetic information (ADME, absorption, distribution, metabolism, excretion) on Providine-Iodine, under the assumption it is not ...
- 8,751
2
votes
Accepted
How could this molecule affect the body? (Lysergic acid derivative)
That is lysergic acid piperidide, an analog of lysergic acid diethylamide (LSD). According to Wikipedia, it is an agonist of the 5-HT2A receptor, but is much less potent than LSD.
- 17.6k
2
votes
Accepted
Cell nanoparticle dynamics within blood
To go the PBPK route:
I would recommend using the organism parameters and structure from the whole body platform model by Shah and Betts.
Shah, D.K. & Betts, A.M. J Pharmacokinet Pharmacodyn (...
- 326
2
votes
Why use a logarithmic scale when plotting pharmacodynamics/kinetics?
There could be several reasons for this. You mention in the comments that your plot of interest is the concentration-time profile. As you can see, plotting the logarithm of concentration vs time ...
- 176
2
votes
What specific interaction between methylphenidate and quetiapine causes toxicity concerns?
quetiapine increases toxicity of methylphenidate by pharmacodynamic antagonism
Pharmacodynamics refers to the study of drug actions, for example the affinity for different receptors is ...
- 44k
1
vote
What specific interaction between methylphenidate and quetiapine causes toxicity concerns?
Think I should first start by mentioning that I am not a physician nor I am trained to make any clinical or diagnostic reasoning. With that in mind, let me try my best to clarify most part of the ...
- 208
1
vote
Accepted
Are there pre-synaptic alpha 2 receptors in the post-ganglionic synapses of the heart?
The heart of course does have Alpha 2 pre synaptic receptors , the definition states that alpha 2 receptors are present on sympathetic postganglionic endings , so I don't see why heart should be an ...
- 152
1
vote
Is an X ml dose of a drug at 50% bioavailability roughly equivalent to a 2X ml dose at 25% bioavailability?
All things being equal, does that mean an administration of a drug will be twice as potent if the bioavailability is doubled?
Bioavailability is initially taught, and sometimes reported as a ...
- 8,751
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