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5 votes
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Why do classic psychedelics not cause withdrawal, despite high tolerance?

Short answer Withdrawal effects are generally associated with drugs that induce feelings of euphoria by stimulating the reward center of the brain, either directly (cocaine, morphine) or indirectly (...
AliceD's user avatar
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4 votes
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Does ingestion of alcohol with methylphenidate make it act more like dexmethylphenidate?

Does the ingestion of alcohol, when taking (racemic) methylphenidate can actually make it more potent? It is the 2011 study you've mentioned that answers most of the question. In the study, ethanol ...
Jan's user avatar
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4 votes
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Why does the Scatchard plot have a negative gradient?

I think you probably misunderstand which quantities exactly are represented on the Scatchard plot. Let's start from the beginning. Binding between a receptor, $\mathrm R$, and a ligand, $\mathrm L$, ...
Domen's user avatar
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4 votes
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How to make GABA pass the blood brain barrier?

Short answer Chemical reversible shielding of the aminogroup in GABA seems to be sufficient to get it into the brain as a Trojan horse. Background Given that you ask ...how to make GABA pass ...
AliceD's user avatar
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3 votes

Estimation of tissue-partition coefficients and clearance for liposomic nanoparticles

Regarding the tissue partition coefficient, Li et al. said: "By using such a parameter, it is assumed that there is the same transfer kinetics of nanoparticles from blood into tissues as from tissues ...
Polymania's user avatar
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2 votes
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How could this molecule affect the body? (Lysergic acid derivative)

That is lysergic acid piperidide, an analog of lysergic acid diethylamide (LSD). According to Wikipedia, it is an agonist of the 5-HT2A receptor, but is much less potent than LSD.
canadianer's user avatar
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2 votes
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Cell nanoparticle dynamics within blood

To go the PBPK route: I would recommend using the organism parameters and structure from the whole body platform model by Shah and Betts. Shah, D.K. & Betts, A.M. J Pharmacokinet Pharmacodyn (...
Polymania's user avatar
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2 votes
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Does Povidone-Iodine that penetrates through the skin stays in the body (cells, liver etc)?

Your source (DrugBank via PubChem) is describing the typical pharmacokinetic information (ADME, absorption, distribution, metabolism, excretion) on Providine-Iodine, under the assumption it is not ...
De Novo's user avatar
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2 votes

Why use a logarithmic scale when plotting pharmacodynamics/kinetics?

There could be several reasons for this. You mention in the comments that your plot of interest is the concentration-time profile. As you can see, plotting the logarithm of concentration vs time ...
mhh's user avatar
  • 176
2 votes

What specific interaction between methylphenidate and quetiapine causes toxicity concerns?

quetiapine increases toxicity of methylphenidate by pharmacodynamic antagonism Pharmacodynamics refers to the study of drug actions, for example the affinity for different receptors is ...
Bryan Krause's user avatar
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1 vote

What specific interaction between methylphenidate and quetiapine causes toxicity concerns?

Think I should first start by mentioning that I am not a physician nor I am trained to make any clinical or diagnostic reasoning. With that in mind, let me try my best to clarify most part of the ...
program's user avatar
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1 vote
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Are there pre-synaptic alpha 2 receptors in the post-ganglionic synapses of the heart?

The heart of course does have Alpha 2 pre synaptic receptors , the definition states that alpha 2 receptors are present on sympathetic postganglionic endings , so I don't see why heart should be an ...
Felix_17's user avatar
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1 vote

Is an X ml dose of a drug at 50% bioavailability roughly equivalent to a 2X ml dose at 25% bioavailability?

All things being equal, does that mean an administration of a drug will be twice as potent if the bioavailability is doubled? Bioavailability is initially taught, and sometimes reported as a ...
De Novo's user avatar
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